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Results: 1 to 20 of 113

1.

Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions.

Klimentidis YC, Abrams M, Wang J, Fernandez JR, Allison DB.

Hum Genet. 2011 Apr;129(4):407-18. doi: 10.1007/s00439-010-0935-z. Epub 2010 Dec 28.

PMID:
21188420
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Natural selection among Eurasians at genomic regions associated with HIV-1 control.

Klimentidis YC, Aissani B, Shriver MD, Allison DB, Shrestha S.

BMC Evol Biol. 2011 Jun 20;11:173. doi: 10.1186/1471-2148-11-173.

PMID:
21689440
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.

Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V, Pagani L, Prokopenko I, Ritchie GR, Tyler-Smith C, McCarthy MI, Zeggini E, Xue Y.

Am J Hum Genet. 2014 Feb 6;94(2):176-85. doi: 10.1016/j.ajhg.2013.12.010. Epub 2014 Jan 9.

PMID:
24412096
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci.

Cao K, Moormann AM, Lyke KE, Masaberg C, Sumba OP, Doumbo OK, Koech D, Lancaster A, Nelson M, Meyer D, Single R, Hartzman RJ, Plowe CV, Kazura J, Mann DL, Sztein MB, Thomson G, Fernández-Viña MA.

Tissue Antigens. 2004 Apr;63(4):293-325.

PMID:
15009803
[PubMed - indexed for MEDLINE]
5.

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, Nilsen GB, Ruau D, Lincoln SE, Bustamante CD, Butte AJ.

PLoS Genet. 2012;8(4):e1002621. doi: 10.1371/journal.pgen.1002621. Epub 2012 Apr 12.

PMID:
22511877
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.

Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, Morison IM, Mill J, Pidsley R; International Type 2 Diabetes 1q Consortium, Deloukas P, Frayling TM, Hattersley AT, McCarthy MI, Beck S, Hitman GA.

PLoS One. 2010 Nov 18;5(11):e14040. doi: 10.1371/journal.pone.0014040.

PMID:
21124985
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Genetics of type 2 diabetes in East Asian populations.

Cho YS, Lee JY, Park KS, Nho CW.

Curr Diab Rep. 2012 Dec;12(6):686-96. doi: 10.1007/s11892-012-0326-z. Review.

PMID:
22993124
[PubMed - indexed for MEDLINE]
8.

Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.

Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner F, Snyder HJ, Choi M, Hou P, Scolari F, Izzi C, Gigante M, Gesualdo L, Savoldi S, Amoroso A, Cusi D, Zamboli P, Julian BA, Novak J, Wyatt RJ, Mucha K, Perola M, Kristiansson K, Viktorin A, Magnusson PK, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Boland A, Metzger M, Thibaudin L, Wanner C, Jager KJ, Goto S, Maixnerova D, Karnib HH, Nagy J, Panzer U, Xie J, Chen N, Tesar V, Narita I, Berthoux F, Floege J, Stengel B, Zhang H, Lifton RP, Gharavi AG.

PLoS Genet. 2012;8(6):e1002765. doi: 10.1371/journal.pgen.1002765. Epub 2012 Jun 21.

PMID:
22737082
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Natural positive selection and north-south genetic diversity in East Asia.

Suo C, Xu H, Khor CC, Ong RT, Sim X, Chen J, Tay WT, Sim KS, Zeng YX, Zhang X, Liu J, Tai ES, Wong TY, Chia KS, Teo YY.

Eur J Hum Genet. 2012 Jan;20(1):102-10. doi: 10.1038/ejhg.2011.139. Epub 2011 Jul 27.

PMID:
21792231
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.

Li H, Kilpeläinen TO, Liu C, Zhu J, Liu Y, Hu C, Yang Z, Zhang W, Bao W, Cha S, Wu Y, Yang T, Sekine A, Choi BY, Yajnik CS, Zhou D, Takeuchi F, Yamamoto K, Chan JC, Mani KR, Been LF, Imamura M, Nakashima E, Lee N, Fujisawa T, Karasawa S, Wen W, Joglekar CV, Lu W, Chang Y, Xiang Y, Gao Y, Liu S, Song Y, Kwak SH, Shin HD, Park KS, Fall CH, Kim JY, Sham PC, Lam KS, Zheng W, Shu X, Deng H, Ikegami H, Krishnaveni GV, Sanghera DK, Chuang L, Liu L, Hu R, Kim Y, Daimon M, Hotta K, Jia W, Kooner JS, Chambers JC, Chandak GR, Ma RC, Maeda S, Dorajoo R, Yokota M, Takayanagi R, Kato N, Lin X, Loos RJ.

Diabetologia. 2012 Apr;55(4):981-95. doi: 10.1007/s00125-011-2370-7. Epub 2011 Nov 23.

PMID:
22109280
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Similarity in recombination rate and linkage disequilibrium at CYP2C and CYP2D cytochrome P450 gene regions among Europeans indicates signs of selection and no advantage of using tagSNPs in population isolates.

Pimenoff VN, Laval G, Comas D, Palo JU, Gut I, Cann H, Excoffier L, Sajantila A.

Pharmacogenet Genomics. 2012 Dec;22(12):846-57. doi: 10.1097/FPC.0b013e32835a3a6d.

PMID:
23089684
[PubMed - indexed for MEDLINE]
12.

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, Lam VK, Ma RC, So WY, Cho YS, Kim HL, Lee HK, Chan JC, Cho NH.

Diabetes. 2008 Aug;57(8):2226-33. doi: 10.2337/db07-1583. Epub 2008 May 9.

PMID:
18469204
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.

Sabbagh A, Langaney A, Darlu P, Gérard N, Krishnamoorthy R, Poloni ES.

BMC Genet. 2008 Feb 27;9:21. doi: 10.1186/1471-2156-9-21.

PMID:
18304320
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ÅK, Morris AP, McCarthy MI; DIAGRAM Consortium; MuTHER Consortium, Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M.

Nat Genet. 2011 Dec 11;44(1):67-72. doi: 10.1038/ng.1019.

PMID:
22158537
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.

Oleksyk TK, Nelson GW, An P, Kopp JB, Winkler CA.

PLoS One. 2010 Jul 9;5(7):e11474. doi: 10.1371/journal.pone.0011474.

PMID:
20634883
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies.

Song Y, Niu T, Manson JE, Kwiatkowski DJ, Liu S.

Am J Hum Genet. 2004 Feb;74(2):208-22. Epub 2004 Jan 13.

PMID:
14730479
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Southam L, Soranzo N, Montgomery SB, Frayling TM, McCarthy MI, Barroso I, Zeggini E.

Diabetologia. 2009 Sep;52(9):1846-51. doi: 10.1007/s00125-009-1419-3. Epub 2009 Jun 13.

PMID:
19526209
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population.

Robiou-du-Pont S, Bonnefond A, Yengo L, Vaillant E, Lobbens S, Durand E, Weill J, Lantieri O, Balkau B, Charpentier G, Marre M, Froguel P, Meyre D.

Int J Obes (Lond). 2013 Jul;37(7):980-5. doi: 10.1038/ijo.2012.175. Epub 2012 Oct 23.

PMID:
23090577
[PubMed - indexed for MEDLINE]
19.

Genetic variant in fat mass and obesity-associated gene associated with type 2 diabetes risk in Han Chinese.

Qian Y, Liu S, Lu F, Li H, Dong M, Lin Y, Du J, Lin Y, Gong J, Jin G, Dai J, Hu Z, Shen H.

BMC Genet. 2013 Sep 22;14:86. doi: 10.1186/1471-2156-14-86.

PMID:
24053193
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Crohn's disease risk alleles on the NOD2 locus have been maintained by natural selection on standing variation.

Nakagome S, Mano S, Kozlowski L, Bujnicki JM, Shibata H, Fukumaki Y, Kidd JR, Kidd KK, Kawamura S, Oota H.

Mol Biol Evol. 2012 Jun;29(6):1569-85. doi: 10.1093/molbev/mss006. Epub 2012 Jan 12.

PMID:
22319155
[PubMed - indexed for MEDLINE]
Free PMC Article

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