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CD4+ T cell effects on CD8+ T cell location defined using bioluminescence.

Azadniv M, Bowers WJ, Topham DJ, Crispe IN.

PLoS One. 2011 Jan 20;6(1):e16222. doi: 10.1371/journal.pone.0016222.


Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions.

Le Saout C, Mennechet S, Taylor N, Hernandez J.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19414-9. doi: 10.1073/pnas.0807743105. Epub 2008 Nov 25.


Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.

Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN.

Nature. 2006 Apr 13;440(7086):890-5.


Deficient contact hypersensitivity reaction in CD4-/- mice is because of impaired hapten-specific CD8+ T cell functions.

Saint-Mezard P, Chavagnac C, Vocanson M, Kehren J, Rozières A, Bosset S, Ionescu M, Dubois B, Kaiserlian D, Nicolas JF, Bérard F.

J Invest Dermatol. 2005 Mar;124(3):562-9.


Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus neoformans infection.

Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB.

J Immunol. 2005 Jun 15;174(12):7920-8.


CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

Janssen EM, Droin NM, Lemmens EE, Pinkoski MJ, Bensinger SJ, Ehst BD, Griffith TS, Green DR, Schoenberger SP.

Nature. 2005 Mar 3;434(7029):88-93.


Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells.

de Goër de Herve MG, Dembele B, Vallée M, Herr F, Cariou A, Taoufik Y.

J Immunol. 2010 Jul 15;185(2):1028-36. doi: 10.4049/jimmunol.0904209. Epub 2010 Jun 18.


Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.

Ryu SJ, Jung KM, Yoo HS, Kim TW, Kim S, Chang J, Choi EY.

Blood. 2009 Apr 30;113(18):4273-80. doi: 10.1182/blood-2008-09-181263. Epub 2009 Jan 12.


Cross-priming of diabetogenic T cells dissociated from CTL-induced shedding of beta cell autoantigens.

Yamanouchi J, Verdaguer J, Han B, Amrani A, Serra P, Santamaria P.

J Immunol. 2003 Dec 15;171(12):6900-9.


CD4+ TH1 cells generated by Ii-PADRE DNA at prime phase are important to induce effectors and memory CD8+ T cells.

Park JY, Jin DH, Lee CM, Jang MJ, Lee SY, Shin HS, Chung YH, Kim KY, Kim SS, Lee WB, Shin YK, Lee WJ, Park YM, Kim D.

J Immunother. 2010 Jun;33(5):510-22. doi: 10.1097/CJI.0b013e3181d75cef.


Divergent roles for CD4+ T cells in the priming and effector/memory phases of adoptive immunotherapy.

Hu HM, Winter H, Urba WJ, Fox BA.

J Immunol. 2000 Oct 15;165(8):4246-53.


CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input.

Kumamoto Y, Mattei LM, Sellers S, Payne GW, Iwasaki A.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8749-54. doi: 10.1073/pnas.1100567108. Epub 2011 May 9.


Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.

Mortarini R, Piris A, Maurichi A, Molla A, Bersani I, Bono A, Bartoli C, Santinami M, Lombardo C, Ravagnani F, Cascinelli N, Parmiani G, Anichini A.

Cancer Res. 2003 May 15;63(10):2535-45.


Failure of CD4 T-cells to respond to liver-derived antigen and to provide help to CD8 T-cells.

Derkow K, Müller A, Eickmeier I, Seidel D, Rust Moreira MV, Kruse N, Klugewitz K, Mintern J, Wiedenmann B, Schott E.

PLoS One. 2011;6(7):e21847. doi: 10.1371/journal.pone.0021847. Epub 2011 Jul 14.


Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.

Jackaman C, Nelson DJ.

Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15.


T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency.

Walton SM, Torti N, Mandaric S, Oxenius A.

Eur J Immunol. 2011 Aug;41(8):2248-59. doi: 10.1002/eji.201141575. Epub 2011 Jul 4.

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