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Items: 1 to 20 of 82

1.

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis.

Lucking AJ, Visvanathan A, Philippou H, Fraser S, Grant PJ, Connolly TM, Gardell SJ, Feuerstein GZ, Fox KA, Booth NA, Newby DE.

J Thromb Haemost. 2010 Jun;8(6):1333-9. doi: 10.1111/j.1538-7836.2010.03872.x. Epub 2010 Mar 25.

2.

Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy.

Crandall DL, Elokdah H, Di L, Hennan JK, Gorlatova NV, Lawrence DA.

J Thromb Haemost. 2004 Aug;2(8):1422-8.

4.

Highly stable plasminogen activator inhibitor type one (VLHL PAI-1) protects fibrin clots from tissue plasminogen activator-mediated fibrinolysis.

Jankun J, Aleem AM, Selman SH, Skrzypczak-Jankun E, Lysiak-Szydlowska W, Grafos N, Fryer HJ, Greenfield RS.

Int J Mol Med. 2007 Nov;20(5):683-7.

PMID:
17912461
5.

The roles of alpha 2-antiplasmin and plasminogen activator inhibitor 1 (PAI-1) in the inhibition of clot lysis.

Robbie LA, Booth NA, Croll AM, Bennett B.

Thromb Haemost. 1993 Aug 2;70(2):301-6.

PMID:
8236139
7.

Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action.

Gardell SJ, Krueger JA, Antrilli TA, Elokdah H, Mayer S, Orcutt SJ, Crandall DL, Vlasuk GP.

Mol Pharmacol. 2007 Oct;72(4):897-906. Epub 2007 Jul 10.

8.

Gemfibrozil treatment of combined hyperlipoproteinemia. No improvement of fibrinolysis despite marked reduction of plasma triglyceride levels.

Bröijersen A, Eriksson M, Wiman B, Angelin B, Hjemdahl P.

Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):511-6.

9.

Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis.

Hennan JK, Elokdah H, Leal M, Ji A, Friedrichs GS, Morgan GA, Swillo RE, Antrilli TM, Hreha A, Crandall DL.

J Pharmacol Exp Ther. 2005 Aug;314(2):710-6. Epub 2005 Apr 28.

11.

Effects of imidapril therapy on endogenous fibrinolysis in patients with recent myocardial infarction.

Soejima H, Ogawa H, Yasue H, Suefuji H, Kaikita K, Nishiyama K.

Clin Cardiol. 1997 May;20(5):441-5.

13.

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms.

Fay WP, Eitzman DT, Shapiro AD, Madison EL, Ginsburg D.

Blood. 1994 Jan 15;83(2):351-6.

14.

Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives.

Meijers JC, Middeldorp S, Tekelenburg W, van den Ende AE, Tans G, Prins MH, Rosing J, Büller HR, Bouma BN.

Thromb Haemost. 2000 Jul;84(1):9-14.

PMID:
10928462
15.

The -675 4G/5G polymorphism at the Plasminogen Activator Inhibitor 1 (PAI-1) gene modulates plasma Plasminogen Activator Inhibitor 1 concentrations in response to dietary fat consumption.

Pérez-Martínez P, Adarraga-Cansino MD, Fernández de la Puebla RA, Blanco-Molina A, Delgado-Lista J, Marín C, Ordovás JM, López-Miranda J, Pérez-Jiménez F.

Br J Nutr. 2008 Apr;99(4):699-702. Epub 2007 Oct 1.

PMID:
17903340
16.

Effect of organic nitrates on ex vivo platelet aggregation and fibrinolysis in man.

Wolfram G, Meyer U, Scheske U, Horn M, Drummer C, Spannagl M, Gerzer R.

Eur J Med Res. 1996 Mar 19;1(6):291-8.

PMID:
9367942
17.

Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits.

Friederich PW, Levi M, Biemond BJ, Charlton P, Templeton D, van Zonneveld AJ, Bevan P, Pannekoek H, ten Cate JW.

Circulation. 1997 Aug 5;96(3):916-21.

PMID:
9264501
18.

Effect of isotretinoin on endogenous tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in humans.

Wallnöfer AE, van Griensven JM, Schoemaker HC, Cohen AF, Lambert W, Kluft C, Meijer P, Kooistra T.

Thromb Haemost. 1993 Dec 20;70(6):1005-8.

PMID:
8165591
19.

Regulation of plasminogen activator inhibitor activity by plasmin in endothelial cells.

Shi GY, Wang SJ, Chang B, Tasi CF, Lin MT, Chang WC, Wing LY, Jen CJ, Wu HL.

Thromb Res. 1996 Jan 1;81(1):75-84.

PMID:
8747522
20.

Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1.

Pahor M, Franse LV, Deitcher SR, Cushman WC, Johnson KC, Shorr RI, Kottke-Marchant K, Tracy RP, Somes GW, Applegate WB.

Circulation. 2002 Jan 29;105(4):457-61.

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