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Results: 1 to 20 of 103

1.

Increased abundance of opioid receptor heteromers after chronic morphine administration.

Gupta A, Mulder J, Gomes I, Rozenfeld R, Bushlin I, Ong E, Lim M, Maillet E, Junek M, Cahill CM, Harkany T, Devi LA.

Sci Signal. 2010 Jul 20;3(131):ra54. doi: 10.1126/scisignal.2000807.

PMID:
20647592
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Functional relevance of μ-δ opioid receptor heteromerization: a role in novel signaling and implications for the treatment of addiction disorders: from a symposium on new concepts in mu-opioid pharmacology.

Stockton SD Jr, Devi LA.

Drug Alcohol Depend. 2012 Mar 1;121(3):167-72. doi: 10.1016/j.drugalcdep.2011.10.025. Epub 2011 Nov 23. Review.

PMID:
22115888
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

μ-δ opioid receptor heteromer-specific signaling in the striatum and hippocampus.

Kabli N, Fan T, O'Dowd BF, George SR.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):906-11. doi: 10.1016/j.bbrc.2014.06.099. Epub 2014 Jun 26.

PMID:
24976397
[PubMed - indexed for MEDLINE]
4.

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.

Gomes I, Fujita W, Gupta A, Saldanha SA, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12072-7. doi: 10.1073/pnas.1222044110. Epub 2013 Jul 1. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):1760. Saldanha, Adrian S [corrected to Saldanha, S Adrian]; Eberhart, Christina [added].

PMID:
23818586
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.

Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL.

PLoS One. 2013;8(3):e58362. doi: 10.1371/journal.pone.0058362. Epub 2013 Mar 15.

PMID:
23554887
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.

García-Sevilla JA, Ferrer-Alcón M, Martín M, Kieffer BL, Maldonado R.

Neuropharmacology. 2004 Mar;46(4):519-30.

PMID:
14975676
[PubMed - indexed for MEDLINE]
7.

Agonists at the δ-opioid receptor modify the binding of µ-receptor agonists to the µ-δ receptor hetero-oligomer.

Kabli N, Martin N, Fan T, Nguyen T, Hasbi A, Balboni G, O'Dowd BF, George SR.

Br J Pharmacol. 2010 Nov;161(5):1122-36. doi: 10.1111/j.1476-5381.2010.00944.x.

PMID:
20977461
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.

Xu H, Wang X, Partilla JS, Bishop-Mathis K, Benaderet TS, Dersch CM, Simpson DS, Prisinzano TE, Rothman RB.

Brain Res Bull. 2008 Sep 5;77(1):49-54. doi: 10.1016/j.brainresbull.2008.05.003. Epub 2008 Jun 4.

PMID:
18639745
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS.

ACS Chem Neurosci. 2012 Jul 18;3(7):505-9. doi: 10.1021/cn3000394. Epub 2012 May 22.

PMID:
22860219
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward.

David V, Matifas A, Gavello-Baudy S, Decorte L, Kieffer BL, Cazala P.

Neuropsychopharmacology. 2008 Jun;33(7):1746-59. Epub 2007 Sep 26.

PMID:
17895918
[PubMed - indexed for MEDLINE]
Free Article
13.

Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception.

Cahill CM, Morinville A, Lee MC, Vincent JP, Collier B, Beaudet A.

J Neurosci. 2001 Oct 1;21(19):7598-607.

PMID:
11567050
[PubMed - indexed for MEDLINE]
Free Article
14.

TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.

Lantero A, Tramullas M, Pílar-Cuellar F, Valdizán E, Santillán R, Roques BP, Hurlé MA.

J Neurosci. 2014 Apr 9;34(15):5385-95. doi: 10.1523/JNEUROSCI.4405-13.2014.

PMID:
24719115
[PubMed - indexed for MEDLINE]
Free Article
15.

A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers.

Fan T, Varghese G, Nguyen T, Tse R, O'Dowd BF, George SR.

J Biol Chem. 2005 Nov 18;280(46):38478-88. Epub 2005 Sep 13.

PMID:
16159882
[PubMed - indexed for MEDLINE]
Free Article
16.

Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors.

Rutherford JM, Wang J, Xu H, Dersch CM, Partilla JS, Rice KC, Rothman RB.

Peptides. 2008 Aug;29(8):1424-31. doi: 10.1016/j.peptides.2008.03.019. Epub 2008 Apr 8.

PMID:
18472184
[PubMed - indexed for MEDLINE]
17.

Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.

Matthes HW, Smadja C, Valverde O, Vonesch JL, Foutz AS, Boudinot E, Denavit-Saubié M, Severini C, Negri L, Roques BP, Maldonado R, Kieffer BL.

J Neurosci. 1998 Sep 15;18(18):7285-95.

PMID:
9736649
[PubMed - indexed for MEDLINE]
Free Article
18.

Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.

Wang Q, Liu-Chen LY, Traynor JR.

J Biol Chem. 2009 Jul 3;284(27):18357-67. doi: 10.1074/jbc.M109.015453. Epub 2009 May 5.

PMID:
19416973
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice.

Morinville A, Cahill CM, Esdaile MJ, Aibak H, Collier B, Kieffer BL, Beaudet A.

J Neurosci. 2003 Jun 15;23(12):4888-98.

PMID:
12832511
[PubMed - indexed for MEDLINE]
Free Article
20.

Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action.

Kim KS, Lee KW, Lee KW, Im JY, Yoo JY, Kim SW, Lee JK, Nestler EJ, Han PL.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3908-13. Epub 2006 Feb 28.

PMID:
16537460
[PubMed - indexed for MEDLINE]
Free PMC Article

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