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Items: 1 to 20 of 103

1.

The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.

Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ.

J Biol Chem. 2010 Oct 22;285(43):32897-905. doi: 10.1074/jbc.M110.146373. Epub 2010 Aug 20.

2.

HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.

Durkin SS, Guo X, Fryrear KA, Mihaylova VT, Gupta SK, Belgnaoui SM, Haoudi A, Kupfer GM, Semmes OJ.

J Biol Chem. 2008 Dec 26;283(52):36311-20. doi: 10.1074/jbc.M804931200. Epub 2008 Oct 27.

3.

MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.

PMID:
12607005
4.

Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.

Gupta SK, Guo X, Durkin SS, Fryrear KF, Ward MD, Semmes OJ.

J Biol Chem. 2007 Oct 5;282(40):29431-40. Epub 2007 Aug 13.

5.

Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response.

Chandhasin C, Ducu RI, Berkovich E, Kastan MB, Marriott SJ.

J Virol. 2008 Jul;82(14):6952-61. doi: 10.1128/JVI.02331-07. Epub 2008 Apr 23.

6.

MDC1 interacts with Rad51 and facilitates homologous recombination.

Zhang J, Ma Z, Treszezamsky A, Powell SN.

Nat Struct Mol Biol. 2005 Oct;12(10):902-9. Epub 2005 Sep 25.

PMID:
16186822
7.

Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation.

Shi W, Ma Z, Willers H, Akhtar K, Scott SP, Zhang J, Powell S, Zhang J.

J Biol Chem. 2008 Nov 14;283(46):31608-16. doi: 10.1074/jbc.M801082200. Epub 2008 Aug 29.

8.

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J.

EMBO J. 2004 Jul 7;23(13):2674-83. Epub 2004 Jun 17.

10.

MDC1 is required for the intra-S-phase DNA damage checkpoint.

Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP.

Nature. 2003 Feb 27;421(6926):952-6.

PMID:
12607003
11.

Three-dimensional imaging reveals the spatial separation of γH2AX-MDC1-53BP1 and RNF8-RNF168-BRCA1-A complexes at ionizing radiation-induced foci.

Mok MT, Henderson BR.

Radiother Oncol. 2012 Jun;103(3):415-20. doi: 10.1016/j.radonc.2012.04.009. Epub 2012 May 24.

PMID:
22633816
12.

The in vivo dynamic interplay of MDC1 and 53BP1 at DNA damage-induced nuclear foci.

Mok MT, Henderson BR.

Int J Biochem Cell Biol. 2012 Sep;44(9):1398-409. doi: 10.1016/j.biocel.2012.05.025. Epub 2012 Jun 5.

PMID:
22677490
13.

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

Chapman JR, Jackson SP.

EMBO Rep. 2008 Aug;9(8):795-801. doi: 10.1038/embor.2008.103. Epub 2008 Jun 27.

14.

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM.

Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95.

15.
16.

The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.

Au WW, Henderson BR.

J Biol Chem. 2005 Feb 25;280(8):6993-7001. Epub 2004 Nov 29.

17.

Assembly and function of DNA double-strand break repair foci in mammalian cells.

Bekker-Jensen S, Mailand N.

DNA Repair (Amst). 2010 Dec 10;9(12):1219-28. doi: 10.1016/j.dnarep.2010.09.010. Epub 2010 Oct 28. Review.

PMID:
21035408
18.
19.

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W.

J Cell Biol. 2009 Sep 21;186(6):835-47. doi: 10.1083/jcb.200902150.

20.
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