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Results: 1 to 20 of 764

1.

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding.

Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israël A, Véron M, Agou F.

J Mol Biol. 2010 Jan 8;395(1):89-104. doi: 10.1016/j.jmb.2009.10.018. Epub 2009 Oct 23.

PMID:
19854204
[PubMed - indexed for MEDLINE]
2.

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin.

Yoshikawa A, Sato Y, Yamashita M, Mimura H, Yamagata A, Fukai S.

FEBS Lett. 2009 Oct 20;583(20):3317-22. doi: 10.1016/j.febslet.2009.09.028. Epub 2009 Sep 18.

PMID:
19766637
[PubMed - indexed for MEDLINE]
Free Article
3.

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO.

Wyler E, Kaminska M, Coïc YM, Baleux F, Véron M, Agou F.

Protein Sci. 2007 Sep;16(9):2013-22.

PMID:
17766391
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome.

Ngadjeua F, Chiaravalli J, Traincard F, Raynal B, Fontan E, Agou F.

J Biol Chem. 2013 Nov 22;288(47):33722-37. doi: 10.1074/jbc.M113.483305. Epub 2013 Oct 7.

PMID:
24100029
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO.

Chiaravalli J, Fontan E, Fsihi H, Coic YM, Baleux F, Véron M, Agou F.

Biochem Pharmacol. 2011 Nov 1;82(9):1163-74. doi: 10.1016/j.bcp.2011.07.083. Epub 2011 Jul 23.

PMID:
21803029
[PubMed - indexed for MEDLINE]
6.

Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.

Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB.

J Biol Chem. 2008 Jan 4;283(1):76-86. Epub 2007 Oct 31.

PMID:
17977820
[PubMed - indexed for MEDLINE]
Free Article
7.

A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.

Vinolo E, Sebban H, Chaffotte A, Israël A, Courtois G, Véron M, Agou F.

J Biol Chem. 2006 Mar 10;281(10):6334-48. Epub 2005 Dec 26.

PMID:
16379012
[PubMed - indexed for MEDLINE]
Free Article
8.

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains.

Agou F, Traincard F, Vinolo E, Courtois G, Yamaoka S, Israël A, Véron M.

J Biol Chem. 2004 Jul 2;279(27):27861-9. Epub 2004 Apr 23.

PMID:
15107419
[PubMed - indexed for MEDLINE]
Free Article
9.

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein.

Hubeau M, Ngadjeua F, Puel A, Israel L, Feinberg J, Chrabieh M, Belani K, Bodemer C, Fabre I, Plebani A, Boisson-Dupuis S, Picard C, Fischer A, Israel A, Abel L, Veron M, Casanova JL, Agou F, Bustamante J.

Blood. 2011 Jul 28;118(4):926-35. doi: 10.1182/blood-2010-10-315234. Epub 2011 May 26.

PMID:
21622647
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.

Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, Véron M, Agou F, Israël A.

EMBO J. 2009 Oct 7;28(19):2885-95. doi: 10.1038/emboj.2009.241. Epub 2009 Sep 17.

PMID:
19763089
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex.

Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K.

Mol Cell Biol. 2014 Apr;34(7):1322-35. doi: 10.1128/MCB.01538-13. Epub 2014 Jan 27.

PMID:
24469399
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation.

Cordier F, Vinolo E, Véron M, Delepierre M, Agou F.

J Mol Biol. 2008 Apr 11;377(5):1419-32. doi: 10.1016/j.jmb.2008.01.048. Epub 2008 Jan 30.

PMID:
18313693
[PubMed - indexed for MEDLINE]
13.

Identification of a new NEMO/TRAF6 interface affected in incontinentia pigmenti pathology.

Gautheron J, Pescatore A, Fusco F, Esposito E, Yamaoka S, Agou F, Ursini MV, Courtois G.

Hum Mol Genet. 2010 Aug 15;19(16):3138-49. doi: 10.1093/hmg/ddq222. Epub 2010 Jun 7.

PMID:
20529958
[PubMed - indexed for MEDLINE]
Free Article
14.

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.

Nat Cell Biol. 2009 Feb;11(2):123-32. doi: 10.1038/ncb1821. Epub 2009 Jan 11.

PMID:
19136968
[PubMed - indexed for MEDLINE]
15.

NEMO oligomerization and its ubiquitin-binding properties.

Ivins FJ, Montgomery MG, Smith SJ, Morris-Davies AC, Taylor IA, Rittinger K.

Biochem J. 2009 Jun 26;421(2):243-51. doi: 10.1042/BJ20090427.

PMID:
19422324
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.

Bosanac I, Wertz IE, Pan B, Yu C, Kusam S, Lam C, Phu L, Phung Q, Maurer B, Arnott D, Kirkpatrick DS, Dixit VM, Hymowitz SG.

Mol Cell. 2010 Nov 24;40(4):548-57. doi: 10.1016/j.molcel.2010.10.009.

PMID:
21095585
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.

Agou F, Courtois G, Chiaravalli J, Baleux F, Coïc YM, Traincard F, Israël A, Véron M.

J Biol Chem. 2004 Dec 24;279(52):54248-57. Epub 2004 Oct 5.

PMID:
15466857
[PubMed - indexed for MEDLINE]
Free Article
18.

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Cote SM, Gilmore TD, Shaffer R, Weber U, Bollam R, Golden MS, Glover K, Herscovitch M, Ennis T, Allen KN, Whitty A.

Biochemistry. 2013 Dec 23;52(51):9141-54. doi: 10.1021/bi401368r. Epub 2013 Dec 10.

PMID:
24266532
[PubMed - indexed for MEDLINE]
19.

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.

Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ.

Mol Cell. 2006 Apr 21;22(2):245-57. Epub 2006 Apr 6.

PMID:
16603398
[PubMed - indexed for MEDLINE]
Free Article
20.

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha.

Tang ED, Wang CY, Xiong Y, Guan KL.

J Biol Chem. 2003 Sep 26;278(39):37297-305. Epub 2003 Jul 16.

PMID:
12867425
[PubMed - indexed for MEDLINE]
Free Article
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