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Items: 1 to 20 of 147


B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy.

Palazzolo I, Nedelsky NB, Askew CE, Harmison GG, Kasantsev AG, Taylor JP, Fischbeck KH, Pennuto M.

J Neurosci Res. 2010 Aug 1;88(10):2207-16. doi: 10.1002/jnr.22389.


Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy.

Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS, Finkbeiner S, Merry DE.

Hum Mol Genet. 2009 Jun 1;18(11):1937-50. doi: 10.1093/hmg/ddp115. Epub 2009 Mar 11.


CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G.

J Neurosci. 2007 May 9;27(19):5115-26.


[Triplet repeat disease, with particular emphasis of spinal and bulbar muscular atrophy (SBMA)].

Sobue G.

Rinsho Shinkeigaku. 2000 Dec;40(12):1193-5. Japanese.


An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.

Orr CR, Montie HL, Liu Y, Bolzoni E, Jenkins SC, Wilson EM, Joseph JD, McDonnell DP, Merry DE.

J Biol Chem. 2010 Nov 12;285(46):35567-77. doi: 10.1074/jbc.M110.146845. Epub 2010 Sep 8.


New routes to therapy for spinal and bulbar muscular atrophy.

Rocchi A, Pennuto M.

J Mol Neurosci. 2013 Jul;50(3):514-23. doi: 10.1007/s12031-013-9978-7. Epub 2013 Feb 19. Review.


Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target.

Furutani T, Takeyama K, Tanabe M, Koutoku H, Ito S, Taniguchi N, Suzuki E, Kudoh M, Shibasaki M, Shikama H, Kato S.

J Pharmacol Exp Ther. 2005 Nov;315(2):545-52. Epub 2005 Aug 3. Retraction in: J Pharmacol Exp Ther. 2014 Mar;348(3):493.


Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives.

Katsuno M, Adachi H, Tanaka F, Sobue G.

J Mol Med (Berl). 2004 May;82(5):298-307. Epub 2004 Feb 27. Review.


Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy.

Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL.

Endocrinology. 2014 Jul;155(7):2624-34. doi: 10.1210/en.2013-1756. Epub 2014 Apr 17.


Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA).

Katsuno M, Tanaka F, Adachi H, Banno H, Suzuki K, Watanabe H, Sobue G.

Prog Neurobiol. 2012 Dec;99(3):246-56. doi: 10.1016/j.pneurobio.2012.05.007. Epub 2012 May 15. Review.


Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy.

Thomas PS Jr, Fraley GS, Damian V, Woodke LB, Zapata F, Sopher BL, Plymate SR, La Spada AR.

Hum Mol Genet. 2006 Jul 15;15(14):2225-38. Epub 2006 Jun 13. Erratum in: Hum Mol Genet. 2006 Oct 1;15(19):2972. Damien, Vincent [corrected to Damian, Vincent].


Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA.

Montie HL, Merry DE.

Autophagy. 2009 Nov;5(8):1194-7. Epub 2009 Nov 3.


Proteasomal and autophagic degradative activities in spinal and bulbar muscular atrophy.

Rusmini P, Bolzoni E, Crippa V, Onesto E, Sau D, Galbiati M, Piccolella M, Poletti A.

Neurobiol Dis. 2010 Nov;40(2):361-9. doi: 10.1016/j.nbd.2010.06.016. Epub 2010 Jul 16. Review.


Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G.

Brain. 2005 Mar;128(Pt 3):659-70. Epub 2005 Jan 19.


Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy.

Giorgetti E, Rusmini P, Crippa V, Cristofani R, Boncoraglio A, Cicardi ME, Galbiati M, Poletti A.

Hum Mol Genet. 2015 Jan 1;24(1):64-75. doi: 10.1093/hmg/ddu419. Epub 2014 Aug 13.


Neurotoxic effects of androgens in spinal and bulbar muscular atrophy.

Parodi S, Pennuto M.

Front Neuroendocrinol. 2011 Oct;32(4):416-25. doi: 10.1016/j.yfrne.2011.06.003. Epub 2011 Jul 1. Review.


Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy.

Nihei Y, Ito D, Okada Y, Akamatsu W, Yagi T, Yoshizaki T, Okano H, Suzuki N.

J Biol Chem. 2013 Mar 22;288(12):8043-52. doi: 10.1074/jbc.M112.408211. Epub 2013 Jan 30.


SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

Montie HL, Pestell RG, Merry DE.

J Neurosci. 2011 Nov 30;31(48):17425-36. doi: 10.1523/JNEUROSCI.3958-11.2011.


Proteasome-mediated proteolysis of the polyglutamine-expanded androgen receptor is a late event in spinal and bulbar muscular atrophy (SBMA) pathogenesis.

Heine EM, Berger TR, Pluciennik A, Orr CR, Zboray L, Merry DE.

J Biol Chem. 2015 May 15;290(20):12572-84. doi: 10.1074/jbc.M114.617894. Epub 2015 Mar 20.

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