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Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.

Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM.

J Allergy Clin Immunol. 2010 Jan;125(1):160-9.e1-5. doi: 10.1016/j.jaci.2009.06.049. Epub 2009 Oct 8.


Topical application of PPARα (but not β/δ or γ) suppresses atopic dermatitis in NC/Nga mice.

Chiba T, Takeuchi S, Esaki H, Yamamura K, Kurihara Y, Moroi Y, Furue M.

Allergy. 2012 Jul;67(7):936-42. doi: 10.1111/j.1398-9995.2012.02844.x. Epub 2012 May 15.


Efficacy of combined peroxisome proliferator-activated receptor-α ligand and glucocorticoid therapy in a murine model of atopic dermatitis.

Hatano Y, Elias PM, Crumrine D, Feingold KR, Katagiri K, Fujiwara S.

J Invest Dermatol. 2011 Sep;131(9):1845-52. doi: 10.1038/jid.2011.144. Epub 2011 Jun 2.


Panduratin A, an activator of PPAR-α/δ, suppresses the development of oxazolone-induced atopic dermatitis-like symptoms in hairless mice.

Kim MS, Pyun HB, Hwang JK.

Life Sci. 2014 Mar 28;100(1):45-54. doi: 10.1016/j.lfs.2014.01.076. Epub 2014 Feb 11.


Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.

Demerjian M, Choi EH, Man MQ, Chang S, Elias PM, Feingold KR.

Exp Dermatol. 2009 Jul;18(7):643-9. doi: 10.1111/j.1600-0625.2009.00841.x. Epub 2009 Feb 19.


Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.

Staumont-Sallé D, Abboud G, Brénuchon C, Kanda A, Roumier T, Lavogiez C, Fleury S, Rémy P, Papin JP, Bertrand-Michel J, Tercé F, Staels B, Delaporte E, Capron M, Dombrowicz D.

J Allergy Clin Immunol. 2008 Apr;121(4):962-8.e6. doi: 10.1016/j.jaci.2007.12.1165. Epub 2008 Feb 4.


Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.

Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM.

J Invest Dermatol. 2008 Jan;128(1):79-86. Epub 2007 Aug 2.


Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM.

J Invest Dermatol. 2009 Jul;129(7):1824-35. doi: 10.1038/jid.2008.444. Epub 2009 Jan 29.


PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis.

Jiang YJ, Kim P, Lu YF, Feingold KR.

Exp Dermatol. 2011 Jul;20(7):595-9. doi: 10.1111/j.1600-0625.2011.01269.x. Epub 2011 Apr 4.


Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation.

Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE, Moser AH, Michalik L, Desvergne B, Wahli W, Li M, Metzger D, Chambon PH, Elias PM, Feingold KR.

J Invest Dermatol. 2004 Aug;123(2):305-12.


Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model.

Yoon NY, Jung My, Kim DH, Lee HJ, Choi EH.

Arch Dermatol Res. 2015 Sep;307(7):569-81. doi: 10.1007/s00403-015-1558-y. Epub 2015 Mar 19.


Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism.

Moulin D, Bianchi A, Boyault S, Sebillaud S, Koufany M, Francois M, Netter P, Jouzeau JY, Terlain B.

Arthritis Rheum. 2005 Mar;52(3):759-69.


Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.

Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J, Fluhr JW, Man MQ, Elias PM, Feingold KR.

J Invest Dermatol. 2002 Jan;118(1):94-101.


Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.

Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK.

J Clin Invest. 2004 Dec;114(11):1564-76.

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