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Results: 1 to 20 of 112

1.

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Karlberg T, Hammarström M, Schütz P, Svensson L, Schüler H.

Biochemistry. 2010 Feb 16;49(6):1056-8. doi: 10.1021/bi902079y.

PMID:
20092359
[PubMed - indexed for MEDLINE]
2.

Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.

Perkins E, Sun D, Nguyen A, Tulac S, Francesco M, Tavana H, Nguyen H, Tugendreich S, Barthmaier P, Couto J, Yeh E, Thode S, Jarnagin K, Jain A, Morgans D, Melese T.

Cancer Res. 2001 May 15;61(10):4175-83.

PMID:
11358842
[PubMed - indexed for MEDLINE]
Free Article
3.

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites.

Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO.

Nucleic Acids Res. 2009 Jun;37(11):3723-38. doi: 10.1093/nar/gkp229. Epub 2009 Apr 16.

PMID:
19372272
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

Hassa PO, Hottiger MO.

Front Biosci. 2008 Jan 1;13:3046-82. Review.

PMID:
17981777
[PubMed - indexed for MEDLINE]
5.

Binding mode of novel 1-substituted quinazoline derivatives to poly(ADP-ribose) polymerase-catalytic domain, revealed by X-ray crystal structure analysis of complexes.

Matsumoto K, Kondo K, Ota T, Kawashima A, Kitamura K, Ishida T.

Biochim Biophys Acta. 2006 May;1764(5):913-9. Epub 2006 Apr 3.

PMID:
16631419
[PubMed - indexed for MEDLINE]
6.

Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.

Costantino G, Macchiarulo A, Camaioni E, Pellicciari R.

J Med Chem. 2001 Nov 8;44(23):3786-94.

PMID:
11689065
[PubMed - indexed for MEDLINE]
7.

Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling.

Ruf A, de Murcia G, Schulz GE.

Biochemistry. 1998 Mar 17;37(11):3893-900.

PMID:
9521710
[PubMed - indexed for MEDLINE]
8.

Poly(ADP-ribose) polymerase inhibitors.

Southan GJ, Szabó C.

Curr Med Chem. 2003 Feb;10(4):321-40. Review.

PMID:
12570705
[PubMed - indexed for MEDLINE]
9.

Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair.

Dantzer F, Amé JC, Schreiber V, Nakamura J, Ménissier-de Murcia J, de Murcia G.

Methods Enzymol. 2006;409:493-510.

PMID:
16793420
[PubMed - indexed for MEDLINE]
10.

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.

Lehtiö L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T.

J Med Chem. 2009 May 14;52(9):3108-11. doi: 10.1021/jm900052j.

PMID:
19354255
[PubMed - indexed for MEDLINE]
11.

Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase.

White AW, Almassy R, Calvert AH, Curtin NJ, Griffin RJ, Hostomsky Z, Maegley K, Newell DR, Srinivasan S, Golding BT.

J Med Chem. 2000 Nov 2;43(22):4084-97.

PMID:
11063605
[PubMed - indexed for MEDLINE]
12.

Effect of simulated microgravity conditions on poly(ADP-ribose) polymerase activity in primary cultures of adult rat hepatocytes.

Cesarone CF, Pippia P, Demori I, Scarabelli L, Fugassa E.

J Gravit Physiol. 2001 Jul;8(1):P127-8.

PMID:
12650200
[PubMed - indexed for MEDLINE]
13.

Poly(ADP-ribose)polymerase inhibition - where now?

Woon EC, Threadgill MD.

Curr Med Chem. 2005;12(20):2373-92. Review.

PMID:
16181138
[PubMed - indexed for MEDLINE]
14.

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

Ruf A, Mennissier de Murcia J, de Murcia G, Schulz GE.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7481-5.

PMID:
8755499
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases.

Han S, Tainer JA.

Int J Med Microbiol. 2002 Feb;291(6-7):523-9. Review.

PMID:
11890553
[PubMed - indexed for MEDLINE]
16.

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B.

Mol Cell. 2008 Oct 10;32(1):57-69. doi: 10.1016/j.molcel.2008.08.009.

PMID:
18851833
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models.

Albert JM, Cao C, Kim KW, Willey CD, Geng L, Xiao D, Wang H, Sandler A, Johnson DH, Colevas AD, Low J, Rothenberg ML, Lu B.

Clin Cancer Res. 2007 May 15;13(10):3033-42.

PMID:
17505006
[PubMed - indexed for MEDLINE]
Free Article
18.

An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.

Liu X, Palma J, Kinders R, Shi Y, Donawho C, Ellis PA, Rodriguez LE, Colon-Lopez M, Saltarelli M, LeBlond D, Lin CT, Frost DJ, Luo Y, Giranda VL.

Anal Biochem. 2008 Oct 15;381(2):240-7. doi: 10.1016/j.ab.2008.07.007. Epub 2008 Jul 16.

PMID:
18674509
[PubMed - indexed for MEDLINE]
19.

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death.

Ying W, Sevigny MB, Chen Y, Swanson RA.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12227-32.

PMID:
11593040
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.

Wahlberg E, Karlberg T, Kouznetsova E, Markova N, Macchiarulo A, Thorsell AG, Pol E, Frostell Å, Ekblad T, Öncü D, Kull B, Robertson GM, Pellicciari R, Schüler H, Weigelt J.

Nat Biotechnol. 2012 Feb 19;30(3):283-8. doi: 10.1038/nbt.2121.

PMID:
22343925
[PubMed - indexed for MEDLINE]
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