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Items: 1 to 20 of 131

1.

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

Hailfinger S, Lenz G, Ngo V, Posvitz-Fejfar A, Rebeaud F, Guzzardi M, Penas EM, Dierlamm J, Chan WC, Staudt LM, Thome M.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19946-51. doi: 10.1073/pnas.0907511106. Epub 2009 Nov 6. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2677.

2.

Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.

Ferch U, Kloo B, Gewies A, Pfänder V, Düwel M, Peschel C, Krappmann D, Ruland J.

J Exp Med. 2009 Oct 26;206(11):2313-20. doi: 10.1084/jem.20091167. Epub 2009 Oct 19. Erratum in: J Exp Med. 2009 Nov 23;206(12):2851.

3.

Molecular pathways: targeting MALT1 paracaspase activity in lymphoma.

Fontán L, Melnick A.

Clin Cancer Res. 2013 Dec 15;19(24):6662-8. doi: 10.1158/1078-0432.CCR-12-3869. Epub 2013 Sep 4. Review.

4.

Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.

Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, Agarwal NK, Vega F.

Blood. 2013 Jun 6;121(23):4718-28. doi: 10.1182/blood-2012-12-470153. Epub 2013 Apr 30.

5.

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, Peter von Kries J, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ, Krappmann D.

Cancer Cell. 2012 Dec 11;22(6):825-37. doi: 10.1016/j.ccr.2012.11.002.

6.

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

Kloo B, Nagel D, Pfeifer M, Grau M, Düwel M, Vincendeau M, Dörken B, Lenz P, Lenz G, Krappmann D.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):272-7. doi: 10.1073/pnas.1008969108. Epub 2010 Dec 20.

7.

Lenalidomide efficacy in activated B-cell-like subtype diffuse large B-cell lymphoma is dependent upon IRF4 and cereblon expression.

Zhang LH, Kosek J, Wang M, Heise C, Schafer PH, Chopra R.

Br J Haematol. 2013 Feb;160(4):487-502. doi: 10.1111/bjh.12172. Epub 2012 Dec 18.

PMID:
23252516
8.

Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.

Bidère N, Ngo VN, Lee J, Collins C, Zheng L, Wan F, Davis RE, Lenz G, Anderson DE, Arnoult D, Vazquez A, Sakai K, Zhang J, Meng Z, Veenstra TD, Staudt LM, Lenardo MJ.

Nature. 2009 Mar 5;458(7234):92-6. doi: 10.1038/nature07613. Epub 2008 Dec 31.

9.

The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.

Pelzer C, Cabalzar K, Wolf A, Gonzalez M, Lenz G, Thome M.

Nat Immunol. 2013 Apr;14(4):337-45. doi: 10.1038/ni.2540. Epub 2013 Feb 17.

PMID:
23416615
10.

MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression.

Afonina IS, Elton L, Carpentier I, Beyaert R.

FEBS J. 2015 Sep;282(17):3286-97. doi: 10.1111/febs.13325. Epub 2015 Jun 10. Review.

PMID:
25996250
11.

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.

Naylor TL, Tang H, Ratsch BA, Enns A, Loo A, Chen L, Lenz P, Waters NJ, Schuler W, Dörken B, Yao YM, Warmuth M, Lenz G, Stegmeier F.

Cancer Res. 2011 Apr 1;71(7):2643-53. doi: 10.1158/0008-5472.CAN-10-2525. Epub 2011 Feb 15.

12.

MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A.

Cancer Cell. 2012 Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003.

13.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D.

Chem Biol. 2015 Jan 22;22(1):129-38. doi: 10.1016/j.chembiol.2014.10.021. Epub 2014 Dec 31.

15.

Attacking MALT1 for ABC-DLBCL therapy.

Krappmann D.

Oncotarget. 2012 Dec;3(12):1489-90. No abstract available.

16.

Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.

Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB.

J Biol Chem. 2012 Jun 8;287(24):20081-7. doi: 10.1074/jbc.M111.335463. Epub 2012 Apr 23.

17.

A loss-of-function RNA interference screen for molecular targets in cancer.

Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G, Lam LT, Dave S, Yang L, Powell J, Staudt LM.

Nature. 2006 May 4;441(7089):106-10. Epub 2006 Mar 29.

PMID:
16572121
18.

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.

Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM.

Science. 2008 Mar 21;319(5870):1676-9. doi: 10.1126/science.1153629. Epub 2008 Mar 6.

19.

Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.

Pérez de Diego R, Sánchez-Ramón S, López-Collazo E, Martínez-Barricarte R, Cubillos-Zapata C, Ferreira Cerdán A, Casanova JL, Puel A.

J Allergy Clin Immunol. 2015 Nov;136(5):1139-49. doi: 10.1016/j.jaci.2015.06.031. Epub 2015 Aug 12. Review.

PMID:
26277595
20.

Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20798-803. doi: 10.1073/pnas.0806491106. Epub 2008 Dec 22.

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