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Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.

Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF.

Thorax. 2010 Apr;65(4):346-53. doi: 10.1136/thx.2008.101139.


Requirement of heat shock protein 70 for inducible nitric oxide synthase induction.

Zhang L, Liu Q, Yuan X, Wang T, Luo S, Lei H, Xia Y.

Cell Signal. 2013 May;25(5):1310-7. doi: 10.1016/j.cellsig.2013.02.004. Epub 2013 Feb 16.


Obligatory role of heat shock protein 90 in iNOS induction.

Luo S, Wang T, Qin H, Lei H, Xia Y.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C227-33. doi: 10.1152/ajpcell.00493.2010. Epub 2011 Mar 23.


Interleukin-4-mediated inhibition of nitric oxide production in interferon-gamma-treated and virus-infected macrophages.

Paludan SR, Ellermann-Eriksen S, Lovmand J, Mogensen SC.

Scand J Immunol. 1999 Feb;49(2):169-76.


TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.

Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T.

Genes Cells. 2006 Aug;11(8):871-82.


Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages.

Salonen T, Sareila O, Jalonen U, Kankaanranta H, Tuominen R, Moilanen E.

Br J Pharmacol. 2006 Apr;147(7):790-9.


Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2.

Weber SM, Scarim AL, Corbett JA.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E883-91. Epub 2003 Jan 7.


Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase.

Yoshida M, Xia Y.

J Biol Chem. 2003 Sep 19;278(38):36953-8. Epub 2003 Jul 10.


PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

Paukkeri EL, Leppänen T, Sareila O, Vuolteenaho K, Kankaanranta H, Moilanen E.

Br J Pharmacol. 2007 Dec;152(7):1081-91. Epub 2007 Sep 24.


Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

Chen JC, Ho FM, Pei-Dawn Lee Chao, Chen CP, Jeng KC, Hsu HB, Lee ST, Wen Tung Wu, Lin WW.

Eur J Pharmacol. 2005 Oct 3;521(1-3):9-20. Epub 2005 Sep 19.


Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide.

Llovera M, Pearson JD, Moreno C, Riveros-Moreno V.

Br J Pharmacol. 2001 Jan;132(2):419-26.


STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells.

Liu PW, Chen MF, Tsai AP, Lee TJ.

PLoS One. 2012;7(12):e50363. doi: 10.1371/journal.pone.0050363. Epub 2012 Dec 6.

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