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Results: 1 to 20 of 113

1.

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

Niesen FH, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney DJ, Pilka ES, Wang M, Oppermann U, Heightman TD, Simeonov A.

PLoS One. 2010 Nov 2;5(11):e13719. doi: 10.1371/journal.pone.0013719.

PMID:
21072165
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents.

Cho H, Tai HH.

Prostaglandins Leukot Essent Fatty Acids. 2002 Dec;67(6):461-5.

PMID:
12468268
[PubMed - indexed for MEDLINE]
3.

Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase.

Cho H, Hamza A, Zhan CG, Tai HH.

Arch Biochem Biophys. 2005 Jan 15;433(2):447-53.

PMID:
15581601
[PubMed - indexed for MEDLINE]
4.

Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Cho H, Tai HH.

Arch Biochem Biophys. 2002 Sep 15;405(2):247-51.

PMID:
12220539
[PubMed - indexed for MEDLINE]
5.

Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.

Cho H, Huang L, Hamza A, Gao D, Zhan CG, Tai HH.

Bioorg Med Chem. 2006 Oct 1;14(19):6486-91. Epub 2006 Jul 7.

PMID:
16828555
[PubMed - indexed for MEDLINE]
6.

Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD).

Jadhav A, Niesen FH, Schultz L, Oppermann U, Maloney DJ, Simeonov A.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Mar 4 [updated 2011 Mar 11].

PMID:
21735612
[PubMed]
Books & Documents
7.

Understanding human 15-hydroxyprostaglandin dehydrogenase binding with NAD+ and PGE2 by homology modeling, docking and molecular dynamics simulation.

Hamza A, Cho H, Tai HH, Zhan CG.

Bioorg Med Chem. 2005 Jul 15;13(14):4544-51.

PMID:
15908215
[PubMed - indexed for MEDLINE]
8.
9.

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

Bullock AN, Russo S, Amos A, Pagano N, Bregman H, Debreczeni JE, Lee WH, von Delft F, Meggers E, Knapp S.

PLoS One. 2009 Oct 20;4(10):e7112. doi: 10.1371/journal.pone.0007112.

PMID:
19841674
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.

Cho H, Oliveira MA, Tai HH.

Arch Biochem Biophys. 2003 Nov 15;419(2):139-46.

PMID:
14592457
[PubMed - indexed for MEDLINE]
11.

Threonine 188 is critical for interaction with NAD+ in human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.

Zhou H, Tai HH.

Biochem Biophys Res Commun. 1999 Apr 13;257(2):414-7.

PMID:
10198228
[PubMed - indexed for MEDLINE]
12.
13.

NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions.

Tai HH, Cho H, Tong M, Ding Y.

Curr Pharm Des. 2006;12(8):955-62. Review.

PMID:
16533162
[PubMed - indexed for MEDLINE]
14.

Structural basis for substrate specificity in human monomeric carbonyl reductases.

Pilka ES, Niesen FH, Lee WH, El-Hawari Y, Dunford JE, Kochan G, Wsol V, Martin HJ, Maser E, Oppermann U.

PLoS One. 2009 Oct 20;4(10):e7113. doi: 10.1371/journal.pone.0007113.

PMID:
19841672
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structural comparison of human mammalian ste20-like kinases.

Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH.

PLoS One. 2010 Aug 6;5(8):e11905. doi: 10.1371/journal.pone.0011905.

PMID:
20730082
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Endogenous inhibitors of human placental prostaglandin dehydrogenase.

Mibe M, Nagai K, Oshige T, Mori N.

Prostaglandins Leukot Essent Fatty Acids. 1992 Jul;46(3):241-5.

PMID:
1508959
[PubMed - indexed for MEDLINE]
17.

Genomic structure and transcriptional regulation of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene.

Nandy A, Jenatschke S, Hartung B, Milde-Langosch K, Bamberger AM, Gellersen B.

J Mol Endocrinol. 2003 Aug;31(1):105-21.

PMID:
12914529
[PubMed - indexed for MEDLINE]
Free Article
18.

15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line.

Quidville V, Segond N, Lausson S, Frenkian M, Cohen R, Jullienne A.

Prostaglandins Other Lipid Mediat. 2006 Oct;81(1-2):14-30. Epub 2006 Sep 1.

PMID:
16997128
[PubMed - indexed for MEDLINE]
19.

Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues.

Ohno H, Morikawa Y, Hirata F.

J Biochem. 1978 Dec;84(6):1485-94.

PMID:
216666
[PubMed - indexed for MEDLINE]
Free Article
20.

15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.

Na HK, Park JM, Lee HG, Lee HN, Myung SJ, Surh YJ.

Biochem Pharmacol. 2011 Nov 15;82(10):1352-60. doi: 10.1016/j.bcp.2011.08.005. Epub 2011 Aug 11.

PMID:
21856294
[PubMed - indexed for MEDLINE]

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