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Items: 1 to 20 of 114

1.

Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.

Kundu S, Brinkmeyer MK, Livingston AL, David SS.

DNA Repair (Amst). 2009 Dec 3;8(12):1400-10. doi: 10.1016/j.dnarep.2009.09.009.

3.

Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY.

Livingston AL, Kundu S, Henderson Pozzi M, Anderson DW, David SS.

Biochemistry. 2005 Nov 1;44(43):14179-90.

PMID:
16245934
4.

Functional analysis of MUTYH mutated proteins associated with familial adenomatous polyposis.

D'Agostino VG, Minoprio A, Torreri P, Marinoni I, Bossa C, Petrucci TC, Albertini AM, Ranzani GN, Bignami M, Mazzei F.

DNA Repair (Amst). 2010 Jun 4;9(6):700-7. doi: 10.1016/j.dnarep.2010.03.008. Epub 2010 Apr 24.

PMID:
20418187
5.

Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.

Carcinogenesis. 2012 Nov;33(11):2301-9. doi: 10.1093/carcin/bgs270. Epub 2012 Aug 26.

6.

Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.

Brinkmeyer MK, David SS.

DNA Repair (Amst). 2015 Oct;34:39-51. doi: 10.1016/j.dnarep.2015.08.001. Epub 2015 Aug 12.

PMID:
26377631
8.

Characterization of mutant MUTYH proteins associated with familial colorectal cancer.

Ali M, Kim H, Cleary S, Cupples C, Gallinger S, Bristow R.

Gastroenterology. 2008 Aug;135(2):499-507. doi: 10.1053/j.gastro.2008.04.035. Epub 2008 May 7.

9.

Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain.

Chmiel NH, Golinelli MP, Francis AW, David SS.

Nucleic Acids Res. 2001 Jan 15;29(2):553-64.

10.

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.

Parker AR, Sieber OM, Shi C, Hua L, Takao M, Tomlinson IP, Eshleman JR.

Carcinogenesis. 2005 Nov;26(11):2010-8. Epub 2005 Jun 29.

11.

Role of MUTYH in human cancer.

Mazzei F, Viel A, Bignami M.

Mutat Res. 2013 Mar-Apr;743-744:33-43. doi: 10.1016/j.mrfmmm.2013.03.003. Epub 2013 Mar 16. Review.

PMID:
23507534
12.

MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay.

Molatore S, Russo MT, D'Agostino VG, Barone F, Matsumoto Y, Albertini AM, Minoprio A, Degan P, Mazzei F, Bignami M, Ranzani GN.

Hum Mutat. 2010 Feb;31(2):159-66. doi: 10.1002/humu.21158.

PMID:
19953527
13.

Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability.

Ruggieri V, Pin E, Russo MT, Barone F, Degan P, Sanchez M, Quaia M, Minoprio A, Turco E, Mazzei F, Viel A, Bignami M.

Oncogene. 2013 Sep 19;32(38):4500-8. doi: 10.1038/onc.2012.479. Epub 2012 Oct 29.

PMID:
23108399
14.

Functional Complementation Assay for 47 MUTYH Variants in a MutY-Disrupted Escherichia coli Strain.

Komine K, Shimodaira H, Takao M, Soeda H, Zhang X, Takahashi M, Ishioka C.

Hum Mutat. 2015 Jul;36(7):704-11. doi: 10.1002/humu.22794.

15.

Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays.

Brinkmeyer MK, Pope MA, David SS.

Chem Biol. 2012 Feb 24;19(2):276-86. doi: 10.1016/j.chembiol.2011.11.011.

16.

Mutator phenotype of MUTYH-null mouse embryonic stem cells.

Hirano S, Tominaga Y, Ichinoe A, Ushijima Y, Tsuchimoto D, Honda-Ohnishi Y, Ohtsubo T, Sakumi K, Nakabeppu Y.

J Biol Chem. 2003 Oct 3;278(40):38121-4. Epub 2003 Aug 13.

17.

DNA damage recognition and repair by the murine MutY homologue.

Pope MA, David SS.

DNA Repair (Amst). 2005 Jan 2;4(1):91-102.

PMID:
15533841
18.

MutYH (MYH) and colorectal cancer.

Sampson JR, Jones S, Dolwani S, Cheadle JP.

Biochem Soc Trans. 2005 Aug;33(Pt 4):679-83. Review.

PMID:
16042573
19.

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases.

Woods RD, O'Shea VL, Chu A, Cao S, Richards JL, Horvath MP, David SS.

Nucleic Acids Res. 2016 Jan 29;44(2):801-10. doi: 10.1093/nar/gkv1469. Epub 2015 Dec 15.

20.

Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition.

Kundu S, Brinkmeyer MK, Eigenheer RA, David SS.

DNA Repair (Amst). 2010 Oct 5;9(10):1026-37. doi: 10.1016/j.dnarep.2010.07.002. Epub 2010 Aug 17.

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