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Items: 1 to 20 of 102

1.

Beta-cell specific expression of suppressor of cytokine signaling-1 (SOCS-1) delays islet allograft rejection by down-regulating Interferon Regulatory Factor-1 (IRF-1) signaling.

Solomon M, Flodström-Tullberg M, Sarvetnick N.

Transpl Immunol. 2011 Apr 15;24(3):181-8. doi: 10.1016/j.trim.2010.11.007. Epub 2010 Dec 1.

PMID:
21130166
2.
3.

Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor.

Chong MM, Thomas HE, Kay TW.

J Biol Chem. 2002 Aug 2;277(31):27945-52. Epub 2002 May 24.

4.

Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.

Gysemans CA, Pavlovic D, Bouillon R, Eizirik DL, Mathieu C.

Diabetologia. 2001 May;44(5):567-74.

PMID:
11380074
5.

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.

Rønn SG, Börjesson A, Bruun C, Heding PE, Frobøse H, Mandrup-Poulsen T, Karlsen AE, Rasschaert J, Sandler S, Billestrup N.

Diabetologia. 2008 Oct;51(10):1873-82. doi: 10.1007/s00125-008-1090-0. Epub 2008 Jul 22.

PMID:
18648765
6.

Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

J Immunol. 2004 May 1;172(9):5714-21.

7.

Interferon regulatory factor-1 is a key transcription factor in murine beta cells under immune attack.

Gysemans C, Callewaert H, Moore F, Nelson-Holte M, Overbergh L, Eizirik DL, Mathieu C.

Diabetologia. 2009 Nov;52(11):2374-84. doi: 10.1007/s00125-009-1514-5. Epub 2009 Sep 8.

PMID:
19756487
8.

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity.

Karlsen AE, Rønn SG, Lindberg K, Johannesen J, Galsgaard ED, Pociot F, Nielsen JH, Mandrup-Poulsen T, Nerup J, Billestrup N.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12191-6. Epub 2001 Oct 2.

9.

The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

Pavlovic D, Chen MC, Gysemans CA, Mathieu C, Eizirik DL.

Eur Cytokine Netw. 1999 Sep;10(3):403-12.

PMID:
10477397
11.
12.

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

Barral AM, Thomas HE, Ling EM, Darwiche R, Rodrigo E, Christen U, Ejrnaes M, Wolfe T, Kay TW, von Herrath MG.

J Autoimmun. 2006 Nov;27(3):166-73. Epub 2006 Oct 10.

PMID:
17045460
13.

Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL.

McKenzie MD, Dudek NL, Mariana L, Chong MM, Trapani JA, Kay TW, Thomas HE.

Int Immunol. 2006 Jun;18(6):837-46. Epub 2006 Mar 30.

14.

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines.

Santangelo C, Scipioni A, Marselli L, Marchetti P, Dotta F.

Eur J Endocrinol. 2005 Mar;152(3):485-9.

15.

No non-redundant function of suppressor of cytokine signaling 2 in insulin producing β-cells.

Puff R, Dames P, Weise M, Göke B, Parhofer K, Lechner A.

Islets. 2010 Jul-Aug;2(4):252-7. doi: 10.4161/isl.2.4.12556.

16.

Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.

Bruun C, Heding PE, Rønn SG, Frobøse H, Rhodes CJ, Mandrup-Poulsen T, Billestrup N.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):32-8. doi: 10.1016/j.mce.2009.07.019. Epub 2009 Jul 28.

PMID:
19643162
17.

Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse.

Flodström-Tullberg M, Yadav D, Hägerkvist R, Tsai D, Secrest P, Stotland A, Sarvetnick N.

Diabetes. 2003 Nov;52(11):2696-700.

18.

β-cell specific overexpression of suppressor of cytokine signalling-3 does not protect against multiple low dose streptozotocin induced type 1 diabetes in mice.

Börjesson A, Rønn SG, Karlsen AE, Billestrup N, Sandler S.

Immunol Lett. 2011 Apr 30;136(1):74-9. doi: 10.1016/j.imlet.2010.12.007. Epub 2011 Jan 13.

PMID:
21237203
19.

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.

20.

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death.

Zaitseva II, Hultcrantz M, Sharoyko V, Flodström-Tullberg M, Zaitsev SV, Berggren PO.

Cell Mol Life Sci. 2009 Dec;66(23):3787-95. doi: 10.1007/s00018-009-0151-y.

PMID:
19763396
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