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Results: 1 to 20 of 102

1.

Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer.

Huang CH, Gabelli SB, Oldfield E, Amzel LM.

Proteins. 2010 Mar;78(4):888-99. doi: 10.1002/prot.22614.

PMID:
19876942
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. Epub 2006 May 9.

PMID:
16684881
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design.

Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM.

Proteins. 2006 Jan 1;62(1):80-8.

PMID:
16288456
[PubMed - indexed for MEDLINE]
4.

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM.

BMC Struct Biol. 2012 Dec 12;12:32. doi: 10.1186/1472-6807-12-32.

PMID:
23234314
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.

Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):802-10. doi: 10.1107/S1399004713033221. Epub 2014 Feb 22.

PMID:
24598749
[PubMed - indexed for MEDLINE]
6.

Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.

Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM.

J Med Chem. 2012 Jul 26;55(14):6445-54. doi: 10.1021/jm300425y. Epub 2012 Jul 5.

PMID:
22715997
[PubMed - indexed for MEDLINE]
7.

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.

Liu YL, Lindert S, Zhu W, Wang K, McCammon JA, Oldfield E.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2530-9. doi: 10.1073/pnas.1409061111. Epub 2014 Jun 9.

PMID:
24927548
[PubMed - indexed for MEDLINE]
8.

Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.

Montalvetti A, Bailey BN, Martin MB, Severin GW, Oldfield E, Docampo R.

J Biol Chem. 2001 Sep 7;276(36):33930-7. Epub 2001 Jul 2.

PMID:
11435429
[PubMed - indexed for MEDLINE]
Free Article
9.

Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

Rosso VS, Szajnman SH, Malayil L, Galizzi M, Moreno SN, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2011 Apr 1;19(7):2211-7. doi: 10.1016/j.bmc.2011.02.037.

PMID:
21419634
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.

Ferrer-Casal M, Li C, Galizzi M, Stortz CA, Szajnman SH, Docampo R, Moreno SN, Rodriguez JB.

Bioorg Med Chem. 2014 Jan 1;22(1):398-405. doi: 10.1016/j.bmc.2013.11.010. Epub 2013 Nov 13.

PMID:
24300918
[PubMed - indexed for MEDLINE]
11.

Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase.

Ohno K, Mori K, Orita M, Takeuchi M.

Curr Med Chem. 2011;18(2):220-33. Review.

PMID:
21110804
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.

Rodrígues-Poveda CA, González-Pacanowska D, Szajnman SH, Rodríguez JB.

Antimicrob Agents Chemother. 2012 Aug;56(8):4483-6. doi: 10.1128/AAC.00796-12. Epub 2012 May 14.

PMID:
22585217
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Bisphosphonate metal complexes as selective inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.

Demoro B, Caruso F, Rossi M, Benítez D, González M, Cerecetto H, Galizzi M, Malayil L, Docampo R, Faccio R, Mombrú AW, Gambino D, Otero L.

Dalton Trans. 2012 Jun 7;41(21):6468-76. doi: 10.1039/c2dt12179d. Epub 2012 Feb 17.

PMID:
22344249
[PubMed - indexed for MEDLINE]
14.

Bisphosphonates: the first 40 years.

Russell RG.

Bone. 2011 Jul;49(1):2-19. doi: 10.1016/j.bone.2011.04.022. Epub 2011 May 1. Review.

PMID:
21555003
[PubMed - indexed for MEDLINE]
15.

Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase.

Kawasaki Y, Sekiguchi M, Kawasaki M, Hirakura Y.

Chem Pharm Bull (Tokyo). 2014;62(1):77-83. Epub 2013 Oct 29.

PMID:
24172032
[PubMed - indexed for MEDLINE]
Free Article
16.

Synthesis and evaluation of chlorinated substrate analogues for farnesyl diphosphate synthase.

Heaps NA, Poulter CD.

J Org Chem. 2011 Mar 18;76(6):1838-43. doi: 10.1021/jo1024305. Epub 2011 Feb 24.

PMID:
21344952
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase.

Stresing V, Fournier PG, Bellahcène A, Benzaïd I, Mönkkönen H, Colombel M, Ebetino FH, Castronovo V, Clézardin P.

Bone. 2011 Feb;48(2):259-66. doi: 10.1016/j.bone.2010.09.035. Epub 2010 Oct 20.

PMID:
20920623
[PubMed - indexed for MEDLINE]
18.

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.

Yin F, Cao R, Goddard A, Zhang Y, Oldfield E.

J Am Chem Soc. 2006 Mar 22;128(11):3524-5.

PMID:
16536518
[PubMed - indexed for MEDLINE]
19.

Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

Szajnman SH, García Liñares GE, Li ZH, Jiang C, Galizzi M, Bontempi EJ, Ferella M, Moreno SN, Docampo R, Rodriguez JB.

Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. Epub 2007 Dec 10.

PMID:
18096393
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics.

Sigman L, Sánchez VM, Turjanski AG.

J Mol Graph Model. 2006 Nov;25(3):345-52. Epub 2006 Mar 15.

PMID:
16540358
[PubMed - indexed for MEDLINE]
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