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Items: 1 to 20 of 123

1.

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.

Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, Mootha VK.

Nature. 2010 Sep 16;467(7313):291-6. doi: 10.1038/nature09358. Epub 2010 Aug 8.

2.

Cell biology: A sensor for calcium uptake.

Collins S, Meyer T.

Nature. 2010 Sep 16;467(7313):283. doi: 10.1038/467283a. No abstract available.

3.

SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M.

Mol Biol Cell. 2014 Mar;25(6):936-47. doi: 10.1091/mbc.E13-08-0502. Epub 2014 Jan 15.

4.

Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.

Waldeck-Weiermair M, Jean-Quartier C, Rost R, Khan MJ, Vishnu N, Bondarenko AI, Imamura H, Malli R, Graier WF.

J Biol Chem. 2011 Aug 12;286(32):28444-55. doi: 10.1074/jbc.M111.244517. Epub 2011 May 25.

5.

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.

Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK.

PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

6.

MICU1 motifs define mitochondrial calcium uniporter binding and activity.

Hoffman NE, Chandramoorthy HC, Shamugapriya S, Zhang X, Rajan S, Mallilankaraman K, Gandhirajan RK, Vagnozzi RJ, Ferrer LM, Sreekrishnanilayam K, Natarajaseenivasan K, Vallem S, Force T, Choi ET, Cheung JY, Madesh M.

Cell Rep. 2013 Dec 26;5(6):1576-88. doi: 10.1016/j.celrep.2013.11.026. Epub 2013 Dec 12.

7.

Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells.

Alam MR, Groschner LN, Parichatikanond W, Kuo L, Bondarenko AI, Rost R, Waldeck-Weiermair M, Malli R, Graier WF.

J Biol Chem. 2012 Oct 5;287(41):34445-54. doi: 10.1074/jbc.M112.392084. Epub 2012 Aug 17.

8.

EMRE is an essential component of the mitochondrial calcium uniporter complex.

Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.

Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.

9.

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Mallilankaraman K, Cárdenas C, Doonan PJ, Chandramoorthy HC, Irrinki KM, Golenár T, Csordás G, Madireddi P, Yang J, Müller M, Miller R, Kolesar JE, Molgó J, Kaufman B, Hajnóczky G, Foskett JK, Madesh M.

Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25. Erratum in: Nat Cell Biol. 2015 Jul;17(7):953. Nat Cell Biol. 2013 Jan;15(1):123.

10.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.

11.

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, de la Fuente Perez S, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G.

Cell Metab. 2013 Jun 4;17(6):976-87. doi: 10.1016/j.cmet.2013.04.020.

12.

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake.

Wang L, Yang X, Li S, Wang Z, Liu Y, Feng J, Zhu Y, Shen Y.

EMBO J. 2014 Mar 18;33(6):594-604. doi: 10.1002/embj.201386523. Epub 2014 Feb 10.

13.

Dynamics of mitochondrial Ca2+ uptake in MICU1-knockdown cells.

de la Fuente S, Matesanz-Isabel J, Fonteriz RI, Montero M, Alvarez J.

Biochem J. 2014 Feb 15;458(1):33-40. doi: 10.1042/BJ20131025.

PMID:
24313810
14.

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.

Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK.

Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234.

15.

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.

Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E.

Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.

PMID:
24336167
16.

MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.

Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, Granatiero V, Szabò I, De Stefani D, Rizzuto R.

Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20.

17.

Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA).

Waldeck-Weiermair M, Deak AT, Groschner LN, Alam MR, Jean-Quartier C, Malli R, Graier WF.

J Biol Chem. 2013 May 24;288(21):15367-79. doi: 10.1074/jbc.M113.462259. Epub 2013 Apr 16.

18.

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter.

Kamer KJ, Mootha VK.

EMBO Rep. 2014 Mar;15(3):299-307. doi: 10.1002/embr.201337946. Epub 2014 Feb 6.

19.

NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.

De Marchi U, Santo-Domingo J, Castelbou C, Sekler I, Wiederkehr A, Demaurex N.

J Biol Chem. 2014 Jul 18;289(29):20377-85. doi: 10.1074/jbc.M113.540898. Epub 2014 Jun 4.

20.

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME.

PLoS One. 2014 May 6;9(5):e96866. doi: 10.1371/journal.pone.0096866. eCollection 2014.

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