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Results: 1 to 20 of 155

1.

Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.

Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18605-10. doi: 10.1073/pnas.1013309107. Epub 2010 Oct 7.

PMID:
20930120
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling.

Kim S, Foster C, Lecchi A, Quinton TM, Prosser DM, Jin J, Cattaneo M, Kunapuli SP.

Blood. 2002 May 15;99(10):3629-36.

PMID:
11986217
[PubMed - indexed for MEDLINE]
Free Article
3.

Protection against thrombosis in mice lacking PAR3.

Weiss EJ, Hamilton JR, Lease KE, Coughlin SR.

Blood. 2002 Nov 1;100(9):3240-4.

PMID:
12384423
[PubMed - indexed for MEDLINE]
Free Article
4.

Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets.

Arachiche A, de la Fuente M, Nieman MT.

PLoS One. 2013;8(2):e55740. doi: 10.1371/journal.pone.0055740. Epub 2013 Feb 6. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/0956857d-ecf5-4fb7-a834-131915a38a6a.

PMID:
23405206
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Role of thrombin signalling in platelets in haemostasis and thrombosis.

Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR.

Nature. 2001 Sep 6;413(6851):74-8.

PMID:
11544528
[PubMed - indexed for MEDLINE]
6.

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.

Hamilton JR, Cornelissen I, Coughlin SR.

J Thromb Haemost. 2004 Aug;2(8):1429-35.

PMID:
15304051
[PubMed - indexed for MEDLINE]
7.

PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.

Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE.

J Biol Chem. 2006 Sep 8;281(36):26665-74. Epub 2006 Jul 12.

PMID:
16837456
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR.

J Clin Invest. 1999 Mar;103(6):879-87.

PMID:
10079109
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Anticoagulant and antithrombotic properties of intracellular protease-activated receptor antagonists.

Wielders SJ, Bennaghmouch A, Reutelingsperger CP, Bevers EM, Lindhout T.

J Thromb Haemost. 2007 Mar;5(3):571-6. Epub 2006 Dec 13.

PMID:
17166251
[PubMed - indexed for MEDLINE]
10.

A dual thrombin receptor system for platelet activation.

Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR.

Nature. 1998 Aug 13;394(6694):690-4.

PMID:
9716134
[PubMed - indexed for MEDLINE]
11.

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions.

Lee H, Sturgeon SA, Jackson SP, Hamilton JR.

Thromb Haemost. 2012 Feb;107(2):328-37. doi: 10.1160/TH11-06-0418. Epub 2011 Dec 21.

PMID:
22187047
[PubMed - indexed for MEDLINE]
12.

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.

Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN.

J Clin Invest. 2012 Oct 1;122(10):3579-92. doi: 10.1172/JCI38576. Epub 2012 Sep 17.

PMID:
22996695
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Human platelet protease-activated receptor-1 responsiveness to thrombin related to P2Y12 inhibition.

Badr Eslam R, Lang IM, Kaider A, Panzer S.

Transl Res. 2013 May;161(5):414-20. doi: 10.1016/j.trsl.2012.12.009. Epub 2013 Jan 9.

PMID:
23313628
[PubMed - indexed for MEDLINE]
14.

The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine.

Grenegård M, Vretenbrant-Oberg K, Nylander M, Désilets S, Lindström EG, Larsson A, Ramström I, Ramström S, Lindahl TL.

J Biol Chem. 2008 Jul 4;283(27):18493-504. doi: 10.1074/jbc.M800358200. Epub 2008 May 14.

PMID:
18480058
[PubMed - indexed for MEDLINE]
Free Article
15.

Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.

Leger AJ, Jacques SL, Badar J, Kaneider NC, Derian CK, Andrade-Gordon P, Covic L, Kuliopulos A.

Circulation. 2006 Mar 7;113(9):1244-54. Epub 2006 Feb 27.

PMID:
16505172
[PubMed - indexed for MEDLINE]
Free Article
16.

The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.

Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KV.

PLoS One. 2009 Dec 15;4(12):e8304. doi: 10.1371/journal.pone.0008304.

PMID:
20016849
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets.

Covic L, Gresser AL, Kuliopulos A.

Biochemistry. 2000 May 9;39(18):5458-67.

PMID:
10820018
[PubMed - indexed for MEDLINE]
18.

Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.

Chen WF, Lee JJ, Chang CC, Lin KH, Wang SH, Sheu JR.

Haematologica. 2013 May;98(5):793-801. doi: 10.3324/haematol.2012.072553. Epub 2012 Oct 12.

PMID:
23065519
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

PAR3 is a cofactor for PAR4 activation by thrombin.

Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.

Nature. 2000 Apr 6;404(6778):609-13.

PMID:
10766244
[PubMed - indexed for MEDLINE]
20.

P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.

Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, Ding Z.

J Thromb Haemost. 2013 Jan;11(1):149-60. doi: 10.1111/jth.12063.

PMID:
23140172
[PubMed - indexed for MEDLINE]

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