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Results: 1 to 20 of 99

1.

The p53 pathway as a target in cancer therapeutics: obstacles and promise.

Mandinova A, Lee SW.

Sci Transl Med. 2011 Jan 5;3(64):64rv1. doi: 10.1126/scitranslmed.3001366. Review.

PMID:
21209413
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Small-molecule inhibitors of MDM2 as new anticancer therapeutics.

Dickens MP, Fitzgerald R, Fischer PM.

Semin Cancer Biol. 2010 Feb;20(1):10-8. doi: 10.1016/j.semcancer.2009.10.003. Epub 2009 Nov 6. Review.

PMID:
19897042
[PubMed - indexed for MEDLINE]
3.

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.

Wiman KG.

Oncogene. 2010 Jul 29;29(30):4245-52. doi: 10.1038/onc.2010.188. Epub 2010 May 24. Review.

PMID:
20498645
[PubMed - indexed for MEDLINE]
4.

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Peltonen K, Colis L, Liu H, Jäämaa S, Moore HM, Enbäck J, Laakkonen P, Vaahtokari A, Jones RJ, af Hällström TM, Laiho M.

PLoS One. 2010 Sep 27;5(9):e12996. doi: 10.1371/journal.pone.0012996.

PMID:
20885994
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

P53: an ubiquitous target of anticancer drugs.

Blagosklonny MV.

Int J Cancer. 2002 Mar 10;98(2):161-6. Review.

PMID:
11857402
[PubMed - indexed for MEDLINE]
6.

Drugging the p53 pathway: understanding the route to clinical efficacy.

Khoo KH, Verma CS, Lane DP.

Nat Rev Drug Discov. 2014 Mar;13(3):217-36. doi: 10.1038/nrd4236. Review. Erratum in: Nat Rev Drug Discov. 2014 Apr;13(4):314. Hoe, Khoo Kian [corrected to Khoo, Kian Hoe].

PMID:
24577402
[PubMed - indexed for MEDLINE]
7.

Current strategies to target p53 in cancer.

Chen F, Wang W, El-Deiry WS.

Biochem Pharmacol. 2010 Sep 1;80(5):724-30. doi: 10.1016/j.bcp.2010.04.031. Epub 2010 May 5. Review.

PMID:
20450892
[PubMed - indexed for MEDLINE]
8.

MDM2 and MDM4: p53 regulators as targets in anticancer therapy.

Toledo F, Wahl GM.

Int J Biochem Cell Biol. 2007;39(7-8):1476-82. Epub 2007 Apr 8. Review.

PMID:
17499002
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Restoration of p53 to limit tumor growth.

Wang W, El-Deiry WS.

Curr Opin Oncol. 2008 Jan;20(1):90-6. Review.

PMID:
18043262
[PubMed - indexed for MEDLINE]
10.

Peptide activators of the p53 tumor suppressor.

Zhan C, Lu W.

Curr Pharm Des. 2011;17(6):603-9. Review.

PMID:
21391910
[PubMed - indexed for MEDLINE]
11.

Awakening guardian angels: drugging the p53 pathway.

Brown CJ, Lain S, Verma CS, Fersht AR, Lane DP.

Nat Rev Cancer. 2009 Dec;9(12):862-73. doi: 10.1038/nrc2763. Review.

PMID:
19935675
[PubMed - indexed for MEDLINE]
12.

Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts.

Wang W, Kim SH, El-Deiry WS.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11003-8. Epub 2006 Jul 11.

PMID:
16835297
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.

Li Q, Lozano G.

Clin Cancer Res. 2013 Jan 1;19(1):34-41. doi: 10.1158/1078-0432.CCR-12-0053. Epub 2012 Dec 21. Review.

PMID:
23262034
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Non-genotoxic p53-activators and their significance as antitumor therapy of future.

Nayak SK, Panesar PS, Kumar H.

Curr Med Chem. 2011;18(7):1038-49. Review.

PMID:
21254973
[PubMed - indexed for MEDLINE]
15.

Mutant p53 rescue and modulation of p53 redox state.

Bykov VJ, Lambert JM, Hainaut P, Wiman KG.

Cell Cycle. 2009 Aug 15;8(16):2509-17. Epub 2009 Aug 29. Review.

PMID:
19633417
[PubMed - indexed for MEDLINE]
Free Article
16.

Targeting the p53 family for cancer therapy: 'big brother' joins the fight.

Bell HS, Ryan KM.

Cell Cycle. 2007 Aug 15;6(16):1995-2000. Epub 2007 Jun 19. Review.

PMID:
17721076
[PubMed - indexed for MEDLINE]
Free Article
17.

The discovery of nongenotoxic activators of p53: building on a cell-based high-throughput screen.

McCarthy AR, Hollick JJ, Westwood NJ.

Semin Cancer Biol. 2010 Feb;20(1):40-5. doi: 10.1016/j.semcancer.2010.02.007. Epub 2010 Mar 4. Review.

PMID:
20206696
[PubMed - indexed for MEDLINE]
18.

Targeting p53 by small molecules in hematological malignancies.

Saha MN, Qiu L, Chang H.

J Hematol Oncol. 2013 Mar 27;6:23. doi: 10.1186/1756-8722-6-23. Review.

PMID:
23531342
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Targeting the p53 pathway.

Golubovskaya VM, Cance WG.

Surg Oncol Clin N Am. 2013 Oct;22(4):747-64. doi: 10.1016/j.soc.2013.06.003. Epub 2013 Jul 30. Review.

PMID:
24012397
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy.

Shangary S, Wang S.

Annu Rev Pharmacol Toxicol. 2009;49:223-41. doi: 10.1146/annurev.pharmtox.48.113006.094723. Review.

PMID:
18834305
[PubMed - indexed for MEDLINE]
Free PMC Article

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