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Items: 1 to 20 of 123

1.

Hedgehog pathway activation in chronic myeloid leukemia.

Jagani Z, Dorsch M, Warmuth M.

Cell Cycle. 2010 Sep 1;9(17):3449-56. Review.

PMID:
20928937
2.

Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells.

Babashah S, Sadeghizadeh M, Hajifathali A, Tavirani MR, Zomorod MS, Ghadiani M, Soleimani M.

Int J Cancer. 2013 Aug 1;133(3):579-89. doi: 10.1002/ijc.28043. Epub 2013 Mar 13.

3.

Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia.

Zeng X, Zhao H, Li Y, Fan J, Sun Y, Wang S, Wang Z, Song P, Ju D.

Autophagy. 2015;11(2):355-72. doi: 10.4161/15548627.2014.994368.

4.

Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells.

Chiarenza A, Manetti F, Petricci E, Ruat M, Naldini A, Taddei M, Carraro F.

PLoS One. 2016 Mar 2;11(3):e0149919. doi: 10.1371/journal.pone.0149919. eCollection 2016.

5.

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Dierks C, Beigi R, Guo GR, Zirlik K, Stegert MR, Manley P, Trussell C, Schmitt-Graeff A, Landwerlin K, Veelken H, Warmuth M.

Cancer Cell. 2008 Sep 9;14(3):238-49. doi: 10.1016/j.ccr.2008.08.003.

6.

Tracking molecular relapse of chronic myeloid leukemia by measuring Hedgehog signaling status.

Cea M, Cagnetta A, Cirmena G, Garuti A, Rocco I, Palermo C, Pierri I, Reverberi D, Nencioni A, Ballestrero A, Gobbi M, Carella AM, Patrone F.

Leuk Lymphoma. 2013 Feb;54(2):342-52. doi: 10.3109/10428194.2012.708752. Epub 2012 Sep 5.

PMID:
22762548
7.
8.

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.

Mar BG, Amakye D, Aifantis I, Buonamici S.

Leukemia. 2011 Nov;25(11):1665-73. doi: 10.1038/leu.2011.143. Epub 2011 Jun 10. Review.

9.

Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer.

Brechbiel J, Miller-Moslin K, Adjei AA.

Cancer Treat Rev. 2014 Jul;40(6):750-9. doi: 10.1016/j.ctrv.2014.02.003. Epub 2014 Feb 24. Review.

PMID:
24613036
10.

Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients.

Long B, Zhu H, Zhu C, Liu T, Meng W.

J Exp Clin Cancer Res. 2011 Jan 16;30:8. doi: 10.1186/1756-9966-30-8.

11.

Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.

Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta-Kishino T, Kagoya Y, Nukina A, Kumagai K, Kubota N, Nakagawa M, Arai S, Yoshimi A, Honda H, Kadowaki T, Kurokawa M.

Oncogene. 2014 Oct 16;33(42):5028-38. doi: 10.1038/onc.2014.108. Epub 2014 Apr 21.

12.

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, Munchhof M, VanArsdale T, Beachy PA, Reya T.

Nature. 2009 Apr 9;458(7239):776-9. doi: 10.1038/nature07737. Erratum in: Nature. 2009 Jul 30;460(7255):652.

13.

Kinase-inhibitor-insensitive cancer stem cells in chronic myeloid leukemia.

Morotti A, Panuzzo C, Fava C, Saglio G.

Expert Opin Biol Ther. 2014 Mar;14(3):287-99. doi: 10.1517/14712598.2014.867323. Epub 2014 Jan 3. Review.

PMID:
24387320
14.

Targeting survival pathways in chronic myeloid leukaemia stem cells.

Sinclair A, Latif AL, Holyoake TL.

Br J Pharmacol. 2013 Aug;169(8):1693-707. doi: 10.1111/bph.12183. Review.

15.

The one-two punch: combination treatment in chronic myeloid leukemia.

Sweet KL, Hazlehurst LA, Pinilla-Ibarz J.

Crit Rev Oncol Hematol. 2013 Dec;88(3):667-79. doi: 10.1016/j.critrevonc.2013.07.017. Epub 2013 Aug 20. Review.

PMID:
23969231
16.

The Alox5 gene is a novel therapeutic target in cancer stem cells of chronic myeloid leukemia.

Chen Y, Li D, Li S.

Cell Cycle. 2009 Nov 1;8(21):3488-92. Epub 2009 Nov 19.

PMID:
19823023
17.

Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells.

Reddiconto G, Toto C, Palamà I, De Leo S, de Luca E, De Matteis S, Dini L, Passerini CG, Di Renzo N, Maffia M, Coluccia AM.

Blood. 2012 Mar 8;119(10):2335-45. doi: 10.1182/blood-2011-06-361261. Epub 2012 Jan 18.

18.

Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells.

Liao HF, Su YC, Zheng ZY, Jhih Cai C, Hou MH, Chao KS, Chen YJ.

Biomed Pharmacother. 2012 Jul;66(5):378-83. doi: 10.1016/j.biopha.2011.12.008. Epub 2012 Feb 16.

PMID:
22397755
19.

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival.

Hamilton A, Helgason GV, Schemionek M, Zhang B, Myssina S, Allan EK, Nicolini FE, Müller-Tidow C, Bhatia R, Brunton VG, Koschmieder S, Holyoake TL.

Blood. 2012 Feb 9;119(6):1501-10. doi: 10.1182/blood-2010-12-326843. Epub 2011 Dec 19.

20.

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.

Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, Li S.

Nat Genet. 2012 Jul 15;44(8):861-71. doi: 10.1038/ng.2350.

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