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Items: 1 to 20 of 99

1.

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).

Carriere A, Romeo Y, Acosta-Jaquez HA, Moreau J, Bonneil E, Thibault P, Fingar DC, Roux PP.

J Biol Chem. 2011 Jan 7;286(1):567-77. doi: 10.1074/jbc.M110.159046. Epub 2010 Nov 11.

2.

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP.

Curr Biol. 2008 Sep 9;18(17):1269-77. doi: 10.1016/j.cub.2008.07.078. Epub 2008 Aug 21.

3.

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC.

J Biol Chem. 2010 Jan 1;285(1):80-94. doi: 10.1074/jbc.M109.029637. Epub 2009 Oct 28.

4.

Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.

Wu D, Chapman JR, Wang L, Harris TE, Shabanowitz J, Hunt DF, Fu Z.

J Biol Chem. 2012 Apr 6;287(15):12510-9. doi: 10.1074/jbc.M111.302117. Epub 2012 Feb 22.

5.

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.

Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J.

J Biol Chem. 2007 May 11;282(19):14056-64. Epub 2007 Mar 14.

6.

Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

Shin J, Yang J, Lee JC, Baek KH.

Cell Signal. 2013 Dec;25(12):2540-7. doi: 10.1016/j.cellsig.2013.08.014. Epub 2013 Aug 30.

PMID:
23993963
7.

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

Schalm SS, Fingar DC, Sabatini DM, Blenis J.

Curr Biol. 2003 May 13;13(10):797-806.

8.

Raptor is phosphorylated by cdc2 during mitosis.

Gwinn DM, Asara JM, Shaw RJ.

PLoS One. 2010 Feb 12;5(2):e9197. doi: 10.1371/journal.pone.0009197.

9.

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

Dunlop EA, Dodd KM, Seymour LA, Tee AR.

Cell Signal. 2009 Jul;21(7):1073-84. doi: 10.1016/j.cellsig.2009.02.024. Epub 2009 Mar 9.

PMID:
19272448
10.
11.

Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation.

Kwak D, Choi S, Jeong H, Jang JH, Lee Y, Jeon H, Lee MN, Noh J, Cho K, Yoo JS, Hwang D, Suh PG, Ryu SH.

J Biol Chem. 2012 May 25;287(22):18398-407. doi: 10.1074/jbc.M111.326538. Epub 2012 Apr 4.

12.

The identification of raptor as a substrate for p44/42 MAPK.

Langlais P, Yi Z, Mandarino LJ.

Endocrinology. 2011 Apr;152(4):1264-73. doi: 10.1210/en.2010-1271. Epub 2011 Feb 15.

13.

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.

Vantaggiato C, Formentini I, Bondanza A, Bonini C, Naldini L, Brambilla R.

J Biol. 2006;5(5):14.

14.

Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

Coffman K, Yang B, Lu J, Tetlow AL, Pelliccio E, Lu S, Guo DC, Tang C, Dong MQ, Tamanoi F.

J Biol Chem. 2014 Feb 21;289(8):4723-34. doi: 10.1074/jbc.M113.482067. Epub 2014 Jan 8.

15.
16.

PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence.

Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G.

J Biol Chem. 2004 Nov 5;279(45):46802-9. Epub 2004 Aug 25.

17.

Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction.

Lennartsson J, Blume-Jensen P, Hermanson M, Pontén E, Carlberg M, Rönnstrand L.

Oncogene. 1999 Sep 30;18(40):5546-53.

18.

Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts.

Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T.

J Cell Biochem. 2007 Aug 1;101(5):1266-77.

PMID:
17265428
19.

mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression.

Ekim B, Magnuson B, Acosta-Jaquez HA, Keller JA, Feener EP, Fingar DC.

Mol Cell Biol. 2011 Jul;31(14):2787-801. doi: 10.1128/MCB.05437-11. Epub 2011 May 16.

20.

Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.

Ramírez-Valle F, Badura ML, Braunstein S, Narasimhan M, Schneider RJ.

Mol Cell Biol. 2010 Jul;30(13):3151-64. doi: 10.1128/MCB.00322-09. Epub 2010 May 3.

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