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Items: 1 to 20 of 516

1.

Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.

Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, Xu Z, Dong W, Qin Y, Fei G, Zhong C, Xu TL.

Brain. 2010 May;133(Pt 5):1342-51. doi: 10.1093/brain/awq069. Epub 2010 Apr 12.

2.

Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice.

Arendash GW, Mori T, Cao C, Mamcarz M, Runfeldt M, Dickson A, Rezai-Zadeh K, Tane J, Citron BA, Lin X, Echeverria V, Potter H.

J Alzheimers Dis. 2009;17(3):661-80. doi: 10.3233/JAD-2009-1087.

PMID:
19581722
3.

A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.

Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC.

J Alzheimers Dis. 2010;20(1):113-26. doi: 10.3233/JAD-2010-1349.

PMID:
20164597
4.

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

Neurosci Lett. 2009 Mar 13;452(2):90-5. doi: 10.1016/j.neulet.2009.01.013. Epub 2009 Jan 13.

PMID:
19154776
5.

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.

J Neurochem. 2011 Dec;119(6):1330-40. doi: 10.1111/j.1471-4159.2011.07532.x. Epub 2011 Nov 2.

6.

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease.

Richard KL, Filali M, Préfontaine P, Rivest S.

J Neurosci. 2008 May 28;28(22):5784-93. doi: 10.1523/JNEUROSCI.1146-08.2008.

7.

Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.

He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li X, Li XM.

Neurobiol Aging. 2009 Aug;30(8):1205-16. Epub 2008 Feb 20.

PMID:
18079026
8.

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.

Peng Y, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.

J Alzheimers Dis. 2012;29(2):379-91. doi: 10.3233/JAD-2011-111577.

PMID:
22233765
9.

Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice.

Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, Runfeldt M, Shytle RD, Tan J.

Brain Res. 2008 Jun 12;1214:177-87. doi: 10.1016/j.brainres.2008.02.107. Epub 2008 Apr 7.

PMID:
18457818
10.

Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden.

Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, Van Groen T, Tanila H, Koistinaho J.

J Neurosci. 2007 Apr 4;27(14):3712-21.

11.

Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities.

Savonenko A, Xu GM, Melnikova T, Morton JL, Gonzales V, Wong MP, Price DL, Tang F, Markowska AL, Borchelt DR.

Neurobiol Dis. 2005 Apr;18(3):602-17.

PMID:
15755686
12.

Amyloid beta and impairment in multiple memory systems in older transgenic APP TgCRND8 mice.

Hanna A, Horne P, Yager D, Eckman C, Eckman E, Janus C.

Genes Brain Behav. 2009 Oct;8(7):676-84. doi: 10.1111/j.1601-183X.2009.00510.x. Epub 2009 May 26.

13.

Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.

Howlett DR, Bowler K, Soden PE, Riddell D, Davis JB, Richardson JC, Burbidge SA, Gonzalez MI, Irving EA, Lawman A, Miglio G, Dawson EL, Howlett ER, Hussain I.

Histol Histopathol. 2008 Jan;23(1):67-76.

PMID:
17952859
14.

Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease.

Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S.

Brain. 2009 Apr;132(Pt 4):1078-92. doi: 10.1093/brain/awn331. Epub 2009 Jan 17.

15.

Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice.

Härtig W, Goldhammer S, Bauer U, Wegner F, Wirths O, Bayer TA, Grosche J.

J Chem Neuroanat. 2010 Sep;40(1):82-92. doi: 10.1016/j.jchemneu.2010.03.006. Epub 2010 Mar 25.

PMID:
20347032
16.

Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice.

Dragicevic N, Mamcarz M, Zhu Y, Buzzeo R, Tan J, Arendash GW, Bradshaw PC.

J Alzheimers Dis. 2010;20 Suppl 2:S535-50. doi: 10.3233/JAD-2010-100342.

PMID:
20463404
17.

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels.

Pardon MC, Sarmad S, Rattray I, Bates TE, Scullion GA, Marsden CA, Barrett DA, Lowe J, Kendall DA.

Neurobiol Aging. 2009 Jul;30(7):1099-113. Epub 2007 Nov 26.

PMID:
18023506
18.

Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.

Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.

Neuroscience. 2006 Nov 3;142(4):941-52. Epub 2006 Aug 28.

PMID:
16938404
19.

Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.

Ding Y, Qiao A, Fan GH.

Neurobiol Dis. 2010 Aug;39(2):156-68. doi: 10.1016/j.nbd.2010.03.022. Epub 2010 Apr 8.

PMID:
20381617
20.

Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation.

Yang X, Yang Y, Li G, Wang J, Yang ES.

J Mol Neurosci. 2008 Feb;34(2):165-71. doi: 10.1007/s12031-007-9033-7. Epub 2008 Jan 5.

PMID:
18181031
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