Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 74

1.

Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease.

Eubanks LM, Silhár P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD.

ACS Med Chem Lett. 2010;1(6):268-272.

PMID:
20959871
[PubMed]
Free PMC Article
2.

Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone Pharmacophore.

Burnett JC, Li B, Pai R, Cardinale SC, Butler MM, Peet NP, Moir D, Bavari S, Bowlin T.

Open Access Bioinformatics. 2010 Apr 1;2010(2):11-18.

PMID:
21103387
[PubMed]
Free PMC Article
3.

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Šilhár P, Alakurtti S, Čapková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2229-31. doi: 10.1016/j.bmcl.2011.02.115. Epub 2011 Mar 4.

PMID:
21421315
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.

Li B, Cardinale SC, Butler MM, Pai R, Nuss JE, Peet NP, Bavari S, Bowlin TL.

Bioorg Med Chem. 2011 Dec 15;19(24):7338-48. doi: 10.1016/j.bmc.2011.10.062. Epub 2011 Oct 26.

PMID:
22082667
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S.

Bioorg Med Chem. 2005 Jan 17;13(2):333-41.

PMID:
15598556
[PubMed - indexed for MEDLINE]
6.

Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species.

Atassi MZ, Dolimbek BZ, Hayakari M, Middlebrook JL, Whitney B, Oshima M.

J Protein Chem. 1996 Oct;15(7):691-700.

PMID:
8968960
[PubMed - indexed for MEDLINE]
7.

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD.

Bioorg Med Chem. 2013 Mar 1;21(5):1344-8. doi: 10.1016/j.bmc.2012.12.001. Epub 2012 Dec 20.

PMID:
23340139
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN.

Chem Biol. 2007 May;14(5):533-42.

PMID:
17524984
[PubMed - indexed for MEDLINE]
Free Article
9.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S.

Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93.

PMID:
14511652
[PubMed - indexed for MEDLINE]
10.

Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.

Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT.

Biochemistry. 2007 Sep 18;46(37):10685-93. Epub 2007 Aug 24.

PMID:
17718519
[PubMed - indexed for MEDLINE]
11.

The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication.

Dickerson TJ, Janda KD.

ACS Chem Biol. 2006 Jul 21;1(6):359-69. Review. Erratum in: ACS Chem Biol. 2006 Aug 22;1(7):470.

PMID:
17163773
[PubMed - indexed for MEDLINE]
12.

Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD.

J Comb Chem. 2006 Jul-Aug;8(4):513-21.

PMID:
16827563
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).

Nakai Y, Pellett S, Tepp WH, Johnson EA, Janda KD.

Bioorg Med Chem. 2010 Feb;18(3):1280-7. doi: 10.1016/j.bmc.2009.12.030. Epub 2009 Dec 22. Erratum in: Bioorg Med Chem. 2011 Jul 1;19(13):4154.

PMID:
20044261
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F.

Chen S, Wan HY.

Biochem J. 2011 Jan 15;433(2):277-84. doi: 10.1042/BJ20101310.

PMID:
21029044
[PubMed - indexed for MEDLINE]
Free Article
15.

High level expression of the light chain of botulinum neurotoxin serotype C1 and an efficient HPLC assay to monitor its proteolytic activity.

Rawat R, Ashraf Ahmed S, Swaminathan S.

Protein Expr Purif. 2008 Aug;60(2):165-9. doi: 10.1016/j.pep.2008.03.010. Epub 2008 Mar 25.

PMID:
18482846
[PubMed - indexed for MEDLINE]
16.

Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active.

Ahmed SA, Smith LA.

J Protein Chem. 2000 Aug;19(6):475-87.

PMID:
11195972
[PubMed - indexed for MEDLINE]
17.

Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library.

Miethe S, Rasetti-Escargueil C, Liu Y, Chahboun S, Pelat T, Avril A, Frenzel A, Schirrmann T, Thullier P, Sesardic D, Hust M.

MAbs. 2014 Mar-Apr;6(2):446-59. doi: 10.4161/mabs.27773. Epub 2014 Jan 9.

PMID:
24492304
[PubMed - in process]
Free PMC Article
18.

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.

Nuss JE, Dong Y, Wanner LM, Ruthel G, Wipf P, Gussio R, Vennerstrom JL, Bavari S, Burnett JC.

ACS Med Chem Lett. 2010 Oct 14;1(7):301-305.

PMID:
21116458
[PubMed]
Free PMC Article
19.

Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.

Singh P, Singh MK, Chaudhary D, Chauhan V, Bharadwaj P, Pandey A, Upadhyay N, Dhaked RK.

PLoS One. 2012;7(10):e47110. doi: 10.1371/journal.pone.0047110. Epub 2012 Oct 11. Retraction in: PLoS One. 2013;8(9). doi: 10.1371/annotation/049f74d0-919f-483c-a488-4740ec0a5f4d.

PMID:
23071727
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.

Hu X, Legler PM, Southall N, Maloney DJ, Simeonov A, Jadhav A.

J Comput Aided Mol Des. 2014 Jul;28(7):765-78. doi: 10.1007/s10822-014-9758-7. Epub 2014 Jun 24.

PMID:
24958623
[PubMed - in process]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk