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Items: 1 to 20 of 122

1.

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).

Ohnesorge N, Viemann D, Schmidt N, Czymai T, Spiering D, Schmolke M, Ludwig S, Roth J, Goebeler M, Schmidt M.

J Biol Chem. 2010 Aug 20;285(34):26199-210. doi: 10.1074/jbc.M110.103127. Epub 2010 Jun 15.

2.

Erk5 inhibits endothelial migration via KLF2-dependent down-regulation of PAK1.

Komaravolu RK, Adam C, Moonen JR, Harmsen MC, Goebeler M, Schmidt M.

Cardiovasc Res. 2015 Jan 1;105(1):86-95. doi: 10.1093/cvr/cvu236. Epub 2014 Nov 10.

3.

MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.

Clark PR, Jensen TJ, Kluger MS, Morelock M, Hanidu A, Qi Z, Tatake RJ, Pober JS.

Microcirculation. 2011 Feb;18(2):102-17. doi: 10.1111/j.1549-8719.2010.00071.x.

4.

Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats.

Wu Y, Feng B, Chen S, Zuo Y, Chakrabarti S.

Can J Physiol Pharmacol. 2010 Jun;88(6):607-15. doi: 10.1139/Y10-033.

5.

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells.

Villarreal G Jr, Zhang Y, Larman HB, Gracia-Sancho J, Koo A, García-Cardeña G.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):984-9. doi: 10.1016/j.bbrc.2009.12.002. Epub 2009 Dec 5.

6.

Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation.

Kim M, Kim S, Lim JH, Lee C, Choi HC, Woo CH.

J Biol Chem. 2012 Nov 23;287(48):40722-31. doi: 10.1074/jbc.M112.381509. Epub 2012 Oct 5.

7.

Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells.

Woo CH, Shishido T, McClain C, Lim JH, Li JD, Yang J, Yan C, Abe J.

Circ Res. 2008 Mar 14;102(5):538-45. doi: 10.1161/CIRCRESAHA.107.156877. Epub 2008 Jan 24.

8.

Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase.

Sohn SJ, Li D, Lee LK, Winoto A.

Mol Cell Biol. 2005 Oct;25(19):8553-66.

9.

Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype.

Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang G.

Breast Cancer Res. 2008;10(6):R105. doi: 10.1186/bcr2210. Epub 2008 Dec 16.

10.

Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2.

Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, Mochizuki N.

J Biol Chem. 2009 Feb 27;284(9):5592-601. doi: 10.1074/jbc.M806928200. Epub 2008 Dec 23.

11.

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.

Gracia-Sancho J, Villarreal G Jr, Zhang Y, García-Cardeña G.

Cardiovasc Res. 2010 Feb 1;85(3):514-9. doi: 10.1093/cvr/cvp337. Epub 2009 Oct 8.

12.

ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning.

Su C, Sun F, Cunningham RL, Rybalchenko N, Singh M.

Age (Dordr). 2014;36(4):9685. doi: 10.1007/s11357-014-9685-5. Epub 2014 Jul 12.

13.

Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1/ERK2 in the chemotactic response.

Hii CS, Anson DS, Costabile M, Mukaro V, Dunning K, Ferrante A.

J Biol Chem. 2004 Nov 26;279(48):49825-34. Epub 2004 Sep 20.

14.

MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.

Spiering D, Schmolke M, Ohnesorge N, Schmidt M, Goebeler M, Wegener J, Wixler V, Ludwig S.

J Biol Chem. 2009 Sep 11;284(37):24972-80. doi: 10.1074/jbc.M109.042911. Epub 2009 Jul 15.

15.

ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes.

Wu Y, Feng B, Chen S, Chakrabarti S.

Invest Ophthalmol Vis Sci. 2012 Dec 19;53(13):8405-13. doi: 10.1167/iovs.12-10553.

PMID:
23188731
16.

PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.

Nakamura K, Uhlik MT, Johnson NL, Hahn KM, Johnson GL.

Mol Cell Biol. 2006 Mar;26(6):2065-79.

17.

ERK5 and the regulation of endothelial cell function.

Roberts OL, Holmes K, Müller J, Cross DA, Cross MJ.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1254-9. doi: 10.1042/BST0371254. Review.

PMID:
19909257
18.

Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton.

Barros JC, Marshall CJ.

J Cell Sci. 2005 Apr 15;118(Pt 8):1663-71. Epub 2005 Mar 29.

19.
20.

Kruppel-like factor 4 regulates endothelial inflammation.

Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg MW, Gerzsten RE, Edelman ER, Jain MK.

J Biol Chem. 2007 May 4;282(18):13769-79. Epub 2007 Mar 5.

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