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Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42.

Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y, Dieterich W, Zeitz M, Farndale RW, Somasundaram R.

Fibrogenesis Tissue Repair. 2011 Jan 6;4(1):1. doi: 10.1186/1755-1536-4-1.


The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 promotes enzymatic activity of matrixmetalloproteinase-2 in vitro.

Freise C, Ruehl M, Erben U, Farndale RW, Somasundaram R, Heimesaat MM.

Eur J Microbiol Immunol (Bp). 2012 Sep;2(3):186-91. doi: 10.1556/EuJMI.2.2012.3.3. Epub 2012 Sep 10.


The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity.

Freise C, Erben U, Muche M, Farndale R, Zeitz M, Somasundaram R, Ruehl M.

Matrix Biol. 2009 Oct;28(8):480-9. doi: 10.1016/j.matbio.2009.08.001. Epub 2009 Aug 19.


The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 ameliorates acute DSS colitis.

Heimesaat MM, Heilmann K, Kühl AA, Erben U, Rühl M, Fischer A, Farndale RW, Bereswill S, Göbel UB, Zeitz M, Somasundaram R, Freise C.

Eur J Microbiol Immunol (Bp). 2012 Sep;2(3):192-200. doi: 10.1556/EuJMI.2.2012.3.4. Epub 2012 Sep 10.


Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.

Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H.

Eur J Biochem. 1990 Dec 27;194(3):721-30.


Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases.

Nakamura H, Fujii Y, Ohuchi E, Yamamoto E, Okada Y.

Eur J Biochem. 1998 Apr 1;253(1):67-75.


Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells.

Yan L, Moses MA, Huang S, Ingber DE.

J Cell Sci. 2000 Nov;113 ( Pt 22):3979-87.


Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.

Smethurst PA, Onley DJ, Jarvis GE, O'Connor MN, Knight CG, Herr AB, Ouwehand WH, Farndale RW.

J Biol Chem. 2007 Jan 12;282(2):1296-304. Epub 2006 Nov 2.


X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.

Jozic D, Bourenkov G, Lim NH, Visse R, Nagase H, Bode W, Maskos K.

J Biol Chem. 2005 Mar 11;280(10):9578-85. Epub 2004 Dec 15.


Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.

EMBO J. 2001 Sep 3;20(17):4782-93.


MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis.

Kinoh H, Sato H, Tsunezuka Y, Takino T, Kawashima A, Okada Y, Seiki M.

J Cell Sci. 1996 May;109 ( Pt 5):953-9.


Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

Worley JR, Thompkins PB, Lee MH, Hutton M, Soloway P, Edwards DR, Murphy G, Knäuper V.

Biochem J. 2003 Jun 15;372(Pt 3):799-809.


Galardin inhibits collagen degradation by rabbit keratocytes by inhibiting the activation of pro-matrix metalloproteinases.

Hao JL, Nagano T, Nakamura M, Kumagai N, Mishima H, Nishida T.

Exp Eye Res. 1999 May;68(5):565-72.


Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.

Aznavoorian S, Moore BA, Alexander-Lister LD, Hallit SL, Windsor LJ, Engler JA.

Cancer Res. 2001 Aug 15;61(16):6264-75.


Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.

Shamamian P, Schwartz JD, Pocock BJ, Monea S, Whiting D, Marcus SG, Mignatti P.

J Cell Physiol. 2001 Nov;189(2):197-206.

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