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Results: 1 to 20 of 92

1.

Alzheimer's secretases regulate voltage-gated sodium channels.

Kovacs DM, Gersbacher MT, Kim DY.

Neurosci Lett. 2010 Dec 10;486(2):68-72. doi: 10.1016/j.neulet.2010.08.048. Epub 2010 Sep 15. Review.

PMID:
20817076
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

BACE1 regulates voltage-gated sodium channels and neuronal activity.

Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM.

Nat Cell Biol. 2007 Jul;9(7):755-64. Epub 2007 Jun 18.

PMID:
17576410
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.

Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY.

FASEB J. 2013 Jun;27(6):2458-67. doi: 10.1096/fj.12-214056. Epub 2013 Mar 15.

PMID:
23504710
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.

Kim DY, Gersbacher MT, Inquimbert P, Kovacs DM.

J Biol Chem. 2011 Mar 11;286(10):8106-16. doi: 10.1074/jbc.M110.134692. Epub 2010 Dec 29.

PMID:
21190943
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.

Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N.

J Biol Chem. 2005 Jun 17;280(24):23009-17. Epub 2005 Apr 11.

PMID:
15824102
[PubMed - indexed for MEDLINE]
Free Article
6.

Voltage-dependent Na+ channels as targets of BACE1 - implications for neuronal firing and beyond.

Huth T, Alzheimer C.

Curr Alzheimer Res. 2012 Feb;9(2):184-8.

PMID:
22455479
[PubMed - indexed for MEDLINE]
7.

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current.

Huth T, Rittger A, Saftig P, Alzheimer C.

Pflugers Arch. 2011 Mar;461(3):355-71. doi: 10.1007/s00424-010-0913-2. Epub 2011 Jan 19.

PMID:
21246381
[PubMed - indexed for MEDLINE]
8.

The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein.

Tabaton M, Tamagno E.

Cell Mol Life Sci. 2007 Sep;64(17):2211-8. Review.

PMID:
17604999
[PubMed - indexed for MEDLINE]
9.

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.

Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM.

J Biol Chem. 2005 Jun 17;280(24):23251-61. Epub 2005 Apr 14. Erratum in: J Biol Chem. 2005 Aug 19;280(33):29988.

PMID:
15833746
[PubMed - indexed for MEDLINE]
Free Article
10.

BACE1 structure and function in health and Alzheimer's disease.

Cole SL, Vassar R.

Curr Alzheimer Res. 2008 Apr;5(2):100-20. Review.

PMID:
18393796
[PubMed - indexed for MEDLINE]
11.

Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.

Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, Pangalos MN, Reinhart PH, Chin J.

J Neurosci. 2013 Apr 17;33(16):7020-6. doi: 10.1523/JNEUROSCI.2325-12.2013. Erratum in: J Neurosci. 2013 Jun 26;33(26):10934. Brown, Jon T [added]; Randall, Andrew D [added].

PMID:
23595759
[PubMed - indexed for MEDLINE]
Free Article
12.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

PMID:
18263584
[PubMed - indexed for MEDLINE]
Free Article
13.

Natural compounds that modulate BACE1-processing of amyloid-beta precursor protein in Alzheimer's disease.

Zhang C.

Discov Med. 2012 Sep;14(76):189-97. Review.

PMID:
23021373
[PubMed - indexed for MEDLINE]
Free Article
14.

BACE1: the beta-secretase enzyme in Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2004;23(1-2):105-14. Review.

PMID:
15126696
[PubMed - indexed for MEDLINE]
15.

Identification and biology of β-secretase.

Kandalepas PC, Vassar R.

J Neurochem. 2012 Jan;120 Suppl 1:55-61. doi: 10.1111/j.1471-4159.2011.07512.x. Epub 2011 Nov 28. Review.

PMID:
22122287
[PubMed - indexed for MEDLINE]
16.

SUMO1 modulates Aβ generation via BACE1 accumulation.

Yun SM, Cho SJ, Song JC, Song SY, Jo SA, Jo C, Yoon K, Tanzi RE, Choi EJ, Koh YH.

Neurobiol Aging. 2013 Mar;34(3):650-62. doi: 10.1016/j.neurobiolaging.2012.08.005. Epub 2012 Sep 11.

PMID:
22975420
[PubMed - indexed for MEDLINE]
17.

The beta-secretase, BACE: a prime drug target for Alzheimer's disease.

Vassar R.

J Mol Neurosci. 2001 Oct;17(2):157-70. Review.

PMID:
11816789
[PubMed - indexed for MEDLINE]
18.

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.

PMID:
17409228
[PubMed - indexed for MEDLINE]
Free Article
19.

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.

J Neurochem. 2009 Jul;110(1):275-83. doi: 10.1111/j.1471-4159.2009.06131.x. Epub 2009 Apr 29.

PMID:
19457123
[PubMed - indexed for MEDLINE]
20.

The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.

Verdile G, Gandy SE, Martins RN.

Neurochem Res. 2007 Apr-May;32(4-5):609-23. Epub 2006 Aug 31. Review.

PMID:
16944319
[PubMed - indexed for MEDLINE]
Free PMC Article

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