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Results: 1 to 20 of 243

Similar articles for PubMed (Select 19854650)

1.

Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.

Trova MP, Barnes KD, Alicea L, Benanti T, Bielaska M, Bilotta J, Bliss B, Duong TN, Haydar S, Herr RJ, Hui Y, Johnson M, Lehman JM, Peace D, Rainka M, Snider P, Salamone S, Tregay S, Zheng X, Friedrich TD.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6613-7. doi: 10.1016/j.bmcl.2009.10.011. Epub 2009 Oct 12.

PMID:
19854650
2.

Purine Analogues as Kinase Inhibitors: A Review.

Sharma S, Mehndiratta S, Yadav S, Singh M, Bedi PM, Nepali K.

Recent Pat Anticancer Drug Discov. 2015 Jun 17. [Epub ahead of print]

PMID:
26081925
3.

Evaluation of WO2014075392 and WO2014075393, Merck's first PI3Kδ inhibitor filings.

Norman P.

Expert Opin Ther Pat. 2014 Nov;24(11):1277-82. doi: 10.1517/13543776.2014.969710. Review.

PMID:
25326077
4.

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.

Houzé S, Hoang NT, Lozach O, Le Bras J, Meijer L, Galons H, Demange L.

Molecules. 2014 Sep 23;19(9):15237-57. doi: 10.3390/molecules190915237.

5.

Current compound coverage of the kinome.

Hu Y, Furtmann N, Bajorath J.

J Med Chem. 2015 Jan 8;58(1):30-40. doi: 10.1021/jm5008159. Epub 2014 Jul 30.

PMID:
25051177
6.

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells.

Defaux J, Antoine M, Logé C, Le Borgne M, Schuster T, Seipelt I, Aicher B, Teifel M, Günther E, Gerlach M, Marchand P.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3748-52. doi: 10.1016/j.bmcl.2014.06.078. Epub 2014 Jul 3.

PMID:
25022204
7.

Halogenated diarylacetylenes repress c-myc expression in cancer cells.

Sviripa VM, Zhang W, Kril LM, Liu AX, Yuan Y, Zhan CG, Liu C, Watt DS.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3638-40. doi: 10.1016/j.bmcl.2014.04.113. Epub 2014 May 9.

PMID:
24930834
8.

Guanidinium-based derivatives: searching for new kinase inhibitors.

Diez-Cecilia E, Kelly B, Perez C, Zisterer DM, Nevin DK, Lloyd DG, Rozas I.

Eur J Med Chem. 2014 Jun 23;81:427-41. doi: 10.1016/j.ejmech.2014.05.025. Epub 2014 May 9.

PMID:
24858546
9.

Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity.

Duan YT, Yao YF, Huang W, Makawana JA, Teraiya SB, Thumar NJ, Tang DJ, Tao XX, Wang ZC, Jiang AQ, Zhu HL.

Bioorg Med Chem. 2014 Jun 1;22(11):2947-54. doi: 10.1016/j.bmc.2014.04.005. Epub 2014 Apr 13.

PMID:
24792811
10.

Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives.

More KN, Jang HW, Hong VS, Lee J.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2424-8. doi: 10.1016/j.bmcl.2014.04.035. Epub 2014 Apr 16.

PMID:
24775304
11.

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.

Diab S, Teo T, Kumarasiri M, Li P, Yu M, Lam F, Basnet SK, Sykes MJ, Albrecht H, Milne R, Wang S.

ChemMedChem. 2014 May;9(5):962-72. doi: 10.1002/cmdc.201300552. Epub 2014 Feb 12.

PMID:
24677692
12.

New frontiers in kinases: second generation inhibitors.

Laufer S, Bajorath J.

J Med Chem. 2014 Mar 27;57(6):2167-8. doi: 10.1021/jm500195x. Epub 2014 Mar 7. No abstract available.

PMID:
24606189
13.

Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.

Morales F, Ramírez A, Conejo-García A, Morata C, Marchal JA, Campos JM.

Eur J Med Chem. 2014 Apr 9;76:118-24. doi: 10.1016/j.ejmech.2014.02.012. Epub 2014 Feb 10.

PMID:
24583351
14.

Discovery of N-(3-((7H-purin-6-yl)thio)-4-hydroxynaphthalen-1-yl)-sulfonamide derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part III.

Xu F, Xu H, Wang X, Zhang L, Wen Q, Zhang Y, Xu W.

Bioorg Med Chem. 2014 Feb 15;22(4):1487-95. doi: 10.1016/j.bmc.2013.11.052. Epub 2013 Dec 8.

PMID:
24440479
15.

Synthesis and anticancer activity of novel C6-piperazine substituted purine steroid-nucleosides analogues.

Huang LH, Xu HD, Yang ZY, Zheng YF, Liu HM.

Steroids. 2014 Apr;82:1-6. doi: 10.1016/j.steroids.2013.12.004. Epub 2013 Dec 28.

PMID:
24378780
16.

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro.

Cihalova D, Hofman J, Ceckova M, Staud F.

PLoS One. 2013 Dec 23;8(12):e83467. doi: 10.1371/journal.pone.0083467. eCollection 2013.

17.

Synthesis, biological evaluation and SAR of 3-benzoates of ingenol for treatment of actinic keratosis and non-melanoma skin cancer.

Grue-Sørensen G, Liang X, Månsson K, Vedsø P, Dahl Sørensen M, Soor A, Stahlhut M, Bertelsen M, Engell KM, Högberg T.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):54-60. doi: 10.1016/j.bmcl.2013.11.073. Epub 2013 Dec 4.

PMID:
24332494
18.

Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents.

Shao H, Shi S, Foley DW, Lam F, Abbas AY, Liu X, Huang S, Jiang X, Baharin N, Fischer PM, Wang S.

Eur J Med Chem. 2013;70:447-55. doi: 10.1016/j.ejmech.2013.08.052. Epub 2013 Sep 15.

PMID:
24185375
19.

Novel Mps1 kinase inhibitors: from purine to pyrrolopyrimidine and quinazoline leads.

Bursavich MG, Dastrup D, Shenderovich M, Yager KM, Cimbora DM, Williams B, Kumar DV.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6829-33. doi: 10.1016/j.bmcl.2013.10.008. Epub 2013 Oct 11.

PMID:
24183538
20.

New diarylamides and diarylureas possessing 8-amino(acetamido)quinoline scaffold: synthesis, antiproliferative activities against melanoma cell lines, kinase inhibition, and in silico studies.

Koh EJ, El-Gamal MI, Oh CH, Lee SH, Sim T, Kim G, Choi HS, Hong JH, Lee SG, Yoo KH.

Eur J Med Chem. 2013;70:10-21. doi: 10.1016/j.ejmech.2013.06.060. Epub 2013 Aug 9.

PMID:
24128410
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