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Results: 1 to 20 of 101

1.

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

Zhao X, D' Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A.

Dev Cell. 2009 Aug;17(2):210-21. doi: 10.1016/j.devcel.2009.07.009.

PMID:
19686682
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.

Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A.

Nat Cell Biol. 2008 Jun;10(6):643-53. doi: 10.1038/ncb1727. Epub 2008 May 18.

PMID:
18488021
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum.

D'Arca D, Zhao X, Xu W, Ramirez-Martinez NC, Iavarone A, Lasorella A.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5875-80. doi: 10.1073/pnas.0912874107. Epub 2010 Mar 15.

PMID:
20231446
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW.

Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113.

PMID:
23699408
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.

Shimizu T, Kagawa T, Inoue T, Nonaka A, Takada S, Aburatani H, Taga T.

Mol Cell Biol. 2008 Dec;28(24):7427-41. doi: 10.1128/MCB.01962-07. Epub 2008 Oct 13.

PMID:
18852283
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.

Wey A, Knoepfler PS.

Oncotarget. 2010 Jun;1(2):120-30.

PMID:
20651942
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis.

Ossipova O, Ezan J, Sokol SY.

Dev Cell. 2009 Aug;17(2):222-33. doi: 10.1016/j.devcel.2009.06.010.

PMID:
19686683
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.

Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI.

J Biol Chem. 2011 Apr 15;286(15):13754-64. doi: 10.1074/jbc.M110.194936. Epub 2011 Feb 24.

PMID:
21349854
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate.

Snyder JL, Kearns CA, Appel B.

Neural Dev. 2012 May 3;7:15. doi: 10.1186/1749-8104-7-15.

PMID:
22554084
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis.

Chapman G, Sparrow DB, Kremmer E, Dunwoodie SL.

Hum Mol Genet. 2011 Mar 1;20(5):905-16. doi: 10.1093/hmg/ddq529. Epub 2010 Dec 7.

PMID:
21147753
[PubMed - indexed for MEDLINE]
Free Article
11.

Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination.

Okigawa S, Mizoguchi T, Okano M, Tanaka H, Isoda M, Jiang YJ, Suster M, Higashijima S, Kawakami K, Itoh M.

Dev Biol. 2014 Jul 15;391(2):196-206. doi: 10.1016/j.ydbio.2014.04.011. Epub 2014 Apr 24.

PMID:
24768892
[PubMed - indexed for MEDLINE]
12.

The F-box protein Fbw7 is required for cerebellar development.

Jandke A, Da Costa C, Sancho R, Nye E, Spencer-Dene B, Behrens A.

Dev Biol. 2011 Oct 1;358(1):201-12. doi: 10.1016/j.ydbio.2011.07.030. Epub 2011 Jul 29.

PMID:
21827743
[PubMed - indexed for MEDLINE]
Free Article
13.

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.

Hoeck JD, Jandke A, Blake SM, Nye E, Spencer-Dene B, Brandner S, Behrens A.

Nat Neurosci. 2010 Nov;13(11):1365-72. doi: 10.1038/nn.2644. Epub 2010 Oct 10.

PMID:
20935640
[PubMed - indexed for MEDLINE]
14.

Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects.

Loomes KM, Stevens SA, O'Brien ML, Gonzalez DM, Ryan MJ, Segalov M, Dormans NJ, Mimoto MS, Gibson JD, Sewell W, Schaffer AA, Nah HD, Rappaport EF, Pratt SC, Dunwoodie SL, Kusumi K.

Dev Dyn. 2007 Oct;236(10):2943-51. Erratum in: Dev Dyn. 2008 Jun;237(6):1754.

PMID:
17849441
[PubMed - indexed for MEDLINE]
Free Article
15.

The MULE/HUWE1 E3 ubiquitin ligase is a tumor suppressor.

[No authors listed]

Cancer Discov. 2013 Jul;3(7):OF32. doi: 10.1158/2159-8290.CD-RW2013-119. Epub 2013 Jun 6.

PMID:
23847377
[PubMed - indexed for MEDLINE]
16.

Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.

Nagao M, Campbell K, Burns K, Kuan CY, Trumpp A, Nakafuku M.

J Cell Biol. 2008 Dec 29;183(7):1243-57. doi: 10.1083/jcb.200807130.

PMID:
19114593
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.

Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R.

J Neurosci Res. 2009 Dec;87(16):3521-34. doi: 10.1002/jnr.22169.

PMID:
19598246
[PubMed - indexed for MEDLINE]
18.

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA.

Mol Cell Biol. 2006 Nov;26(21):8022-31. Epub 2006 Sep 5.

PMID:
16954387
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim HS, Woolard K, Lai C, Bauer PO, Maric D, Song H, Li A, Kotliarova S, Zhang W, Fine HA.

Cancer Res. 2012 Nov 15;72(22):6065-75. doi: 10.1158/0008-5472.CAN-12-2594. Epub 2012 Sep 17.

PMID:
22986743
[PubMed - indexed for MEDLINE]
Free Article
20.

Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.

García-Domínguez DJ, Morello D, Cisneros E, Kontoyiannis DL, Frade JM.

Mol Biol Cell. 2011 Apr 15;22(8):1227-39. doi: 10.1091/mbc.E10-10-0808. Epub 2011 Feb 23.

PMID:
21346194
[PubMed - indexed for MEDLINE]
Free PMC Article

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