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Results: 1 to 20 of 323

1.

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome.

Gross C, Nakamoto M, Yao X, Chan CB, Yim SY, Ye K, Warren ST, Bassell GJ.

J Neurosci. 2010 Aug 11;30(32):10624-38. doi: 10.1523/JNEUROSCI.0402-10.2010.

PMID:
20702695
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Dysregulation of mTOR signaling in fragile X syndrome.

Sharma A, Hoeffer CA, Takayasu Y, Miyawaki T, McBride SM, Klann E, Zukin RS.

J Neurosci. 2010 Jan 13;30(2):694-702. doi: 10.1523/JNEUROSCI.3696-09.2010.

PMID:
20071534
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome.

Muddashetty RS, Kelić S, Gross C, Xu M, Bassell GJ.

J Neurosci. 2007 May 16;27(20):5338-48.

PMID:
17507556
[PubMed - indexed for MEDLINE]
Free Article
4.

Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression.

Niere F, Wilkerson JR, Huber KM.

J Neurosci. 2012 Apr 25;32(17):5924-36. doi: 10.1523/JNEUROSCI.4650-11.2012.

PMID:
22539853
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110β-selective inhibitor.

Gross C, Bassell GJ.

Mol Med. 2012 May 9;18:336-45. doi: 10.2119/molmed.2011.00363.

PMID:
22207187
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.

Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15537-42. Epub 2007 Sep 19.

PMID:
17881561
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis.

Auerbach BD, Bear MF.

J Neurophysiol. 2010 Aug;104(2):1047-51. doi: 10.1152/jn.00449.2010. Epub 2010 Jun 16.

PMID:
20554840
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

Nosyreva ED, Huber KM.

J Neurophysiol. 2006 May;95(5):3291-5. Epub 2006 Feb 1.

PMID:
16452252
[PubMed - indexed for MEDLINE]
Free Article
9.

c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins.

Schmit TL, Dowell JA, Maes ME, Wilhelm M.

J Neurochem. 2013 Dec;127(6):772-81. doi: 10.1111/jnc.12453. Epub 2013 Oct 24.

PMID:
24047560
[PubMed - indexed for MEDLINE]
10.

Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.

Zhang L, Alger BE.

J Neurosci. 2010 Apr 21;30(16):5724-9. doi: 10.1523/JNEUROSCI.0795-10.2010.

PMID:
20410124
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice.

Iliff AJ, Renoux AJ, Krans A, Usdin K, Sutton MA, Todd PK.

Hum Mol Genet. 2013 Mar 15;22(6):1180-92. doi: 10.1093/hmg/dds525. Epub 2012 Dec 18.

PMID:
23250915
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses.

Antar LN, Afroz R, Dictenberg JB, Carroll RC, Bassell GJ.

J Neurosci. 2004 Mar 17;24(11):2648-55.

PMID:
15028757
[PubMed - indexed for MEDLINE]
Free Article
13.

Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation.

Nalavadi VC, Muddashetty RS, Gross C, Bassell GJ.

J Neurosci. 2012 Feb 22;32(8):2582-7. doi: 10.1523/JNEUROSCI.5057-11.2012.

PMID:
22357842
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.

PMID:
22993295
[PubMed - indexed for MEDLINE]
Free Article
15.

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome.

Liu ZH, Huang T, Smith CB.

Neurobiol Dis. 2012 Mar;45(3):1145-52. doi: 10.1016/j.nbd.2011.12.037. Epub 2011 Dec 29.

PMID:
22227453
[PubMed - indexed for MEDLINE]
16.

Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.

Gross C, Yao X, Pong DL, Jeromin A, Bassell GJ.

J Neurosci. 2011 Apr 13;31(15):5693-8. doi: 10.1523/JNEUROSCI.6661-10.2011.

PMID:
21490210
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade.

Narayanan U, Nalavadi V, Nakamoto M, Thomas G, Ceman S, Bassell GJ, Warren ST.

J Biol Chem. 2008 Jul 4;283(27):18478-82. doi: 10.1074/jbc.C800055200. Epub 2008 May 12.

PMID:
18474609
[PubMed - indexed for MEDLINE]
Free PMC Article
18.
19.

Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.

Osterweil EK, Krueger DD, Reinhold K, Bear MF.

J Neurosci. 2010 Nov 17;30(46):15616-27. doi: 10.1523/JNEUROSCI.3888-10.2010.

PMID:
21084617
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.

Ronesi JA, Huber KM.

Sci Signal. 2008 Feb 5;1(5):pe6. doi: 10.1126/stke.15pe6. Review.

PMID:
18272470
[PubMed - indexed for MEDLINE]

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