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Results: 1 to 20 of 217

1.

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.

Canals D, Jenkins RW, Roddy P, Hernández-Corbacho MJ, Obeid LM, Hannun YA.

J Biol Chem. 2010 Oct 15;285(42):32476-85. doi: 10.1074/jbc.M110.141028. Epub 2010 Aug 2.

PMID:
20679347
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.

Canals D, Roddy P, Hannun YA.

J Biol Chem. 2012 Mar 23;287(13):10145-55. doi: 10.1074/jbc.M111.306456. Epub 2012 Feb 6.

PMID:
22311981
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.

Tani M, Igarashi Y, Ito M.

J Biol Chem. 2005 Nov 4;280(44):36592-600. Epub 2005 Aug 25.

PMID:
16126722
[PubMed - indexed for MEDLINE]
Free Article
4.

Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space.

Tani M, Ito M, Igarashi Y.

Cell Signal. 2007 Feb;19(2):229-37. Epub 2006 Sep 11. Review.

PMID:
16963225
[PubMed - indexed for MEDLINE]
5.

Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.

Orr Gandy KA, Adada M, Canals D, Carroll B, Roddy P, Hannun YA, Obeid LM.

FASEB J. 2013 Aug;27(8):3155-66. doi: 10.1096/fj.13-228460. Epub 2013 Apr 29.

PMID:
23629860
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

Kono M, Dreier JL, Ellis JM, Allende ML, Kalkofen DN, Sanders KM, Bielawski J, Bielawska A, Hannun YA, Proia RL.

J Biol Chem. 2006 Mar 17;281(11):7324-31. Epub 2005 Dec 27.

PMID:
16380386
[PubMed - indexed for MEDLINE]
Free Article
7.

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.

Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA, Brenner DA.

J Biol Chem. 2005 Jul 29;280(30):27879-87. Epub 2005 Jun 9.

PMID:
15946935
[PubMed - indexed for MEDLINE]
Free Article
8.

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.

Gangoiti P, Camacho L, Arana L, Ouro A, Granado MH, Brizuela L, Casas J, Fabriás G, Abad JL, Delgado A, Gómez-Muñoz A.

Prog Lipid Res. 2010 Oct;49(4):316-34. doi: 10.1016/j.plipres.2010.02.004. Epub 2010 Mar 1. Review.

PMID:
20193711
[PubMed - indexed for MEDLINE]
9.

Sphingolipids in mammalian cell signalling.

Ohanian J, Ohanian V.

Cell Mol Life Sci. 2001 Dec;58(14):2053-68. Review.

PMID:
11814056
[PubMed - indexed for MEDLINE]
10.

Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.

Adada M, Canals D, Hannun YA, Obeid LM.

Biochim Biophys Acta. 2014 May;1841(5):727-37. doi: 10.1016/j.bbalip.2013.07.002. Epub 2013 Jul 12. Review.

PMID:
23850862
[PubMed - indexed for MEDLINE]
11.

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.

Tani M, Sano T, Ito M, Igarashi Y.

J Lipid Res. 2005 Nov;46(11):2458-67. Epub 2005 Aug 1.

PMID:
16061940
[PubMed - indexed for MEDLINE]
Free Article
12.

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate.

Kihara A, Mitsutake S, Mizutani Y, Igarashi Y.

Prog Lipid Res. 2007 Mar;46(2):126-44. Epub 2007 Mar 14. Review.

PMID:
17449104
[PubMed - indexed for MEDLINE]
13.

Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.

Taniguchi M, Kitatani K, Kondo T, Hashimoto-Nishimura M, Asano S, Hayashi A, Mitsutake S, Igarashi Y, Umehara H, Takeya H, Kigawa J, Okazaki T.

J Biol Chem. 2012 Nov 16;287(47):39898-910. doi: 10.1074/jbc.M112.416552. Epub 2012 Oct 3.

PMID:
23035115
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging.

Lightle SA, Oakley JI, Nikolova-Karakashian MN.

Mech Ageing Dev. 2000 Dec 1;120(1-3):111-25.

PMID:
11087909
[PubMed - indexed for MEDLINE]
15.
16.

Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.

Gandy KA, Canals D, Adada M, Wada M, Roddy P, Snider AJ, Hannun YA, Obeid LM.

Biochem J. 2013 Feb 1;449(3):661-72. doi: 10.1042/BJ20120213.

PMID:
23106337
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.

Huwiler A, Pfeilschifter J.

Curr Pharm Des. 2006;12(35):4625-35.

PMID:
17168766
[PubMed - indexed for MEDLINE]
18.

Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol.

De Luca T, Bosneaga E, Morré DM, Morré DJ.

Biofactors. 2008;34(3):253-60. doi: 10.3233/BIO-2009-1079.

PMID:
19734127
[PubMed - indexed for MEDLINE]
19.

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.

Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B.

Future Oncol. 2010 Oct;6(10):1603-24. doi: 10.2217/fon.10.116. Review.

PMID:
21062159
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.

Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH Jr, Futerman AH.

J Biol Chem. 2008 Feb 29;283(9):5677-84. doi: 10.1074/jbc.M707386200. Epub 2007 Dec 28.

PMID:
18165233
[PubMed - indexed for MEDLINE]
Free Article

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