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Items: 1 to 20 of 102

1.

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC.

Mol Cell. 2009 Oct 9;36(1):131-40. doi: 10.1016/j.molcel.2009.07.025.

2.

Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.

Thu KL, Pikor LA, Chari R, Wilson IM, Macaulay CE, English JC, Tsao MS, Gazdar AF, Lam S, Lam WL, Lockwood WW.

J Thorac Oncol. 2011 Sep;6(9):1521-9. doi: 10.1097/JTO.0b013e3182289479.

3.

Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

Edwards MR, Basler CF.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S154-9. doi: 10.1093/infdis/jiv050. Epub 2015 Apr 29.

PMID:
25926686
4.

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation.

Kim JE, You DJ, Lee C, Ahn C, Seong JY, Hwang JI.

Cell Signal. 2010 Nov;22(11):1645-54. doi: 10.1016/j.cellsig.2010.06.004. Epub 2010 Jun 20.

PMID:
20600852
5.

Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.

Awuh JA, Haug M, Mildenberger J, Marstad A, Do CP, Louet C, Stenvik J, Steigedal M, Damås JK, Halaas Ø, Flo TH.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4272-80. doi: 10.1073/pnas.1423449112. Epub 2015 Jul 20.

6.

Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages.

Lv P, Xue P, Dong J, Peng H, Clewell R, Wang A, Wang Y, Peng S, Qu W, Zhang Q, Andersen ME, Pi J.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):697-702. doi: 10.1016/j.taap.2013.07.012. Epub 2013 Jul 29.

PMID:
23906629
7.

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.

Jiang ZY, Chu HX, Xi MY, Yang TT, Jia JM, Huang JJ, Guo XK, Zhang XJ, You QD, Sun HP.

PLoS One. 2013 Sep 16;8(9):e75076. doi: 10.1371/journal.pone.0075076. eCollection 2013.

9.

EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z.

Mol Cell. 2012 Dec 14;48(5):771-84. doi: 10.1016/j.molcel.2012.09.028. Epub 2012 Nov 1.

10.

IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells.

Bai L, Chen W, Chen W, Wang X, Tang H, Lin Y.

Mol Cancer Ther. 2009 Jun;8(6):1636-45. doi: 10.1158/1535-7163.MCT-09-0068. Epub 2009 Jun 9.

11.

Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.

Tsuchiya Y, Asano T, Nakayama K, Kato T Jr, Karin M, Kamata H.

Mol Cell. 2010 Aug 27;39(4):570-82. doi: 10.1016/j.molcel.2010.07.030.

12.

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

Adli M, Merkhofer E, Cogswell P, Baldwin AS.

PLoS One. 2010 Feb 25;5(2):e9428. doi: 10.1371/journal.pone.0009428.

13.

Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.

Li SZ, Zhang HH, Liang JB, Song Y, Jin BX, Xing NN, Fan GC, Du RL, Zhang XD.

Biochim Biophys Acta. 2014 Jul;1843(7):1365-72. doi: 10.1016/j.bbamcr.2014.03.028. Epub 2014 Apr 12.

14.

NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.

Solt LA, Madge LA, May MJ.

J Biol Chem. 2009 Oct 2;284(40):27596-608. doi: 10.1074/jbc.M109.047563. Epub 2009 Aug 7.

15.

Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.

Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H.

J Immunol. 2011 Sep 1;187(5):2202-12. doi: 10.4049/jimmunol.1100285. Epub 2011 Aug 1.

16.

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.

Solt LA, Madge LA, Orange JS, May MJ.

J Biol Chem. 2007 Mar 23;282(12):8724-33. Epub 2007 Jan 23.

17.

Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.

Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.

Biomed Res Int. 2014;2014:159459. doi: 10.1155/2014/159459. Epub 2014 Jul 9.

18.

[Regulatory effects of lanthanum chloride on the activation of nuclear factor kappa B inhibitor kinase beta induced by tumor necrosis factor alpha].

Guo F, He F, Xiu M, Lou YL, Xie A, Liu F, Li GH.

Zhonghua Shao Shang Za Zhi. 2013 Dec;29(6):531-6. Chinese.

PMID:
24495640
19.

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V.

Mol Cell. 2010 Oct 8;40(1):75-86. doi: 10.1016/j.molcel.2010.09.010.

20.

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.

Baird L, Dinkova-Kostova AT.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):58-65. doi: 10.1016/j.bbrc.2013.02.065. Epub 2013 Feb 26.

PMID:
23454126
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