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Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.

Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, Bønaa KH, Spence JD, Nygård O, Jamison R, Gaziano JM, Guarino P, Bennett D, Mir F, Peto R, Collins R; B-Vitamin Treatment Trialists' Collaboration.

Arch Intern Med. 2010 Oct 11;170(18):1622-31. doi: 10.1001/archinternmed.2010.348. Review.


Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial.

Taylor CM, Atkinson C, Penfold C, Bhattacharya S, Campbell D, Davey Smith G, Leary S, Ness A.

J Epidemiol Community Health. 2015 Apr 8. pii: jech-2014-205324. doi: 10.1136/jech-2014-205324. [Epub ahead of print]


[Is folic acid effective for the prevention of cardiovascular events in patients with advanced or terminal chronic kidney disease?].

Peña J, Claro JC.

Rev Med Chil. 2014 May;142(5):636-45. doi: 10.4067/S0034-98872014000500013. Review. Spanish.


The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.

Zeng R, Xu CH, Xu YN, Wang YL, Wang M.

Public Health Nutr. 2015 Jun;18(8):1514-21. doi: 10.1017/S1368980014002134. Epub 2014 Oct 17.


Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals.

Clarke R, Bennett D, Parish S, Lewington S, Skeaff M, Eussen SJ, Lewerin C, Stott DJ, Armitage J, Hankey GJ, Lonn E, Spence JD, Galan P, de Groot LC, Halsey J, Dangour AD, Collins R, Grodstein F; B-Vitamin Treatment Trialists’ Collaboration.

Am J Clin Nutr. 2014 Aug;100(2):657-66. doi: 10.3945/ajcn.113.076349. Epub 2014 Jun 25.


The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: a meta-analysis of randomized controlled trials.

Liu Y, Tian T, Zhang H, Gao L, Zhou X.

Atherosclerosis. 2014 Jul;235(1):31-5. doi: 10.1016/j.atherosclerosis.2014.03.032. Epub 2014 Apr 18.


Effect of B-vitamin supplementation on stroke: a meta-analysis of randomized controlled trials.

Zhang C, Chi FL, Xie TH, Zhou YH.

PLoS One. 2013 Nov 25;8(11):e81577. doi: 10.1371/journal.pone.0081577. eCollection 2013.


Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer: a systematic review and overview of reviews.

Sutcliffe P, Connock M, Gurung T, Freeman K, Johnson S, Kandala NB, Grove A, Gurung B, Morrow S, Clarke A.

Health Technol Assess. 2013 Sep;17(43):1-253. doi: 10.3310/hta17430. Review.


Folic acid supplementation in end-stage renal disease patients reduces total mortality rate.

Chien SC, Li SY, Chen YT, Tsai LW, Chen TJ, Chen TW, Lin YC.

J Nephrol. 2013 Nov-Dec;26(6):1097-104. doi: 10.5301/jn.5000276. Epub 2013 Aug 21.


Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis.

Ji Y, Tan S, Xu Y, Chandra A, Shi C, Song B, Qin J, Gao Y.

Neurology. 2013 Oct 8;81(15):1298-307. doi: 10.1212/WNL.0b013e3182a823cc. Epub 2013 Sep 18.


The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial.

Gommans J, Yi Q, Eikelboom JW, Hankey GJ, Chen C, Rodgers H; VITATOPS trial study group.

BMC Geriatr. 2013 Sep 3;13:88. doi: 10.1186/1471-2318-13-88.


Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.

Andras A, Stansby G, Hansrani M.

Cochrane Database Syst Rev. 2013 Jul 19;7:CD003285. doi: 10.1002/14651858.CD003285.pub2. Review.


Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis.

Hankey GJ, Ford AH, Yi Q, Eikelboom JW, Lees KR, Chen C, Xavier D, Navarro JC, Ranawaka UK, Uddin W, Ricci S, Gommans J, Schmidt R, Almeida OP, van Bockxmeer FM; VITATOPS Trial Study Group.

Stroke. 2013 Aug;44(8):2232-9. doi: 10.1161/STROKEAHA.113.001886. Epub 2013 Jun 13.


Folic acid and vitamin B(12) supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial.

Keser I, Ilich JZ, Vrkić N, Giljević Z, Colić Barić I.

Nutr Res. 2013 Mar;33(3):211-9. doi: 10.1016/j.nutres.2013.01.002. Epub 2013 Feb 1.


The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double-blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke.

Liu X, Shi M, Xia F, Han J, Liu Z, Wang B, Yang F, Li L, Wu S, Wang L, Liu N, Lv Y, Zhao G.

Int J Stroke. 2015 Feb;10(2):264-8. doi: 10.1111/ijs.12017. Epub 2013 Mar 12.


Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals.

Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, Armitage J, Manson JE, Hankey GJ, Spence JD, Galan P, Bønaa KH, Jamison R, Gaziano JM, Guarino P, Baron JA, Logan RF, Giovannucci EL, den Heijer M, Ueland PM, Bennett D, Collins R, Peto R; B-Vitamin Treatment Trialists' Collaboration.

Lancet. 2013 Mar 23;381(9871):1029-36.


Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: a meta-analysis of randomized controlled trials.

Qin X, Huo Y, Xie D, Hou F, Xu X, Wang X.

Clin Nutr. 2013 Oct;32(5):722-7. doi: 10.1016/j.clnu.2012.12.009. Epub 2012 Dec 28.


Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials.

Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL.

Eur J Intern Med. 2012 Dec;23(8):745-54. doi: 10.1016/j.ejim.2012.07.004. Epub 2012 Aug 11.


Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis.

Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong W.

Diabetes Res Clin Pract. 2012 Oct;98(1):151-8. doi: 10.1016/j.diabres.2012.05.027. Epub 2012 Jun 22. Review.


The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis.

Jardine MJ, Kang A, Zoungas S, Navaneethan SD, Ninomiya T, Nigwekar SU, Gallagher MP, Cass A, Strippoli G, Perkovic V.

BMJ. 2012 Jun 13;344:e3533. doi: 10.1136/bmj.e3533. Review.

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