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Results: 1 to 20 of 106

1.

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

Maag D, Maxwell MJ, Hardesty DA, Boucher KL, Choudhari N, Hanno AG, Ma JF, Snowman AS, Pietropaoli JW, Xu R, Storm PB, Saiardi A, Snyder SH, Resnick AC.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1391-6. doi: 10.1073/pnas.1017831108. Epub 2011 Jan 10.

PMID:
21220345
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Blind RD, Suzawa M, Ingraham HA.

Sci Signal. 2012 Jun 19;5(229):ra44. doi: 10.1126/scisignal.2003111.

PMID:
22715467
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inositol polyphosphate multikinase signaling in the regulation of metabolism.

Lee JY, Kim YR, Park J, Kim S.

Ann N Y Acad Sci. 2012 Oct;1271:68-74. doi: 10.1111/j.1749-6632.2012.06725.x. Review.

PMID:
23050966
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

Klippel A, Kavanaugh WM, Pot D, Williams LT.

Mol Cell Biol. 1997 Jan;17(1):338-44.

PMID:
8972214
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A.

J Biol Chem. 2009 Feb 13;284(7):4052-61. doi: 10.1074/jbc.M805032200. Epub 2008 Dec 13.

PMID:
19074768
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.

Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12783-8. Epub 2005 Aug 25.

PMID:
16123124
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inositol pyrophosphates as mammalian cell signals.

Chakraborty A, Kim S, Snyder SH.

Sci Signal. 2011 Aug 23;4(188):re1. doi: 10.1126/scisignal.2001958. Review.

PMID:
21878680
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase.

Didichenko SA, Tilton B, Hemmings BA, Ballmer-Hofer K, Thelen M.

Curr Biol. 1996 Oct 1;6(10):1271-8.

PMID:
8939574
[PubMed - indexed for MEDLINE]
Free Article
9.

Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines.

Razzini G, Berrie CP, Vignati S, Broggini M, Mascetta G, Brancaccio A, Falasca M.

FASEB J. 2000 Jun;14(9):1179-87.

PMID:
10834940
[PubMed - indexed for MEDLINE]
Free Article
10.

Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways.

Gangoiti P, Granado MH, Wang SW, Kong JY, Steinbrecher UP, Gómez-Muñoz A.

Cell Signal. 2008 Apr;20(4):726-36. doi: 10.1016/j.cellsig.2007.12.008. Epub 2007 Dec 17.

PMID:
18234473
[PubMed - indexed for MEDLINE]
11.

Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death.

Xu R, Sen N, Paul BD, Snowman AM, Rao F, Vandiver MS, Xu J, Snyder SH.

Sci Signal. 2013 Apr 2;6(269):ra22. doi: 10.1126/scisignal.2003405. Erratum in: Sci Signal. 2013 Apr 30;6(273):er1.

PMID:
23550211
[PubMed - indexed for MEDLINE]
12.

Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

Mayr GW, Windhorst S, Hillemeier K.

J Biol Chem. 2005 Apr 8;280(14):13229-40. Epub 2005 Jan 19. Erratum in: J Biol Chem. 2007 Nov 30;282(48):35424.

PMID:
15659385
[PubMed - indexed for MEDLINE]
Free Article
13.

EGF stimulates mesangial cell mitogenesis via PI3-kinase-mediated MAPK-dependent and AKT kinase-independent manner: involvement of c-fos and p27Kip1.

Mahimainathan L, Ghosh-Choudhury N, Venkatesan BA, Danda RS, Choudhury GG.

Am J Physiol Renal Physiol. 2005 Jul;289(1):F72-82. Epub 2005 Feb 8.

PMID:
15701816
[PubMed - indexed for MEDLINE]
Free Article
14.

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN.

Cell. 1995 Jun 2;81(5):727-36.

PMID:
7774014
[PubMed - indexed for MEDLINE]
Free Article
15.

Inhibitory effect of antipsychotic drugs on the Con A- and LPS-induced proliferative activity of mouse splenocytes: a possible mechanism of action.

Basta-Kaim A, Budziszewska B, Jagła G, Nowak W, Kubera M, Lasoń W.

J Physiol Pharmacol. 2006 Jun;57(2):247-64.

PMID:
16845229
[PubMed - indexed for MEDLINE]
Free Article
16.

In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.

Meuillet EJ, Ihle N, Baker AF, Gard JM, Stamper C, Williams R, Coon A, Mahadevan D, George BL, Kirkpatrick L, Powis G.

Oncol Res. 2004;14(10):513-27.

PMID:
15559765
[PubMed - indexed for MEDLINE]
17.

The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.

Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9867-72. Epub 2003 Aug 1.

PMID:
12897244
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.

Takai S, Tokuda H, Hanai Y, Kozawa O.

Mol Cell Endocrinol. 2007 Mar 15;267(1-2):46-54. Epub 2006 Dec 16.

PMID:
17215071
[PubMed - indexed for MEDLINE]
20.

Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury.

Hu Z, Sayeed MM.

Am J Physiol Cell Physiol. 2005 May;288(5):C1171-8. Epub 2004 Dec 29.

PMID:
15625305
[PubMed - indexed for MEDLINE]
Free Article

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