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Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.

Cawood AL, Ding R, Napper FL, Young RH, Williams JA, Ward MJ, Gudmundsen O, Vige R, Payne SP, Ye S, Shearman CP, Gallagher PJ, Grimble RF, Calder PC.

Atherosclerosis. 2010 Sep;212(1):252-9. doi: 10.1016/j.atherosclerosis.2010.05.022. Epub 2010 May 20.


Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.

Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF.

Lancet. 2003 Feb 8;361(9356):477-85.


Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids.

Rupp H, Wagner D, Rupp T, Schulte LM, Maisch B.

Herz. 2004 Nov;29(7):673-85. Review. Erratum in: Herz. 2004 Dec;29(8):805.


Preoperative oral supplementation with long-chain Omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue.

Senkal M, Haaker R, Linseisen J, Wolfram G, Homann HH, Stehle P.

JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4):236-40.


Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy.

Yusof HM, Cawood AL, Ding R, Williams JA, Napper FL, Shearman CP, Grimble RF, Payne SP, Calder PC.

Mar Drugs. 2013 Sep 20;11(9):3569-81. doi: 10.3390/md11093569.


Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse.

Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH.

Atherosclerosis. 2009 May;204(1):147-55. doi: 10.1016/j.atherosclerosis.2008.08.024. Epub 2008 Sep 2.


Eicosapentaenoic and docosahexaenoic acid supplementation and inflammatory gene expression in the duodenum of obese patients with type 2 diabetes.

Labonté MÈ, Couture P, Tremblay AJ, Hogue JC, Lemelin V, Lamarche B.

Nutr J. 2013 Jul 15;12:98. doi: 10.1186/1475-2891-12-98.


Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study.

Thusgaard M, Christensen JH, Mørn B, Andersen TS, Vige R, Arildsen H, Schmidt EB, Nielsen H.

Scand J Infect Dis. 2009;41(10):760-6. doi: 10.1080/00365540903168056.


Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans.

Browning LM, Walker CG, Mander AP, West AL, Gambell J, Madden J, Calder PC, Jebb SA.

J Nutr. 2014 May;144(5):667-72. doi: 10.3945/jn.113.186346. Epub 2014 Mar 19.


Long-chain n-3 polyunsaturated fatty acid dietary recommendations are moderately efficient in optimizing their status in healthy middle-aged subjects with low fish consumption: a cross-over study.

Djuricic ID, Mazic SD, Kotur-Stevuljevic JM, Djordjevic VR, Sobajic SS.

Nutr Res. 2014 Mar;34(3):210-8. doi: 10.1016/j.nutres.2013.12.008. Epub 2014 Jan 3.


Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).

Steffen BT, Steffen LM, Tracy R, Siscovick D, Jacobs D, Liu K, He K, Hanson NQ, Nettleton JA, Tsai MY.

Eur J Clin Nutr. 2012 May;66(5):600-5. doi: 10.1038/ejcn.2011.215. Epub 2012 Jan 4.


Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions.

Zuijdgeest-van Leeuwen SD, Dagnelie PC, Rietveld T, van den Berg JW, Wilson JH.

Br J Nutr. 1999 Dec;82(6):481-8.


Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function.

Fowler KH, Chapkin RS, McMurray DN.

J Immunol. 1993 Nov 15;151(10):5186-97.


Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men.

Rees D, Miles EA, Banerjee T, Wells SJ, Roynette CE, Wahle KW, Calder PC.

Am J Clin Nutr. 2006 Feb;83(2):331-42.


Plaque-infiltrating T lymphocytes in patients with carotid atherosclerosis: an insight into the cellular mechanisms associated to plaque destabilization.

Profumo E, Buttari B, Tosti ME, Tagliani A, Capoano R, D'Amati G, Businaro R, Salvati B, Riganò R.

J Cardiovasc Surg (Torino). 2013 Jun;54(3):349-57. Epub 2012 May 28.


Bioequivalence of two omega-3 fatty acid ethyl ester formulations: a case of clinical pharmacology of dietary supplements.

Galli C, Maggi FM, Risé P, Sirtori CR.

Br J Clin Pharmacol. 2012 Jul;74(1):60-5. doi: 10.1111/j.1365-2125.2012.04174.x.


Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish.

Browning LM, Walker CG, Mander AP, West AL, Madden J, Gambell JM, Young S, Wang L, Jebb SA, Calder PC.

Am J Clin Nutr. 2012 Oct;96(4):748-58. Epub 2012 Aug 29.

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