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Results: 1 to 20 of 117

Related Citations for PubMed (Select 20178741)

1.

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.

Cell. 2010 Feb 19;140(4):477-90. doi: 10.1016/j.cell.2010.01.029.

2.

Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression.

Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.

Sci Signal. 2011 Aug 23;4(188):pt6. doi: 10.1126/scisignal.2002314.

PMID:
21878678
3.

Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1).

Li W, Giancotti FG.

Cell Cycle. 2010 Nov 15;9(22):4433-6. Epub 2010 Nov 15.

4.

Molecular insights into NF2/Merlin tumor suppressor function.

Cooper J, Giancotti FG.

FEBS Lett. 2014 Aug 19;588(16):2743-52. doi: 10.1016/j.febslet.2014.04.001. Epub 2014 Apr 12. Review.

PMID:
24726726
5.

Merlin, a multi-suppressor from cell membrane to the nucleus.

Zhou L, Hanemann CO.

FEBS Lett. 2012 May 21;586(10):1403-8. doi: 10.1016/j.febslet.2012.03.016. Epub 2012 Mar 21. Review.

6.
7.

Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.

Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG.

Cancer Cell. 2014 Jul 14;26(1):48-60. doi: 10.1016/j.ccr.2014.05.001.

PMID:
25026211
8.

Point mutation in the NF2 gene of HEI-193 human schwannoma cells results in the expression of a merlin isoform with attenuated growth suppressive activity.

Lepont P, Stickney JT, Foster LA, Meng JJ, Hennigan RF, Ip W.

Mutat Res. 2008 Jan 1;637(1-2):142-51. Epub 2007 Aug 6.

9.

Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1.

Li Y, Wei Z, Zhang J, Yang Z, Zhang M.

J Biol Chem. 2014 May 23;289(21):14674-81. doi: 10.1074/jbc.M114.551184. Epub 2014 Apr 4.

PMID:
24706749
10.

VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Huang J, Chen J.

Oncogene. 2008 Jul 3;27(29):4056-64. doi: 10.1038/onc.2008.44. Epub 2008 Mar 10.

PMID:
18332868
11.

NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.

James MF, Han S, Polizzano C, Plotkin SR, Manning BD, Stemmer-Rachamimov AO, Gusella JF, Ramesh V.

Mol Cell Biol. 2009 Aug;29(15):4250-61. doi: 10.1128/MCB.01581-08. Epub 2009 May 18.

12.

Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.

Rong R, Tang X, Gutmann DH, Ye K.

Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18200-5. Epub 2004 Dec 14.

13.

Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus.

Chen H, Mei L, Zhou L, Zhang X, Guo C, Li J, Wang H, Zhu Y, Zheng Y, Huang L.

Int J Biochem Cell Biol. 2011 Apr;43(4):545-55. doi: 10.1016/j.biocel.2010.12.011. Epub 2010 Dec 15.

PMID:
21167305
14.

Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.

Li W, Cooper J, Karajannis MA, Giancotti FG.

EMBO Rep. 2012 Mar;13(3):204-15. Review.

15.

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.

Gutmann DH, Sherman L, Seftor L, Haipek C, Hoang Lu K, Hendrix M.

Hum Mol Genet. 1999 Feb;8(2):267-75.

16.
17.

Functional inactivation of NF2/merlin in human mesothelioma.

Thurneysen C, Opitz I, Kurtz S, Weder W, Stahel RA, Felley-Bosco E.

Lung Cancer. 2009 May;64(2):140-7. doi: 10.1016/j.lungcan.2008.08.014. Epub 2008 Oct 4.

PMID:
18835652
18.

The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.

Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A.

Neoplasia. 2008 Nov;10(11):1204-12.

19.

Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK.

Poulikakos PI, Xiao GH, Gallagher R, Jablonski S, Jhanwar SC, Testa JR.

Oncogene. 2006 Sep 28;25(44):5960-8. Epub 2006 May 1.

PMID:
16652148
20.

Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.

Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK.

Neoplasia. 2012 Feb;14(2):84-94.

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