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Items: 1 to 20 of 119


Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H.

J Clin Invest. 2010 Sep;120(9):3167-78. doi: 10.1172/JCI42629. Epub 2010 Aug 16.


Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

Kerschen EJ, Fernandez JA, Cooley BC, Yang XV, Sood R, Mosnier LO, Castellino FJ, Mackman N, Griffin JH, Weiler H.

J Exp Med. 2007 Oct 1;204(10):2439-48. Epub 2007 Sep 24.


The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.

Cao C, Gao Y, Li Y, Antalis TM, Castellino FJ, Zhang L.

J Clin Invest. 2010 Jun;120(6):1971-80. doi: 10.1172/JCI40380. Epub 2010 May 10.


Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

Schuepbach RA, Feistritzer C, Fernández JA, Griffin JH, Riewald M.

Thromb Haemost. 2009 Apr;101(4):724-33.


Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia.

Zheng X, Li W, Song Y, Hu Y, Ferrell GL, Esmon NL, Esmon CT.

J Thromb Haemost. 2007 Jul;5(7):1394-400. Epub 2007 Apr 18.


Activated protein C signals through the thrombin receptor PAR1 in endothelial cells.

Riewald M, Petrovan RJ, Donner A, Ruf W.

J Endotoxin Res. 2003;9(5):317-21.


Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W.

Blood. 2009 Mar 19;113(12):2859-66. doi: 10.1182/blood-2008-12-192385. Epub 2009 Jan 13. Retraction in: Blood. 2011 Jun 30;117(26):7188.


Activated protein C induces the release of microparticle-associated endothelial protein C receptor.

Pérez-Casal M, Downey C, Fukudome K, Marx G, Toh CH.

Blood. 2005 Feb 15;105(4):1515-22. Epub 2004 Oct 14.


New players in the sepsis-protective activated protein C pathway.

Ruf W.

J Clin Invest. 2010 Sep;120(9):3084-7. doi: 10.1172/JCI44266. Epub 2010 Aug 16.


The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.

Kager LM, Roelofs JJ, de Vos AF, Wieland CW, Schouten M, Meijers JC, Isermann B, Van't Veer C, Esmon CT, van der Poll T.

Thromb Haemost. 2013 Apr;109(4):726-37. doi: 10.1160/TH12-11-0859. Epub 2013 Jan 24.


Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-κB, and ERK1/2 MAP kinases.

Guitton C, Cottereau A, Gérard N, Quillard T, Chauveau A, Devallière J, Tonnerre P, Charreau B.

Am J Physiol Cell Physiol. 2011 Apr;300(4):C833-42. doi: 10.1152/ajpcell.00003.2010. Epub 2011 Jan 12.


Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.

Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV.

J Cereb Blood Flow Metab. 2009 Jan;29(1):25-33. doi: 10.1038/jcbfm.2008.117. Epub 2008 Oct 8.


Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.

Uchiba M, Okajima K, Oike Y, Ito Y, Fukudome K, Isobe H, Suda T.

Circ Res. 2004 Jul 9;95(1):34-41. Epub 2004 May 27.


PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2015 Nov;21(11):1307-17. doi: 10.1038/nm.3960. Epub 2015 Oct 12.


Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells.

Bae JS, Yang L, Rezaie AR.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2867-72. Epub 2007 Feb 13.


Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV.

Blood. 2003 Jun 15;101(12):4797-801. Epub 2003 Feb 13.


Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.

Bouwens EA, Stavenuiter F, Mosnier LO.

J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247. Review.


Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.

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