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Items: 1 to 20 of 92

1.

Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.

Li BF, Moree WJ, Yu J, Coon T, Zamani-Kord S, Malany S, Jalali K, Wen J, Wang H, Yang C, Hoare SR, Petroski RE, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2629-33. doi: 10.1016/j.bmcl.2010.02.055. Epub 2010 Feb 18.

PMID:
20227880
2.

Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.

Moree WJ, Li BF, Zamani-Kord S, Yu J, Coon T, Huang C, Marinkovic D, Tucci FC, Malany S, Bradbury MJ, Hernandez LM, Wen J, Wang H, Hoare SR, Petroski RE, Jalali K, Yang C, Sacaan A, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5874-8. doi: 10.1016/j.bmcl.2010.07.117. Epub 2010 Aug 3.

PMID:
20800486
3.

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

Moree WJ, Li BF, Jovic F, Coon T, Yu J, Gross RS, Tucci F, Marinkovic D, Zamani-Kord S, Malany S, Bradbury MJ, Hernandez LM, O'Brien Z, Wen J, Wang H, Hoare SR, Petroski RE, Sacaan A, Madan A, Crowe PD, Beaton G.

J Med Chem. 2009 Sep 10;52(17):5307-10. doi: 10.1021/jm900933k.

PMID:
19663387
4.

Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.

Coon T, Moree WJ, Li B, Yu J, Zamani-Kord S, Malany S, Santos MA, Hernandez LM, Petroski RE, Sun A, Wen J, Sullivan S, Haelewyn J, Hedrick M, Hoare SJ, Bradbury MJ, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4380-4. doi: 10.1016/j.bmcl.2009.05.086. Epub 2009 May 27.

PMID:
19553115
5.

The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.

Lavrador-Erb K, Ravula SB, Yu J, Zamani-Kord S, Moree WJ, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9. doi: 10.1016/j.bmcl.2010.03.027. Epub 2010 Mar 10.

PMID:
20347297
7.

Structure-activity relationships of dimethindene derivatives as new M2-selective muscarinic receptor antagonists.

Böhme TM, Keim C, Kreutzmann K, Linder M, Dingermann T, Dannhardt G, Mutschler E, Lambrecht G.

J Med Chem. 2003 Feb 27;46(5):856-67.

PMID:
12593665
8.

Drugs for insomnia.

[No authors listed]

Treat Guidel Med Lett. 2012 Jul;10(119):57-60. No abstract available.

PMID:
22777275
9.
10.

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.

Ravula SB, Yu J, Tran JA, Arellano M, Tucci FC, Moree WJ, Li BF, Petroski RE, Wen J, Malany S, Hoare SR, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):421-6. doi: 10.1016/j.bmcl.2011.10.115. Epub 2011 Nov 15.

PMID:
22153347
11.

Insomnia: drug treatment.

Tsoi WF.

Ann Acad Med Singapore. 1991 Mar;20(2):269-72. Review.

PMID:
1679317
12.

Novel benzothiophene H1-antihistamines for the treatment of insomnia.

Moree WJ, Jovic F, Coon T, Yu J, Li BF, Tucci FC, Marinkovic D, Gross RS, Malany S, Bradbury MJ, Hernandez LM, O'Brien Z, Wen J, Wang H, Hoare SR, Petroski RE, Sacaan A, Madan A, Crowe PD, Beaton G.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2316-20. doi: 10.1016/j.bmcl.2010.01.134. Epub 2010 Feb 2.

PMID:
20188547
13.

Ramelteon: a novel approach in the treatment of insomnia.

Reynoldson JN, Elliott E Sr, Nelson LA.

Ann Pharmacother. 2008 Sep;42(9):1262-71. doi: 10.1345/aph.1K676. Epub 2008 Jul 23. Review.

PMID:
18648020
14.

Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia.

Roth T, Seiden D, Sainati S, Wang-Weigand S, Zhang J, Zee P.

Sleep Med. 2006 Jun;7(4):312-8. Epub 2006 May 18.

PMID:
16709464
15.

Emerging drugs for insomnia: new frontiers for old and novel targets.

Sullivan SS, Guilleminault C.

Expert Opin Emerg Drugs. 2009 Sep;14(3):411-22. doi: 10.1517/14728210903171948. Review.

PMID:
19708818
16.

Fresh from the pipeline: Ramelteon.

Buysse D, Bate G, Kirkpatrick P.

Nat Rev Drug Discov. 2005 Nov;4(11):881-2. No abstract available.

PMID:
16299918
17.

Ramelteon for the treatment of insomnia.

Borja NL, Daniel KL.

Clin Ther. 2006 Oct;28(10):1540-55. Review.

PMID:
17157111
18.

Clinically important drug interactions with zopiclone, zolpidem and zaleplon.

Hesse LM, von Moltke LL, Greenblatt DJ.

CNS Drugs. 2003;17(7):513-32. Review.

PMID:
12751920
19.

Ramelteon (Rozerem) for insomnia.

[No authors listed]

Med Lett Drugs Ther. 2005 Nov 7;47(1221):89-91. No abstract available.

PMID:
16267494
20.

The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.

Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, Bozyczko-Coyne D, Spiegel K, Ohtsu H, Williams M, Lin JS.

Biochem Pharmacol. 2007 Apr 15;73(8):1157-71. Epub 2007 Jan 7.

PMID:
17288995
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