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A central role for the WH2 domain of Srv2/CAP in recharging actin monomers to drive actin turnover in vitro and in vivo.

Chaudhry F, Little K, Talarico L, Quintero-Monzon O, Goode BL.

Cytoskeleton (Hoboken). 2010 Feb;67(2):120-33. doi: 10.1002/cm.20429.


Reconstitution and dissection of the 600-kDa Srv2/CAP complex: roles for oligomerization and cofilin-actin binding in driving actin turnover.

Quintero-Monzon O, Jonasson EM, Bertling E, Talarico L, Chaudhry F, Sihvo M, Lappalainen P, Goode BL.

J Biol Chem. 2009 Apr 17;284(16):10923-34. doi: 10.1074/jbc.M808760200. Epub 2009 Feb 6.


Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1.

Balcer HI, Goodman AL, Rodal AA, Smith E, Kugler J, Heuser JE, Goode BL.

Curr Biol. 2003 Dec 16;13(24):2159-69.


A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein.

Mattila PK, Quintero-Monzon O, Kugler J, Moseley JB, Almo SC, Lappalainen P, Goode BL.

Mol Biol Cell. 2004 Nov;15(11):5158-71. Epub 2004 Sep 8.


Mechanism and biological role of profilin-Srv2/CAP interaction.

Bertling E, Quintero-Monzon O, Mattila PK, Goode BL, Lappalainen P.

J Cell Sci. 2007 Apr 1;120(Pt 7):1225-34.


Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.

Jansen S, Collins A, Golden L, Sokolova O, Goode BL.

J Biol Chem. 2014 Oct 31;289(44):30732-42. doi: 10.1074/jbc.M114.601765. Epub 2014 Sep 16.


Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin.

Chaudhry F, Breitsprecher D, Little K, Sharov G, Sokolova O, Goode BL.

Mol Biol Cell. 2013 Jan;24(1):31-41. doi: 10.1091/mbc.E12-08-0589. Epub 2012 Nov 7.


Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism.

Makkonen M, Bertling E, Chebotareva NA, Baum J, Lappalainen P.

J Biol Chem. 2013 Jan 11;288(2):984-94. doi: 10.1074/jbc.M112.435719. Epub 2012 Nov 26.


WH2 domain: a small, versatile adapter for actin monomers.

Paunola E, Mattila PK, Lappalainen P.

FEBS Lett. 2002 Feb 20;513(1):92-7. Review.


Autonomous and in trans functions for the two halves of Srv2/CAP in promoting actin turnover.

Chaudhry F, Jansen S, Little K, Suarez C, Boujemaa-Paterski R, Blanchoin L, Goode BL.

Cytoskeleton (Hoboken). 2014 Jun;71(6):351-60. doi: 10.1002/cm.21170. Epub 2014 Apr 25.


High-speed depolymerization at actin filament ends jointly catalysed by Twinfilin and Srv2/CAP.

Johnston AB, Collins A, Goode BL.

Nat Cell Biol. 2015 Nov;17(11):1504-11. doi: 10.1038/ncb3252. Epub 2015 Oct 12.


Biochemical Activities of the Wiskott-Aldrich Syndrome Homology Region 2 Domains of Sarcomere Length Short (SALS) Protein.

Tóth MÁ, Majoros AK, Vig AT, Migh E, Nyitrai M, Mihály J, Bugyi B.

J Biol Chem. 2016 Jan 8;291(2):667-80. doi: 10.1074/jbc.M115.683904. Epub 2015 Nov 17.


Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly.

Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16644-9. Epub 2005 Nov 7.


Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain.

Mattila PK, Salminen M, Yamashiro T, Lappalainen P.

J Biol Chem. 2003 Mar 7;278(10):8452-9. Epub 2002 Dec 13.


Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin.

Gottwald U, Brokamp R, Karakesisoglou I, Schleicher M, Noegel AA.

Mol Biol Cell. 1996 Feb;7(2):261-72.


Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.

Irobi E, Aguda AH, Larsson M, Guerin C, Yin HL, Burtnick LD, Blanchoin L, Robinson RC.

EMBO J. 2004 Sep 15;23(18):3599-608. Epub 2004 Aug 26.


The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.

Heimsath EG Jr, Higgs HN.

J Biol Chem. 2012 Jan 27;287(5):3087-98. doi: 10.1074/jbc.M111.312207. Epub 2011 Nov 17.


Identification of Arabidopsis cyclase-associated protein 1 as the first nucleotide exchange factor for plant actin.

Chaudhry F, Guérin C, von Witsch M, Blanchoin L, Staiger CJ.

Mol Biol Cell. 2007 Aug;18(8):3002-14. Epub 2007 May 30.


Mutagenetic and electron microscopy analysis of actin filament severing by Cordon-Bleu, a WH2 domain protein.

Jiao Y, Walker M, Trinick J, Pernier J, Montaville P, Carlier MF.

Cytoskeleton (Hoboken). 2014 Mar;71(3):170-83. doi: 10.1002/cm.21161. Epub 2014 Mar 12.

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