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Results: 1 to 20 of 100

1.

Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice.

Shen HC, Ylaya K, Pechhold K, Wilson A, Adem A, Hewitt SM, Libutti SK.

Endocrinology. 2010 Aug;151(8):4024-30. doi: 10.1210/en.2009-1251. Epub 2010 Jun 16.

PMID:
20555035
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

Lu J, Herrera PL, Carreira C, Bonnavion R, Seigne C, Calender A, Bertolino P, Zhang CX.

Gastroenterology. 2010 May;138(5):1954-65. doi: 10.1053/j.gastro.2010.01.046. Epub 2010 Feb 2.

PMID:
20138042
[PubMed - indexed for MEDLINE]
3.

Of mice and MEN1: Insulinomas in a conditional mouse knockout.

Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS.

Mol Cell Biol. 2003 Sep;23(17):6075-85.

PMID:
12917331
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Gene expression profiling in insulinomas of Men1 beta-cell mutant mice reveals early genetic and epigenetic events involved in pancreatic beta-cell tumorigenesis.

Fontanière S, Tost J, Wierinckx A, Lachuer J, Lu J, Hussein N, Busato F, Gut I, Wang ZQ, Zhang CX.

Endocr Relat Cancer. 2006 Dec;13(4):1223-36.

PMID:
17158767
[PubMed - indexed for MEDLINE]
Free Article
5.

Analysis of p27(Kip1) expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice.

Fontanière S, Casse H, Bertolino P, Zhang CX.

Fam Cancer. 2006;5(1):49-54.

PMID:
16528608
[PubMed - indexed for MEDLINE]
6.

Oncogenic co-operation in beta-cell tumorigenesis.

Pelengaris S, Khan M.

Endocr Relat Cancer. 2001 Dec;8(4):307-14. Review.

PMID:
11733227
[PubMed - indexed for MEDLINE]
Free Article
7.

Altered MENIN expression disrupts the MAFA differentiation pathway in insulinoma.

Hamze Z, Vercherat C, Bernigaud-Lacheretz A, Bazzi W, Bonnavion R, Lu J, Calender A, Pouponnot C, Bertolino P, Roche C, Stein R, Scoazec JY, Zhang CX, Cordier-Bussat M.

Endocr Relat Cancer. 2013 Oct 24;20(6):833-48. doi: 10.1530/ERC-13-0164. Print 2013 Dec.

PMID:
24157940
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice.

Bertolino P, Tong WM, Herrera PL, Casse H, Zhang CX, Wang ZQ.

Cancer Res. 2003 Aug 15;63(16):4836-41.

PMID:
12941803
[PubMed - indexed for MEDLINE]
Free Article
9.

Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability.

Scacheri PC, Kennedy AL, Chin K, Miller MT, Hodgson JG, Gray JW, Marx SJ, Spiegel AM, Collins FS.

Cancer Res. 2004 Oct 1;64(19):7039-44.

PMID:
15466197
[PubMed - indexed for MEDLINE]
Free Article
10.

Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse.

Lu J, Hamze Z, Bonnavion R, Herath N, Pouponnot C, Assade F, Fontanière S, Bertolino P, Cordier-Bussat M, Zhang CX.

Oncogene. 2012 Aug 2;31(31):3647-54. doi: 10.1038/onc.2011.538. Epub 2011 Nov 28.

PMID:
22120711
[PubMed - indexed for MEDLINE]
11.

The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators.

Shi K, Parekh VI, Roy S, Desai SS, Agarwal SK.

Endocr Relat Cancer. 2013 Feb 18;20(1):111-22. doi: 10.1530/ERC-12-0077. Print 2013 Feb.

PMID:
23419452
[PubMed - indexed for MEDLINE]
Free Article
12.

The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.

Song TY, Lim J, Kim B, Han JW, Youn HD, Cho EJ.

Biochem Biophys Res Commun. 2014 Aug 22;451(2):308-13. doi: 10.1016/j.bbrc.2014.07.113. Epub 2014 Aug 1.

PMID:
25088994
[PubMed - indexed for MEDLINE]
13.

Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.

Xie T, Chen M, Weinstein LS.

J Endocrinol. 2010 Sep;206(3):261-9. doi: 10.1677/JOE-10-0030. Epub 2010 Jun 11.

PMID:
20543009
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis.

Jones HB, Reens J, Brocklehurst SR, Betts CJ, Bickerton S, Bigley AL, Jenkins RP, Whalley NM, Morgan D, Smith DM.

Int J Exp Pathol. 2014 Feb;95(1):29-48. doi: 10.1111/iep.12066.

PMID:
24456331
[PubMed - indexed for MEDLINE]
15.

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R.

Diabetes. 2006 Feb;55(2):297-304.

PMID:
16443760
[PubMed - indexed for MEDLINE]
Free Article
16.

[The role and mechanism of high expression of cyclin B2 in MEN1 insulinoma].

Wu T, Huang XH.

Sheng Li Xue Bao. 2011 Dec 25;63(6):555-64. Chinese.

PMID:
22193451
[PubMed - indexed for MEDLINE]
Free Article
17.

Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells.

Kataoka K, Shioda S, Ando K, Sakagami K, Handa H, Yasuda K.

J Mol Endocrinol. 2004 Feb;32(1):9-20.

PMID:
14765989
[PubMed - indexed for MEDLINE]
Free Article
18.

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Lubensky IA, et al.

Cancer Res. 1997 Nov 1;57(21):4682-6.

PMID:
9354421
[PubMed - indexed for MEDLINE]
Free Article
19.

GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function.

Odori S, Hosoda K, Tomita T, Fujikura J, Kusakabe T, Kawaguchi Y, Doi R, Takaori K, Ebihara K, Sakai Y, Uemoto S, Nakao K.

Metabolism. 2013 Jan;62(1):70-8. doi: 10.1016/j.metabol.2012.06.010. Epub 2012 Aug 9.

PMID:
22883930
[PubMed - indexed for MEDLINE]
20.

Accelerated proliferation and differential global gene expression in pancreatic islets of five-week-old heterozygous Men1 mice: Men1 is a haploinsufficient suppressor.

Lejonklou MH, Barbu A, Stålberg P, Skogseid B.

Endocrinology. 2012 Jun;153(6):2588-98. doi: 10.1210/en.2011-1924. Epub 2012 Apr 4.

PMID:
22492302
[PubMed - indexed for MEDLINE]

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