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Results: 1 to 20 of 102

1.

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JR, Gomberg-Maitland M, Thébaud B, Husain AN, Cipriani N, Rehman J.

Circulation. 2010 Jun 22;121(24):2661-71. doi: 10.1161/CIRCULATIONAHA.109.916098. Epub 2010 Jun 7.

PMID:
20529999
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL.

Circulation. 2006 Jun 6;113(22):2630-41. Epub 2006 May 30.

PMID:
16735674
[PubMed - indexed for MEDLINE]
Free Article
3.

Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL.

Circ Res. 2012 May 25;110(11):1484-97. doi: 10.1161/CIRCRESAHA.111.263848. Epub 2012 Apr 17.

PMID:
22511751
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.

Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H570-8. Epub 2007 Dec 14. Review.

PMID:
18083891
[PubMed - indexed for MEDLINE]
Free Article
5.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

PMID:
23525442
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Krüppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension.

Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, Bisserier M, Paulin R, Lambert C, Provencher S, Bonnet S.

Respir Res. 2011 Sep 27;12:128. doi: 10.1186/1465-9921-12-128.

PMID:
21951574
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension.

Rehman J, Archer SL.

Adv Exp Med Biol. 2010;661:171-85. doi: 10.1007/978-1-60761-500-2_11. Review.

PMID:
20204730
[PubMed - indexed for MEDLINE]
8.

Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation.

Aljubran SA, Cox R Jr, Tamarapu Parthasarathy P, Kollongod Ramanathan G, Rajanbabu V, Bao H, Mohapatra SS, Lockey R, Kolliputi N.

PLoS One. 2012;7(5):e37712. doi: 10.1371/journal.pone.0037712. Epub 2012 May 25. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/8580b50a-1556-4c86-aeb6-a88af839297a. Mohapatra, Shyam M [corrected to Mohapatra, Shyam S].

PMID:
22662197
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW.

Circ Res. 2010 Jul 23;107(2):252-62. doi: 10.1161/CIRCRESAHA.109.209940. Epub 2010 Jun 3.

PMID:
20522807
[PubMed - indexed for MEDLINE]
Free Article
10.

PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension.

Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):865-78. doi: 10.1164/rccm.201209-1687OC.

PMID:
23449689
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Role for DNA damage signaling in pulmonary arterial hypertension.

Meloche J, Pflieger A, Vaillancourt M, Paulin R, Potus F, Zervopoulos S, Graydon C, Courboulin A, Breuils-Bonnet S, Tremblay E, Couture C, Michelakis ED, Provencher S, Bonnet S.

Circulation. 2014 Feb 18;129(7):786-97. doi: 10.1161/CIRCULATIONAHA.113.006167. Epub 2013 Nov 22.

PMID:
24270264
[PubMed - indexed for MEDLINE]
Free Article
12.

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

PMID:
23139294
[PubMed - indexed for MEDLINE]
Free Article
13.

Soluble JAGGED1 inhibits pulmonary hypertension by attenuating notch signaling.

Xiao Y, Gong D, Wang W.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2733-9. doi: 10.1161/ATVBAHA.113.302062. Epub 2013 Sep 26.

PMID:
24072692
[PubMed - indexed for MEDLINE]
Free Article
14.

Involvement of Gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells.

Xia S, Tai X, Wang Y, An X, Qian G, Dong J, Wang X, Sha B, Wang D, Murthi P, Kalionis B, Wang X, Bai C.

Am J Respir Cell Mol Biol. 2011 Jan;44(1):66-73. doi: 10.1165/rcmb.2008-0442OC. Epub 2010 Feb 16.

PMID:
20160044
[PubMed - indexed for MEDLINE]
15.

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED.

Circ Res. 2004 Oct 15;95(8):830-40. Epub 2004 Sep 16.

PMID:
15375007
[PubMed - indexed for MEDLINE]
Free Article
16.

Manganese superoxide dismutase inhibits neointima formation through attenuation of migration and proliferation of vascular smooth muscle cells.

Wang JN, Shi N, Chen SY.

Free Radic Biol Med. 2012 Jan 1;52(1):173-81. doi: 10.1016/j.freeradbiomed.2011.10.442. Epub 2011 Oct 24.

PMID:
22062629
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Intermedin modulates hypoxic pulmonary vascular remodeling by inhibiting pulmonary artery smooth muscle cell proliferation.

Mao SZ, Fan XF, Xue F, Chen R, Chen XY, Yuan GS, Hu LG, Liu SF, Gong YS.

Pulm Pharmacol Ther. 2014 Feb;27(1):1-9. doi: 10.1016/j.pupt.2013.06.004. Epub 2013 Jun 22.

PMID:
23796770
[PubMed - indexed for MEDLINE]
18.

Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.

Yang J, Li X, Li Y, Southwood M, Ye L, Long L, Al-Lamki RS, Morrell NW.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L312-21. doi: 10.1152/ajplung.00054.2013. Epub 2013 Jun 14.

PMID:
23771884
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension.

McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED.

J Clin Invest. 2005 Jun;115(6):1479-91.

PMID:
15931388
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.

Zhou RH, Vendrov AE, Tchivilev I, Niu XL, Molnar KC, Rojas M, Carter JD, Tong H, Stouffer GA, Madamanchi NR, Runge MS.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):745-55. doi: 10.1161/ATVBAHA.111.243121. Epub 2011 Dec 22.

PMID:
22199367
[PubMed - indexed for MEDLINE]
Free PMC Article
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