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Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.

Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC.

Thyroid. 2010 May;20(5):545-53. doi: 10.1089/thy.2009.0318.


Thyroid hormone receptor-beta-selective agonist GC-24 spares skeletal muscle type I to II fiber shift.

Miyabara EH, Aoki MS, Soares AG, Saltao RM, Vilicev CM, Passarelli M, Scanlan TS, Gouveia CH, Moriscot AS.

Cell Tissue Res. 2005 Aug;321(2):233-41. Epub 2005 Jun 10.


Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.

Villicev CM, Freitas FR, Aoki MS, Taffarel C, Scanlan TS, Moriscot AS, Ribeiro MO, Bianco AC, Gouveia CH.

J Endocrinol. 2007 Apr;193(1):21-9.


Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.

Ye L, Li YL, Mellström K, Mellin C, Bladh LG, Koehler K, Garg N, Garcia Collazo AM, Litten C, Husman B, Persson K, Ljunggren J, Grover G, Sleph PG, George R, Malm J.

J Med Chem. 2003 Apr 24;46(9):1580-8.


Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes.

Grover GJ, Mellström K, Malm J.

Curr Vasc Pharmacol. 2007 Apr;5(2):141-54. Review.


A TRbeta-selective agonist confers resistance to diet-induced obesity.

Amorim BS, Ueta CB, Freitas BC, Nassif RJ, Gouveia CH, Christoffolete MA, Moriscot AS, Lancelloti CL, Llimona F, Barbeiro HV, de Souza HP, Catanozi S, Passarelli M, Aoki MS, Bianco AC, Ribeiro MO.

J Endocrinol. 2009 Nov;203(2):291-9. doi: 10.1677/JOE-08-0539. Epub 2009 Aug 27.


Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141.

Bryzgalova G, Effendic S, Khan A, Rehnmark S, Barbounis P, Boulet J, Dong G, Singh R, Shapses S, Malm J, Webb P, Baxter JD, Grover GJ.

J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):262-7. doi: 10.1016/j.jsbmb.2008.06.010. Epub 2008 Jun 22.


Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.

Murase T, Misawa K, Haramizu S, Minegishi Y, Hase T.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E266-75. doi: 10.1152/ajpendo.00774.2009. Epub 2010 May 25.


Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats.

Perra A, Simbula G, Simbula M, Pibiri M, Kowalik MA, Sulas P, Cocco MT, Ledda-Columbano GM, Columbano A.

FASEB J. 2008 Aug;22(8):2981-9. doi: 10.1096/fj.08-108464. Epub 2008 Apr 23.


Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats.

Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y.

J Ethnopharmacol. 2006 Jun 30;106(2):238-44. Epub 2006 Feb 21.


Effects of thyroid hormone analogs on lipid metabolism and thermogenesis.

Ribeiro MO.

Thyroid. 2008 Feb;18(2):197-203. doi: 10.1089/thy.2007.0288. Review.


Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.

Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. Epub 2007 Sep 18.


The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells.

Beber EH, Capelo LP, Fonseca TL, Costa CC, Lotfi CF, Scanlan TS, Gouveia CH.

Calcif Tissue Int. 2009 Apr;84(4):324-33. doi: 10.1007/s00223-009-9230-1. Epub 2009 Mar 11.


A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model.

Choi H, Eo H, Park K, Jin M, Park EJ, Kim SH, Park JE, Kim S.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):419-25. Epub 2007 May 25. Erratum in: Biochem Biophys Res Commun. 2008 Feb 1;366(1):269.


Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice.

Oh KS, Ryu SY, Lee S, Seo HW, Oh BK, Kim YS, Lee BH.

J Ethnopharmacol. 2009 Mar 18;122(2):216-20.


Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae Tokoronis on high-fat diet-induced obesity in mice.

Song MY, Lv N, Kim EK, Kwon KS, Yoo YB, Kim JH, Lee SW, Song JH, Lee JH, Lee SK, Shin BC, Ryu DG, Park BH, Kwon KB.

J Med Food. 2009 Apr;12(2):304-9. doi: 10.1089/jmf.2008.1010.


Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.

Guan XM, Chen H, Dobbelaar PH, Dong Y, Fong TM, Gagen K, Gorski J, He S, Howard AD, Jian T, Jiang M, Kan Y, Kelly TM, Kosinski J, Lin LS, Liu J, Marsh DJ, Metzger JM, Miller R, Nargund RP, Palyha O, Shearman L, Shen Z, Stearns R, Strack AM, Stribling S, Tang YS, Wang SP, White A, Yu H, Reitman ML.

Cell Metab. 2010 Feb 3;11(2):101-12. doi: 10.1016/j.cmet.2009.12.008. Epub 2010 Jan 21.


Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).

Park JS, Rhee SD, Kang NS, Jung WH, Kim HY, Kim JH, Kang SK, Cheon HG, Ahn JH, Kim KY.

Biochem Pharmacol. 2011 Apr 15;81(8):1028-35. doi: 10.1016/j.bcp.2011.01.020. Epub 2011 Feb 18.

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