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Results: 1 to 20 of 129

1.

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.

J Biol Chem. 2010 Jun 25;285(26):20303-15. doi: 10.1074/jbc.M110.114413. Epub 2010 Apr 20.

PMID:
20406807
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.

McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M.

J Biol Chem. 2008 Nov 14;283(46):31802-12. doi: 10.1074/jbc.M805843200. Epub 2008 Sep 18.

PMID:
18801737
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Identification of the LEDGF/p75 binding site in HIV-1 integrase.

Busschots K, Voet A, De Maeyer M, Rain JC, Emiliani S, Benarous R, Desender L, Debyser Z, Christ F.

J Mol Biol. 2007 Feb 2;365(5):1480-92. Epub 2006 Nov 3.

PMID:
17137594
[PubMed - indexed for MEDLINE]
4.

Computational studies of the interaction between the HIV-1 integrase tetramer and the cofactor LEDGF/p75: insights from molecular dynamics simulations and the informational spectrum method.

Tintori C, Veljkovic N, Veljkovic V, Botta M.

Proteins. 2010 Dec;78(16):3396-408. doi: 10.1002/prot.22847. Epub 2010 Sep 27.

PMID:
20878714
[PubMed - indexed for MEDLINE]
5.

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.

Tsiang M, Jones GS, Hung M, Mukund S, Han B, Liu X, Babaoglu K, Lansdon E, Chen X, Todd J, Cai T, Pagratis N, Sakowicz R, Geleziunas R.

J Biol Chem. 2009 Nov 27;284(48):33580-99. doi: 10.1074/jbc.M109.040121. Epub 2009 Sep 28.

PMID:
19801648
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.

Zheng Y, Ao Z, Jayappa KD, Yao X.

Virol J. 2010 Mar 23;7:68. doi: 10.1186/1743-422X-7-68.

PMID:
20331877
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.

Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z.

J Biol Chem. 2003 Jan 3;278(1):372-81. Epub 2002 Oct 28.

PMID:
12407101
[PubMed - indexed for MEDLINE]
Free Article
8.

Insights into the interactions between HIV-1 integrase and human LEDGF/p75 by molecular dynamics simulation and free energy calculation.

Zhao Y, Li W, Zeng J, Liu G, Tang Y.

Proteins. 2008 Aug;72(2):635-45. doi: 10.1002/prot.21955.

PMID:
18247352
[PubMed - indexed for MEDLINE]
9.

Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.

Garcia-Rivera JA, Bueno MT, Morales E, Kugelman JR, Rodriguez DF, Llano M.

J Virol. 2010 Jan;84(2):740-52. doi: 10.1128/JVI.01043-09. Epub 2009 Nov 4.

PMID:
19889764
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

Bartholomeeusen K, Christ F, Hendrix J, Rain JC, Emiliani S, Benarous R, Debyser Z, Gijsbers R, De Rijck J.

J Biol Chem. 2009 Apr 24;284(17):11467-77. doi: 10.1074/jbc.M807781200. Epub 2009 Feb 25.

PMID:
19244240
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

Christ F, Debyser Z.

Virology. 2013 Jan 5;435(1):102-9. doi: 10.1016/j.virol.2012.09.033. Review. Erratum in: Virology. 2013 Mar 30;438(1):50.

PMID:
23217620
[PubMed - indexed for MEDLINE]
Free Article
12.

Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.

Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N.

FEBS Lett. 2008 Apr 30;582(10):1425-30. doi: 10.1016/j.febslet.2008.02.076. Epub 2008 Mar 10.

PMID:
18331842
[PubMed - indexed for MEDLINE]
Free Article
13.

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

Cherepanov P, Devroe E, Silver PA, Engelman A.

J Biol Chem. 2004 Nov 19;279(47):48883-92. Epub 2004 Sep 14.

PMID:
15371438
[PubMed - indexed for MEDLINE]
Free Article
14.

Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.

De Luca L, Ferro S, Morreale F, De Grazia S, Chimirri A.

ChemMedChem. 2011 Jul 4;6(7):1184-91. doi: 10.1002/cmdc.201100071. Epub 2011 Apr 19. Review.

PMID:
21506277
[PubMed - indexed for MEDLINE]
15.

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M.

J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24.

PMID:
23615903
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F.

J Mol Biol. 2007 Sep 14;372(2):407-21. Epub 2007 Jul 12.

PMID:
17669426
[PubMed - indexed for MEDLINE]
17.
18.

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.

Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne M.

Nucleic Acids Res. 2008 Mar;36(4):1237-46. doi: 10.1093/nar/gkm1127. Epub 2008 Jan 3.

PMID:
18174227
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM.

J Mol Biol. 2006 Jul 21;360(4):760-73. Epub 2006 May 17.

PMID:
16793062
[PubMed - indexed for MEDLINE]
20.

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y.

J Biol Chem. 2003 Aug 29;278(35):33528-39. Epub 2003 Jun 9.

PMID:
12796494
[PubMed - indexed for MEDLINE]
Free Article

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