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Results: 1 to 20 of 102

1.

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.

Remacle AG, Gawlik K, Golubkov VS, Cadwell GW, Liddington RC, Cieplak P, Millis SZ, Desjardins R, Routhier S, Yuan XW, Neugebauer WA, Day R, Strongin AY.

Int J Biochem Cell Biol. 2010 Jun;42(6):987-95. doi: 10.1016/j.biocel.2010.02.013. Epub 2010 Mar 1.

PMID:
20197107
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

Gawlik K, Remacle AG, Shiryaev SA, Golubkov VS, Ouyang M, Wang Y, Strongin AY.

PLoS One. 2010 Jun 24;5(6):e11305. doi: 10.1371/journal.pone.0011305.

PMID:
20585585
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.

PMID:
17537721
[PubMed - indexed for MEDLINE]
Free Article
4.

Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.

Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, Day R, Smith JW, Lebl M, Strongin AY.

J Biol Chem. 2008 Jul 25;283(30):20897-906. doi: 10.1074/jbc.M803762200. Epub 2008 May 27.

PMID:
18505722
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.

Chekanov AV, Remacle AG, Golubkov VS, Akatov VS, Sikora S, Savinov AY, Fugere M, Day R, Rozanov DV, Strongin AY.

Arch Biochem Biophys. 2006 Feb 1;446(1):52-9. Epub 2005 Dec 7.

PMID:
16384550
[PubMed - indexed for MEDLINE]
6.

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Klimpel KR, Molloy SS, Thomas G, Leppla SH.

Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10277-81.

PMID:
1438214
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes.

Friedman TC, Gordon VM, Leppla SH, Klimpel KR, Birch NP, Loh YP.

Arch Biochem Biophys. 1995 Jan 10;316(1):5-13.

PMID:
7840657
[PubMed - indexed for MEDLINE]
8.

Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein.

Zhang Y, Kida Y, Kuwano K, Misumi Y, Ikehara Y, Arai S.

Microbiol Immunol. 2001;45(2):119-25.

PMID:
11293477
[PubMed - indexed for MEDLINE]
9.

Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules.

Komiyama T, Coppola JM, Larsen MJ, van Dort ME, Ross BD, Day R, Rehemtulla A, Fuller RS.

J Biol Chem. 2009 Jun 5;284(23):15729-38. doi: 10.1074/jbc.M901540200. Epub 2009 Mar 30.

PMID:
19332539
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

Molloy SS, Bresnahan PA, Leppla SH, Klimpel KR, Thomas G.

J Biol Chem. 1992 Aug 15;267(23):16396-402.

PMID:
1644824
[PubMed - indexed for MEDLINE]
Free Article
11.

Cross-inhibition between furin and lethal factor inhibitors.

Peinado JR, Kacprzak MM, Leppla SH, Lindberg I.

Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5.

PMID:
15358148
[PubMed - indexed for MEDLINE]
12.

Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.

Sarac MS, Peinado JR, Leppla SH, Lindberg I.

Infect Immun. 2004 Jan;72(1):602-5.

PMID:
14688144
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.

Kacprzak MM, Peinado JR, Than ME, Appel J, Henrich S, Lipkind G, Houghten RA, Bode W, Lindberg I.

J Biol Chem. 2004 Aug 27;279(35):36788-94. Epub 2004 Jun 14.

PMID:
15197180
[PubMed - indexed for MEDLINE]
Free Article
14.
15.

Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication.

Opal SM, Artenstein AW, Cristofaro PA, Jhung JW, Palardy JE, Parejo NA, Lim YP.

Infect Immun. 2005 Aug;73(8):5101-5.

PMID:
16041026
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.

Beierlein JM, Anderson AC.

Curr Med Chem. 2011;18(33):5083-94. Review.

PMID:
22050756
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.

Komiyama T, Swanson JA, Fuller RS.

Antimicrob Agents Chemother. 2005 Sep;49(9):3875-82.

PMID:
16127065
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.

Smith K, Crowe SR, Garman L, Guthridge CJ, Muther JJ, McKee E, Zheng NY, Farris AD, Guthridge JM, Wilson PC, James JA.

Vaccine. 2012 Jun 13;30(28):4276-83. doi: 10.1016/j.vaccine.2012.03.002. Epub 2012 Mar 14.

PMID:
22425791
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Selection and evaluation of the immunogenicity of protective antigen mutants as anthrax vaccine candidates.

Yan M, Roehrl MH, Basar E, Wang JY.

Vaccine. 2008 Feb 13;26(7):947-55. doi: 10.1016/j.vaccine.2007.11.087. Epub 2007 Dec 26.

PMID:
18192092
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

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