Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 103

1.

Characterization of an atypical gamma-secretase complex from hematopoietic origin.

Placanica L, Chien JW, Li YM.

Biochemistry. 2010 Apr 6;49(13):2796-804. doi: 10.1021/bi901388t.

2.

Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.

Boo JH, Sohn JH, Kim JE, Song H, Mook-Jung I.

Biochem Biophys Res Commun. 2008 Aug 8;372(4):913-7. doi: 10.1016/j.bbrc.2008.05.153. Epub 2008 Jun 5.

PMID:
18538664
3.

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G.

J Biol Chem. 2010 Dec 3;285(49):38042-52. doi: 10.1074/jbc.M110.132613. Epub 2010 Oct 4.

4.

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, Greengard P.

Nature. 2010 Sep 2;467(7311):95-8. doi: 10.1038/nature09325.

5.

An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.

Tian Y, Bassit B, Chau D, Li YM.

Nat Struct Mol Biol. 2010 Feb;17(2):151-8. doi: 10.1038/nsmb.1743. Epub 2010 Jan 10.

PMID:
20062056
6.

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM.

Biochemistry. 2009 Nov 24;48(46):10894-904. doi: 10.1021/bi901237k.

7.

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H.

J Neurochem. 2013 Apr;125(1):144-56. doi: 10.1111/jnc.12124. Epub 2013 Jan 15.

8.

Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.

Tian Y, Crump CJ, Li YM.

J Biol Chem. 2010 Oct 15;285(42):32549-56. doi: 10.1074/jbc.M110.128439. Epub 2010 Jul 30.

9.

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH.

J Biol Chem. 2011 Nov 18;286(46):39794-803. doi: 10.1074/jbc.M111.277228. Epub 2011 Aug 25.

10.

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.

Biochemistry. 2009 Feb 17;48(6):1183-97. doi: 10.1021/bi801204g.

PMID:
19159235
11.

Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).

Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH.

J Biol Chem. 2012 Nov 23;287(48):40629-40. doi: 10.1074/jbc.M112.418442. Epub 2012 Oct 5.

12.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

13.

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

Neurobiol Dis. 2007 Jul;27(1):102-7. Epub 2007 May 6.

PMID:
17560791
15.

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T.

J Biol Chem. 2009 Dec 25;284(52):36024-33. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28.

16.

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.

J Biol Chem. 2005 Jul 22;280(29):27303-9. Epub 2005 May 25.

18.

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.

Barthet G, Shioi J, Shao Z, Ren Y, Georgakopoulos A, Robakis NK.

FASEB J. 2011 Sep;25(9):2937-46. doi: 10.1096/fj.11-183806. Epub 2011 May 19.

19.

γ-Secretase inhibitors and modulators.

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L.

Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Review.

20.

Spatial segregation of gamma-secretase and substrates in distinct membrane domains.

Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G.

J Biol Chem. 2005 Jul 8;280(27):25892-900. Epub 2005 May 10.

Items per page

Supplemental Content

Write to the Help Desk