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Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.

Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J.

J Biol Chem. 2009 Dec 11;284(50):34889-900. doi: 10.1074/jbc.M109.044875. Epub 2009 Oct 8.


Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation.

Leichner GS, Avner R, Harats D, Roitelman J.

Mol Biol Cell. 2009 Jul;20(14):3330-41. doi: 10.1091/mbc.E08-09-0953. Epub 2009 May 20.


Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.

Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J.

J Biol Chem. 2008 Nov 28;283(48):33772-83. doi: 10.1074/jbc.M806108200. Epub 2008 Oct 3.


Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.

Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S.

J Biol Chem. 2007 Nov 23;282(47):33908-14. Epub 2007 Sep 14.


Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.

Lee JN, Song B, DeBose-Boyd RA, Ye J.

J Biol Chem. 2006 Dec 22;281(51):39308-15. Epub 2006 Oct 16.


Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo Y, Debose-Boyd RA.

Crit Rev Biochem Mol Biol. 2010 Jun;45(3):185-98. doi: 10.3109/10409238.2010.485605. Review.


Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5.


Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells.

Elsabrouty R, Jo Y, Dinh TT, DeBose-Boyd RA.

Mol Biol Cell. 2013 Nov;24(21):3300-8. doi: 10.1091/mbc.E13-03-0157. Epub 2013 Sep 11.


Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.

Lee JN, Gong Y, Zhang X, Ye J.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4958-63. Epub 2006 Mar 20.


Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.

Lee PC, Sever N, Debose-Boyd RA.

J Biol Chem. 2005 Jul 1;280(26):25242-9. Epub 2005 May 2.


Regulation of ER-associated degradation via p97/VCP-interacting motif.

Ballar P, Fang S.

Biochem Soc Trans. 2008 Oct;36(Pt 5):818-22. doi: 10.1042/BST0360818.


Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen AD, Lee SH, DeBose-Boyd RA.

J Biol Chem. 2009 Sep 25;284(39):26778-88. doi: 10.1074/jbc.M109.032342. Epub 2009 Jul 28.


Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway.

Fisher EA, Khanna NA, McLeod RS.

J Lipid Res. 2011 Jun;52(6):1170-80. doi: 10.1194/jlr.M011726. Epub 2011 Mar 18.


Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.

Lee PC, DeBose-Boyd RA.

J Lipid Res. 2010 Jan;51(1):192-201. doi: 10.1194/jlr.M900336-JLR200. Epub .


Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.

Gong Y, Lee JN, Brown MS, Goldstein JL, Ye J.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6154-9. Epub 2006 Apr 10.


Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol.

Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA.

J Biol Chem. 2003 Dec 26;278(52):52479-90. Epub 2003 Oct 16.

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