Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 110

Similar articles for PubMed (Select 21224367)


Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.

Li LS, Bey EA, Dong Y, Meng J, Patra B, Yan J, Xie XJ, Brekken RA, Barnett CC, Bornmann WG, Gao J, Boothman DA.

Clin Cancer Res. 2011 Jan 15;17(2):275-85. doi: 10.1158/1078-0432.CCR-10-1983. Epub 2011 Jan 11. Erratum in: Clin Cancer Res. 2011 Mar 1;17(5):1210-1.


An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.

Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA.

Cancer Res. 2012 Jun 15;72(12):3038-47. doi: 10.1158/0008-5472.CAN-11-3135. Epub 2012 Apr 24.


Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.

Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, Buchsbaum DJ, Spitz DR, Gao J, Boothman DA.

Mol Cancer Ther. 2013 Oct;12(10):2110-20. doi: 10.1158/1535-7163.MCT-12-0962. Epub 2013 Jul 24.


An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11832-7. Epub 2007 Jul 3.


Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.

Dong Y, Bey EA, Li LS, Kabbani W, Yan J, Xie XJ, Hsieh JT, Gao J, Boothman DA.

Cancer Res. 2010 Oct 15;70(20):8088-96. doi: 10.1158/0008-5472.CAN-10-1418. Epub 2010 Oct 12.


Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.

Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA.

Cancer Res. 2007 Jul 15;67(14):6936-45.


Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.

Cao L, Li LS, Spruell C, Xiao L, Chakrabarti G, Bey EA, Reinicke KE, Srougi MC, Moore Z, Dong Y, Vo P, Kabbani W, Yang CR, Wang X, Fattah F, Morales JC, Motea EA, Bornmann WG, Yordy JS, Boothman DA.

Antioxid Redox Signal. 2014 Jul 10;21(2):237-50. doi: 10.1089/ars.2013.5462. Epub 2014 Apr 3.


Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.

Park HJ, Choi EK, Choi J, Ahn KJ, Kim EJ, Ji IM, Kook YH, Ahn SD, Williams B, Griffin R, Boothman DA, Lee CK, Song CW.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8866-71.


Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent.

Li JZ, Ke Y, Misra HP, Trush MA, Li YR, Zhu H, Jia Z.

Toxicol Appl Pharmacol. 2014 Dec 15;281(3):285-93. doi: 10.1016/j.taap.2014.10.012. Epub 2014 Oct 29.


Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.

Choi EK, Terai K, Ji IM, Kook YH, Park KH, Oh ET, Griffin RJ, Lim BU, Kim JS, Lee DS, Boothman DA, Loren M, Song CW, Park HJ.

Neoplasia. 2007 Aug;9(8):634-42.


Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.

Reinicke KE, Bey EA, Bentle MS, Pink JJ, Ingalls ST, Hoppel CL, Misico RI, Arzac GM, Burton G, Bornmann WG, Sutton D, Gao J, Boothman DA.

Clin Cancer Res. 2005 Apr 15;11(8):3055-64.


Synergistic enhancement of antitumor effect of β-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1).

Lamberti MJ, Vittar NB, da Silva Fde C, Ferreira VF, Rivarola VA.

Phytomedicine. 2013 Aug 15;20(11):1007-12. doi: 10.1016/j.phymed.2013.04.018. Epub 2013 Jun 7.


Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.

Song CW, Chae JJ, Choi EK, Hwang TS, Kim C, Lim BU, Park HJ.

Int J Hyperthermia. 2008 Mar;24(2):161-9. doi: 10.1080/02656730701781895.


β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.

Park MT, Song MJ, Lee H, Oh ET, Choi BH, Jeong SY, Choi EK, Park HJ.

PLoS One. 2011;6(10):e25976. doi: 10.1371/journal.pone.0025976. Epub 2011 Oct 6.


Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.

Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA, Gao J.

J Control Release. 2007 Oct 8;122(3):365-74. Epub 2007 Apr 29.


Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.

Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Park HJ, Boothman DA, Song CW.

Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):212-9.


beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.

Planchon SM, Pink JJ, Tagliarino C, Bornmann WG, Varnes ME, Boothman DA.

Exp Cell Res. 2001 Jul 1;267(1):95-106.


Sulindac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells.

Kung HN, Weng TY, Liu YL, Lu KS, Chau YP.

PLoS One. 2014 Feb 5;9(2):e88122. doi: 10.1371/journal.pone.0088122. eCollection 2014.


NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone.

Moore Z, Chakrabarti G, Luo X, Ali A, Hu Z, Fattah FJ, Vemireddy R, DeBerardinis RJ, Brekken RA, Boothman DA.

Cell Death Dis. 2015 Jan 15;6:e1599. doi: 10.1038/cddis.2014.564.


β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells.

Park EJ, Min KJ, Lee TJ, Yoo YH, Kim YS, Kwon TK.

Cell Death Dis. 2014 May 15;5:e1230. doi: 10.1038/cddis.2014.202.

Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk