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Results: 1 to 20 of 225

1.

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8. doi: 10.1073/pnas.0908301106. Epub 2009 Sep 14.

PMID:
19805286
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target.

De Simone G, Supuran CT.

Biochim Biophys Acta. 2010 Feb;1804(2):404-9. doi: 10.1016/j.bbapap.2009.07.027. Epub 2009 Aug 11. Review.

PMID:
19679200
[PubMed - indexed for MEDLINE]
Free Article
3.

Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.

Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Jänis J, Valjakka J, Pastoreková S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S.

J Biol Chem. 2008 Oct 10;283(41):27799-809. doi: 10.1074/jbc.M800938200. Epub 2008 Aug 13.

PMID:
18703501
[PubMed - indexed for MEDLINE]
Free Article
4.

Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Genis C, Sippel KH, Case N, Cao W, Avvaru BS, Tartaglia LJ, Govindasamy L, Tu C, Agbandje-McKenna M, Silverman DN, Rosser CJ, McKenna R.

Biochemistry. 2009 Feb 17;48(6):1322-31. doi: 10.1021/bi802035f.

PMID:
19170619
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, Christianson DW.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9545-50. Epub 2001 Aug 7.

PMID:
11493685
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Targeting tumor-associated carbonic anhydrase IX in cancer therapy.

Thiry A, Dogné JM, Masereel B, Supuran CT.

Trends Pharmacol Sci. 2006 Nov;27(11):566-73. Epub 2006 Sep 25.

PMID:
16996620
[PubMed - indexed for MEDLINE]
7.

The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.

Innocenti A, Pastorekova S, Pastorek J, Scozzafava A, De Simone G, Supuran CT.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5825-8. doi: 10.1016/j.bmcl.2009.08.088. Epub 2009 Aug 31.

PMID:
19751975
[PubMed - indexed for MEDLINE]
8.

Drug design studies of the novel antitumor targets carbonic anhydrase IX and XII.

Guler OO, De Simone G, Supuran CT.

Curr Med Chem. 2010;17(15):1516-26. Review.

PMID:
20166929
[PubMed - indexed for MEDLINE]
9.

Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.

Hulikova A, Zatovicova M, Svastova E, Ditte P, Brasseur R, Kettmann R, Supuran CT, Kopacek J, Pastorek J, Pastorekova S.

FEBS Lett. 2009 Nov 19;583(22):3563-8. doi: 10.1016/j.febslet.2009.10.060. Epub 2009 Oct 25.

PMID:
19861127
[PubMed - indexed for MEDLINE]
Free Article
10.

Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.

Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW.

J Biol Chem. 2004 Feb 20;279(8):7223-8. Epub 2003 Dec 3.

PMID:
14660577
[PubMed - indexed for MEDLINE]
Free Article
11.

Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.

Winum JY, Rami M, Scozzafava A, Montero JL, Supuran C.

Med Res Rev. 2008 May;28(3):445-63. Review.

PMID:
17880011
[PubMed - indexed for MEDLINE]
12.

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

Svastová E, Hulíková A, Rafajová M, Zat'ovicová M, Gibadulinová A, Casini A, Cecchi A, Scozzafava A, Supuran CT, Pastorek J, Pastoreková S.

FEBS Lett. 2004 Nov 19;577(3):439-45.

PMID:
15556624
[PubMed - indexed for MEDLINE]
Free Article
13.

Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.

Ditte P, Dequiedt F, Svastova E, Hulikova A, Ohradanova-Repic A, Zatovicova M, Csaderova L, Kopacek J, Supuran CT, Pastorekova S, Pastorek J.

Cancer Res. 2011 Dec 15;71(24):7558-67. doi: 10.1158/0008-5472.CAN-11-2520. Epub 2011 Oct 28.

PMID:
22037869
[PubMed - indexed for MEDLINE]
Free Article
14.

Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.

Pastorekova S, Vullo D, Casini A, Scozzafava A, Pastorek J, Nishimori I, Supuran CT.

J Enzyme Inhib Med Chem. 2005 Jun;20(3):211-7.

PMID:
16119190
[PubMed - indexed for MEDLINE]
15.

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.

Pinard MA, Boone CD, Rife BD, Supuran CT, McKenna R.

Bioorg Med Chem. 2013 Nov 15;21(22):7210-5. doi: 10.1016/j.bmc.2013.08.033. Epub 2013 Aug 28.

PMID:
24090602
[PubMed - indexed for MEDLINE]
16.

Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.

Puccetti L, Fasolis G, Cecchi A, Winum JY, Gamberi A, Montero JL, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 May 2;15(9):2359-64.

PMID:
15837325
[PubMed - indexed for MEDLINE]
17.

Catalysis and inhibition of human carbonic anhydrase IV.

Baird TT Jr, Waheed A, Okuyama T, Sly WS, Fierke CA.

Biochemistry. 1997 Mar 4;36(9):2669-78.

PMID:
9054574
[PubMed - indexed for MEDLINE]
18.

Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM.

Peña KL, Castel SE, de Araujo C, Espie GS, Kimber MS.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2455-60. doi: 10.1073/pnas.0910866107. Epub 2010 Jan 25.

PMID:
20133749
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

Svastova E, Witarski W, Csaderova L, Kosik I, Skvarkova L, Hulikova A, Zatovicova M, Barathova M, Kopacek J, Pastorek J, Pastorekova S.

J Biol Chem. 2012 Jan 27;287(5):3392-402. doi: 10.1074/jbc.M111.286062. Epub 2011 Dec 14.

PMID:
22170054
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Carbonic anhydrase IX as a target for designing novel anticancer drugs.

Monti SM, Supuran CT, De Simone G.

Curr Med Chem. 2012;19(6):821-30. Review.

PMID:
22214452
[PubMed - indexed for MEDLINE]

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