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Results: 1 to 20 of 154

1.

Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity.

Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T.

J Neurochem. 2011 Jan;116(2):192-204. doi: 10.1111/j.1471-4159.2010.06824.x.

PMID:
20492361
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein.

He L, Zhang Z, Yu Y, Ahmed S, Cheung NS, Qi RZ.

Cell Mol Life Sci. 2011 May;68(9):1633-43. doi: 10.1007/s00018-010-0562-9. Epub 2010 Oct 26.

PMID:
20976519
[PubMed - indexed for MEDLINE]
3.

p35/p25 is not essential for tau and cytoskeletal pathology or neuronal loss in Niemann-Pick type C disease.

Hallows JL, Iosif RE, Biasell RD, Vincent I.

J Neurosci. 2006 Mar 8;26(10):2738-44.

PMID:
16525053
[PubMed - indexed for MEDLINE]
Free Article
4.

A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.

Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC.

J Biol Chem. 2010 Oct 29;285(44):34202-12. doi: 10.1074/jbc.M110.134643. Epub 2010 Aug 18.

PMID:
20720012
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.

Kanungo J, Zheng YL, Amin ND, Pant HC.

J Neurochem. 2008 Sep;106(5):2236-48. doi: 10.1111/j.1471-4159.2008.05551.x. Epub 2008 Jul 4.

PMID:
18662245
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator.

Hisanaga S, Saito T.

Neurosignals. 2003 Sep-Oct;12(4-5):221-9. Review.

PMID:
14673209
[PubMed - indexed for MEDLINE]
7.

Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE.

Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga S.

Mol Cell Proteomics. 2010 Jun;9(6):1133-43. doi: 10.1074/mcp.M900578-MCP200. Epub 2010 Jan 23.

PMID:
20097924
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Resveratrol inhibits Cdk5 activity through regulation of p35 expression.

Utreras E, Terse A, Keller J, Iadarola MJ, Kulkarni AB.

Mol Pain. 2011 Jul 7;7:49. doi: 10.1186/1744-8069-7-49.

PMID:
21736731
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

Sundaram JR, Poore CP, Sulaimee NH, Pareek T, Asad AB, Rajkumar R, Cheong WF, Wenk MR, Dawe GS, Chuang KH, Pant HC, Kesavapany S.

J Neurosci. 2013 Jan 2;33(1):334-43. doi: 10.1523/JNEUROSCI.3593-12.2013.

PMID:
23283346
[PubMed - indexed for MEDLINE]
Free Article
10.
11.

Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.

Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S.

J Neurosci. 2008 Aug 27;28(35):8747-55. doi: 10.1523/JNEUROSCI.0973-08.2008.

PMID:
18753376
[PubMed - indexed for MEDLINE]
Free Article
12.

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S.

J Neurochem. 2011 May;117(3):504-15. doi: 10.1111/j.1471-4159.2011.07222.x. Epub 2011 Mar 15.

PMID:
21338355
[PubMed - indexed for MEDLINE]
13.

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T.

J Neurosci. 2008 Dec 31;28(53):14511-21. doi: 10.1523/JNEUROSCI.3417-08.2008.

PMID:
19118186
[PubMed - indexed for MEDLINE]
Free Article
14.

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis.

Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttilä T.

Biochem Biophys Res Commun. 2001 Feb 2;280(4):998-1002.

PMID:
11162625
[PubMed - indexed for MEDLINE]
15.

Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

Sato K, Zhu YS, Saito T, Yotsumoto K, Asada A, Hasegawa M, Hisanaga S.

J Neurosci Res. 2007 Nov 1;85(14):3071-8.

PMID:
17671990
[PubMed - indexed for MEDLINE]
16.

Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35.

Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY.

J Biol Chem. 2002 Aug 30;277(35):31988-93. Epub 2002 Jun 25.

PMID:
12084709
[PubMed - indexed for MEDLINE]
Free Article
17.

Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain.

Ramos-Miguel A, GarcĂ­a-Sevilla JA.

Neuroscience. 2012 Jul 26;215:17-30. doi: 10.1016/j.neuroscience.2012.04.035. Epub 2012 Apr 23.

PMID:
22537847
[PubMed - indexed for MEDLINE]
18.

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

Kesavapany S, Zheng YL, Amin N, Pant HC.

Biotechnol J. 2007 Aug;2(8):978-87. Review.

PMID:
17526058
[PubMed - indexed for MEDLINE]
19.

The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling.

He Y, Kastin AJ, Hsuchou H, Pan W.

J Mol Neurosci. 2009 Sep;39(1-2):49-58. doi: 10.1007/s12031-008-9174-3. Epub 2009 Jan 21.

PMID:
19156541
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation.

Zhu YS, Saito T, Asada A, Maekawa S, Hisanaga S.

J Neurochem. 2005 Sep;94(6):1535-45. Epub 2005 Jun 30.

PMID:
15992363
[PubMed - indexed for MEDLINE]

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