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Results: 1 to 20 of 124

1.

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

Morris JP 4th, Cano DA, Sekine S, Wang SC, Hebrok M.

J Clin Invest. 2010 Feb;120(2):508-20. doi: 10.1172/JCI40045. Epub 2010 Jan 11.

PMID:
20071774
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

von Figura G, Morris JP 4th, Wright CV, Hebrok M.

Gut. 2014 Apr;63(4):656-64. doi: 10.1136/gutjnl-2012-304287. Epub 2013 May 3.

PMID:
23645620
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

PMID:
23891977
[PubMed - indexed for MEDLINE]
4.

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.

Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF.

Oncogene. 2013 Apr 11;32(15):1950-8. doi: 10.1038/onc.2012.210. Epub 2012 Jun 4.

PMID:
22665051
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

PMID:
23999170
[PubMed - indexed for MEDLINE]
6.

Notch signaling is required for exocrine regeneration after acute pancreatitis.

Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F, Schmid RM.

Gastroenterology. 2008 Feb;134(2):544-55. doi: 10.1053/j.gastro.2007.11.003. Epub 2007 Nov 4.

PMID:
18242220
[PubMed - indexed for MEDLINE]
7.

Stabilization of beta-catenin induces pancreas tumor formation.

Heiser PW, Cano DA, Landsman L, Kim GE, Kench JG, Klimstra DS, Taketo MM, Biankin AV, Hebrok M.

Gastroenterology. 2008 Oct;135(4):1288-300. doi: 10.1053/j.gastro.2008.06.089. Epub 2008 Jul 9.

PMID:
18725219
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.

Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18913-8. doi: 10.1073/pnas.0810097105. Epub 2008 Nov 21.

PMID:
19028870
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
[PubMed - indexed for MEDLINE]
10.

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.

De La O JP, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB, Murtaugh LC.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18907-12. doi: 10.1073/pnas.0810111105. Epub 2008 Nov 21.

PMID:
19028876
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
[PubMed - indexed for MEDLINE]
12.

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Flandez M, Cendrowski J, Cañamero M, Salas A, del Pozo N, Schoonjans K, Real FX.

Gut. 2014 Apr;63(4):647-55. doi: 10.1136/gutjnl-2012-304381. Epub 2013 Apr 18.

PMID:
23598351
[PubMed - indexed for MEDLINE]
13.

Notch1 is not required for acinar-to-ductal metaplasia in a model of Kras-induced pancreatic ductal adenocarcinoma.

Avila JL, Troutman S, Durham A, Kissil JL.

PLoS One. 2012;7(12):e52133. doi: 10.1371/journal.pone.0052133. Epub 2012 Dec 19.

PMID:
23284900
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.

Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF.

Am J Pathol. 2007 Jul;171(1):263-73.

PMID:
17591971
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

β-catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice.

Keefe MD, Wang H, De La O JP, Khan A, Firpo MA, Murtaugh LC.

Dis Model Mech. 2012 Jul;5(4):503-14. doi: 10.1242/dmm.007799. Epub 2012 Jan 19.

PMID:
22266944
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma.

Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP 4th, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M.

Cancer Cell. 2012 Dec 11;22(6):737-50. doi: 10.1016/j.ccr.2012.10.025. Epub 2012 Nov 29.

PMID:
23201164
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I.

J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.

PMID:
19585519
[PubMed - indexed for MEDLINE]
18.

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.

Collins MA, Bednar F, Zhang Y, Brisset JC, Galbán S, Galbán CJ, Rakshit S, Flannagan KS, Adsay NV, Pasca di Magliano M.

J Clin Invest. 2012 Feb 1;122(2):639-53. doi: 10.1172/JCI59227. Epub 2012 Jan 9.

PMID:
22232209
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.

von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M.

Nat Cell Biol. 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23.

PMID:
24561622
[PubMed - indexed for MEDLINE]
20.

Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions.

Carrière C, Gore AJ, Norris AM, Gunn JR, Young AL, Longnecker DS, Korc M.

Gastroenterology. 2011 Sep;141(3):1091-101. doi: 10.1053/j.gastro.2011.05.041. Epub 2011 May 27.

PMID:
21699781
[PubMed - indexed for MEDLINE]
Free PMC Article

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