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Items: 1 to 20 of 178


Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

Barrès R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR.

Cell Metab. 2009 Sep;10(3):189-98. doi: 10.1016/j.cmet.2009.07.011.


Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S.

Diabetologia. 2008 Apr;51(4):615-22. doi: 10.1007/s00125-007-0916-5. Epub 2008 Feb 13.


Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.


Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter.

Sookoian S, Rosselli MS, Gemma C, Burgueño AL, Fernández Gianotti T, Castaño GO, Pirola CJ.

Hepatology. 2010 Dec;52(6):1992-2000. doi: 10.1002/hep.23927. Epub 2010 Oct 1.


AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells.

Irrcher I, Ljubicic V, Kirwan AF, Hood DA.

PLoS One. 2008;3(10):e3614. doi: 10.1371/journal.pone.0003614. Epub 2008 Oct 31.


DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.

Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR.

Nat Genet. 2003 Jan;33(1):61-5. Epub 2002 Dec 23.


Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles.

Miura S, Kai Y, Ono M, Ezaki O.

J Biol Chem. 2003 Aug 15;278(33):31385-90. Epub 2003 May 30.


Induction of DNA methylation and gene silencing by short interfering RNAs in human cells.

Kawasaki H, Taira K.

Nature. 2004 Sep 9;431(7005):211-7. Epub 2004 Aug 15. Retraction in: Taira K. Nature. 2006 Jun 29;441(7097):1176.


Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.

Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ.

Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23.


DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis.

Foltz G, Yoon JG, Lee H, Ryken TC, Sibenaller Z, Ehrich M, Hood L, Madan A.

Oncogene. 2009 Jul 23;28(29):2667-77. doi: 10.1038/onc.2009.122. Epub 2009 May 25.


PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes.

Soyal S, Krempler F, Oberkofler H, Patsch W.

Diabetologia. 2006 Jul;49(7):1477-88. Epub 2006 May 17. Review. Erratum in: Diabetologia. 2006 Sep;49(9):2225.


Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes.

Oberkofler H, Linnemayr V, Weitgasser R, Klein K, Xie M, Iglseder B, Krempler F, Paulweber B, Patsch W.

Diabetes. 2004 May;53(5):1385-93.


TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model.

Palomer X, Alvarez-Guardia D, Rodríguez-Calvo R, Coll T, Laguna JC, Davidson MM, Chan TO, Feldman AM, Vázquez-Carrera M.

Cardiovasc Res. 2009 Mar 1;81(4):703-12. doi: 10.1093/cvr/cvn327. Epub 2008 Nov 27.

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