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Results: 1 to 20 of 104

1.

Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation.

Cippitelli A, Damadzic R, Frankola K, Goldstein A, Thorsell A, Singley E, Eskay RL, Heilig M.

Biol Psychiatry. 2010 May 1;67(9):823-30. doi: 10.1016/j.biopsych.2009.12.018. Epub 2010 Feb 4.

PMID:
20132926
[PubMed - indexed for MEDLINE]
2.

Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo.

Bond A, Jones NM, Hicks CA, Whiffin GM, Ward MA, O'Neill MF, Kingston AE, Monn JA, Ornstein PL, Schoepp DD, Lodge D, O'Neill MJ.

J Pharmacol Exp Ther. 2000 Sep;294(3):800-9.

PMID:
10945827
[PubMed - indexed for MEDLINE]
Free Article
3.

Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain.

Di Liberto V, Bonomo A, Frinchi M, Belluardo N, Mudò G.

Neuroscience. 2010 Feb 3;165(3):863-73. doi: 10.1016/j.neuroscience.2009.11.012. Epub 2009 Nov 10.

PMID:
19909793
[PubMed - indexed for MEDLINE]
4.

Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing.

Jones CK, Eberle EL, Peters SC, Monn JA, Shannon HE.

Neuropharmacology. 2005;49 Suppl 1:206-18.

PMID:
15998527
[PubMed - indexed for MEDLINE]
5.

Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat.

Imre G, Salomons A, Jongsma M, Fokkema DS, Den Boer JA, Ter Horst GJ.

Pharmacol Biochem Behav. 2006 Jul;84(3):392-9. Epub 2006 Jul 18.

PMID:
16857251
[PubMed - indexed for MEDLINE]
6.

Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a Group II metabotropic glutamate receptor agonist.

Cai Z, Xiao F, Fratkin JD, Rhodes PG.

Neuroreport. 1999 Dec 16;10(18):3927-31.

PMID:
10716235
[PubMed - indexed for MEDLINE]
7.

Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268.

Johnson MP, Chamberlain M.

Neuropharmacology. 2002 Oct;43(5):799-808.

PMID:
12384165
[PubMed - indexed for MEDLINE]
8.

Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG.

Bäckström P, Hyytiä P.

Eur J Pharmacol. 2005 Dec 28;528(1-3):110-8. Epub 2005 Dec 1.

PMID:
16324694
[PubMed - indexed for MEDLINE]
9.

Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.

Stover JF, Sakowitz OW, Beyer TF, Dohse NK, Kroppenstedt SN, Thomale UW, Schaser KD, Unterberg AW.

J Neurotrauma. 2003 Apr;20(4):315-26.

PMID:
12866811
[PubMed - indexed for MEDLINE]
10.

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.

Matrisciano F, Caruso A, Orlando R, Marchiafava M, Bruno V, Battaglia G, Gruber SH, Melchiorri D, Tatarelli R, Girardi P, Mathè AA, Nicoletti F.

Neuropharmacology. 2008 Sep;55(4):525-31. doi: 10.1016/j.neuropharm.2008.05.014. Epub 2008 May 24.

PMID:
18590921
[PubMed - indexed for MEDLINE]
11.

Seizures induced in immature rats by homocysteic acid and the associated brain damage are prevented by group II metabotropic glutamate receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate.

Folbergrová J, Druga R, Otáhal J, Haugvicová R, Mares P, Kubová H.

Exp Neurol. 2005 Apr;192(2):420-36.

PMID:
15755559
[PubMed - indexed for MEDLINE]
12.

Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge.

Fell MJ, Katner JS, Johnson BG, Khilevich A, Schkeryantz JM, Perry KW, Svensson KA.

Neuropharmacology. 2010 Mar;58(3):632-9. doi: 10.1016/j.neuropharm.2009.11.014. Epub 2009 Dec 3.

PMID:
19951716
[PubMed - indexed for MEDLINE]
13.

The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats.

Peters J, Kalivas PW.

Psychopharmacology (Berl). 2006 Jun;186(2):143-9. Epub 2006 Apr 22.

PMID:
16703399
[PubMed - indexed for MEDLINE]
14.

Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure.

Zhao YN, Wang F, Fan YX, Ping GF, Yang JY, Wu CF.

Behav Brain Res. 2013 Jan 1;236(1):270-82. doi: 10.1016/j.bbr.2012.08.052. Epub 2012 Sep 5.

PMID:
22985845
[PubMed - indexed for MEDLINE]
15.

Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex.

Okamura N, Hashimoto K, Shimizu E, Koike K, Ohgake S, Koizumi H, Kumakiri C, Komatsu N, Iyo M.

Brain Res. 2003 Nov 28;992(1):114-9.

PMID:
14604779
[PubMed - indexed for MEDLINE]
16.

Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes.

Durand D, Caruso C, Carniglia L, Lasaga M.

J Neurochem. 2010 Jan;112(2):420-33. doi: 10.1111/j.1471-4159.2009.06469.x.

PMID:
20085613
[PubMed - indexed for MEDLINE]
17.

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

Cartmell J, Monn JA, Schoepp DD.

J Pharmacol Exp Ther. 1999 Oct;291(1):161-70.

PMID:
10490900
[PubMed - indexed for MEDLINE]
Free Article
18.

Tolerance to the motor impairment, but not to the reversal of PCP-induced motor activities by oral administration of the mGlu2/3 receptor agonist, LY379268.

Cartmell J, Monn JA, Schoepp DD.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):39-46.

PMID:
10651145
[PubMed - indexed for MEDLINE]
19.

Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence.

Hao Y, Martin-Fardon R, Weiss F.

Biol Psychiatry. 2010 Aug 1;68(3):240-8. doi: 10.1016/j.biopsych.2010.02.011. Epub 2010 Apr 22.

PMID:
20416862
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.

Obernier JA, White AM, Swartzwelder HS, Crews FT.

Pharmacol Biochem Behav. 2002 Jun;72(3):521-32.

PMID:
12175448
[PubMed - indexed for MEDLINE]
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